Protein Alignment Dad and Smad9

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: XP_036019060.1
• Gene: Smad9 / 55994
• MGIID: 1859993
• Length: 456
• Species: Mus musculus
• Alignment Length: 431
• Identity: 109/431 - (25%)
• Similarity: 173/431 - (40%)
• Gaps: 115/431 - (26%)

  Fly   222 EALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWE------ 280
            ::|:|:||:|                 |...|.:|...:......:|:.||.......:
Mouse    65 DSLVKKLKKK-----------------KGAMDELERALSCPGQPSKCVTIPRSLDGRLQVSHRKG 112

  Fly   281 -PHVTASRLFFWRELWNAKELKRLPTC--PAARDCIYMCCNPLHWFRILHQPETESPT-PPY--- 338
             |||...|::.|.:|.:..|||.|..|  |.......:|.||.|:.|:      |:|. ||.
Mouse   113 LPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRV------ETPVLPPVLVP 171

  Fly   339 -------QRSKMLRLKDADFEED-------SQNDAKSAAL------------------------- 364
                   |.|.:.:.:.|....:       :..|:...:|
Mouse   172 RHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQSLCPAPPSSPGHVFPQSPCPTSYPHSP 236

  Fly   365 -STWSAESTSISNIYKPALYESVTTDGKDHNINSQVWCQIAYWEMAHRVGEFFHAKTNAVNI--Y 426
             |...::|....:.::|..||           ..|.||.:||:|:.:||||.|.|.:.:|.|  :
Mouse   237 GSPSESDSPYQHSDFRPVCYE-----------EPQHWCSVAYYELNNRVGETFQASSRSVLIDGF 290

  Fly   427 TDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDSPTL 491
            ||  .::..:..||..|:....  :|.:...|..:|.||.|....|:|:.....:::|||.
Mouse   291 TD--PSNNRNRFCLGLLSNVNR--NSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQ---- 347

  Fly   492 SENLD--------RVCKVMPGYCLKAFETNR-AELLSMRDHGHHPMGPV----DYFSIKISFGKG 543
            |.|.:        .|||:..|..||.|.... |:||:  ...||....|    ...:|::||.||
Mouse   348 SRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLA--QSVHHGFEVVYELTKMCTIRMSFVKG 410

  Fly   544 WGRDYKRQDIMGCPCWLEVHFSHLRXQYL--MLARSAGPHS 582
            ||.:|.|||:...|||:|:|. |.. |:|  :|.:...||:
Mouse   411 WGAEYHRQDVTSTPCWIEIHL-HGPLQWLDKVLTQMGSPHN 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	28/115 (24%)
		MH2_I-SMAD	400..565	CDD:199821	60/179 (34%)
Smad9	XP_036019060.1	MH1_SMAD_1_5_9	41..162	CDD:199814	28/119 (24%)
		MH2	256..456	CDD:469593	69/217 (32%)