DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dad and Smad4

DIOPT Version :9

Sequence 1:NP_001369021.1 Gene:Dad / 42059 FlyBaseID:FBgn0020493 Length:665 Species:Drosophila melanogaster
Sequence 2:NP_062148.1 Gene:Smad4 / 50554 RGDID:3033 Length:552 Species:Rattus norvegicus


Alignment Length:566 Identity:133/566 - (23%)
Similarity:190/566 - (33%) Gaps:216/566 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   185 TESTSGSTLTIPVSTSRATAHPPQTQAQNGKRFREDF-----EALMKQLKRKQRNELLLAVKSRL 244
            |.:::.:.|:|        .|......|.|:  .|.|     |:|:|:||.|         |..|
  Rat     9 TPTSNDACLSI--------VHSLMCHRQGGE--SETFAKRAIESLVKKLKEK---------KDEL 54

  Fly   245 DPPTKTQRDVVEPTTTTAPTYLQCILI----PCKTQTVWE---PHVTASRLFFWRELWNAKELKR 302
            |       .::...||......:|:.|    ..:.|....   |||..:||:.|.:| :..|||.
  Rat    55 D-------SLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDL-HKNELKH 111

  Fly   303 LPTCPAARD--CIYMCCNPLHWFRI------LHQPETESPTPPYQRSKMLRLKDA---DFEED-- 354
            :..|..|.|  |..:|.||.|:.|:      |.....:|..||    .|| :||.   |||..  
  Rat   112 VKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPP----SML-VKDEYVHDFEGQPS 171

  Fly   355 -----------SQNDAKSAALSTWSA------------ESTSISNI------------------- 377
                       ....:..|:..|:||            .:|:..||                   
  Rat   172 LPTEGHSIQTIQHPPSNRASTETYSAPALLAPSESNATSTTNFPNIPVASTSQPASILAGSHSEG 236

  Fly   378 ------------------YKPALY--ESVT----------TDGKDHNINS--------------- 397
                              .:||.|  .|.|          |....|:.|.               
  Rat   237 LLQIASGPQPGQQQNGFTAQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHY 301

  Fly   398 -------------------QVWCQIAYWEMAHRVGEFFHAKTNAVNIYTDGIV-ASEVDSMCLRD 442
                               :.||.|||:||..:|||.|...::...:..||.| .|..|..||..
  Rat   302 WPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQ 366

  Fly   443 LTPAGNQIH--SVVPKARHTVGLGVTLSLE-NGDVWIYNRGNTTIFVDSPTLSENL-----DRVC 499
            |    :.:|  ..:.:||..:|.||.|..: .||||:....:..:||.|..|....     |.|.
  Rat   367 L----SNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVH 427

  Fly   500 KVMPGYCLKAFETNR---------------AELLSMRDHGHHPMGP------------------- 530
            |:.|...:|.|:..:               |...:....|:.| ||                   
  Rat   428 KIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIP-GPGSVGGIAPAISLSAAAGIG 491

  Fly   531 VDYFS----IKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQYL 572
            ||...    :::||.||||.||.||.|...|||:|:|. |.. |.|
  Rat   492 VDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHL-HRALQLL 536

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DadNP_001369021.1 MH1_SMAD_6_7 197..329 CDD:199813 39/151 (26%)
MH2_I-SMAD 400..565 CDD:199821 63/211 (30%)
Smad4NP_062148.1 Mediates interaction with ZBTB7A. /evidence=ECO:0000250|UniProtKB:Q13485 1..322 67/344 (19%)
MH1_SMAD_4 14..138 CDD:199816 40/150 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 167..193 2/25 (8%)
SAD 275..320 3/44 (7%)
MH2_SMAD_4 320..541 CDD:199823 66/223 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166337659
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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