DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dad and smad2

DIOPT Version :9

Sequence 1:	NP_001369021.1	Gene:	Dad / 42059	FlyBaseID:	FBgn0020493	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001011168.1	Gene:	smad2 / 496586	XenbaseID:	XB-GENE-482930	Length:	467	Species:	Xenopus tropicalis

Alignment Length:	502	Identity:	121/502 - (24%)
Similarity:	184/502 - (36%)	Gaps:	162/502 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 MISATTFTTMFRKCCGGATESTSGSTLTIPVSTSRATAHPPQTQAQNGKRFREDFEALMKQLKRK 231
            |.|...||....|...|..:|.||:|          .|...:...|..|...:..::|:|:||
Frog     1 MSSILPFTPPVVKRLLGWKKSPSGTT----------GAGGGEQNGQEEKWCEKAVKSLVKKLK-- 53

  Fly   232 QRNELLLAVKSRLDPPTKT-QRDVVEPTTTTAPTYLQCILIPCKTQTVWE--------------- 280
                             || |.|.:|...||.....:|:.||.....:|.
Frog    54 -----------------KTGQLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGL 101

  Fly   281 ----------------------PHVTASRLFFWRELWNAKELKRLPTCPAA----RDCIYMCCNP 319
                                  |||...||:.|.:|.:..|||.:..|..|    :|  .:|.||
Frog   102 YSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKD--EVCVNP 164

  Fly   320 LHWFRI--------------------------LH------------QPET----ESPTPPYQRSK 342
            .|:.|:                          .|            :|::    |:|.|.|
Frog   165 YHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGY---- 225

  Fly   343 MLRLKDADFEEDSQNDAK--SAALSTWSAESTSISNIYKPALYESVTTDGKDHNINSQ------- 398
                    ..||.:...:  :.::.|.|           ||.....|....:||::.|
Frog   226 --------ISEDGETSDQQLNQSMDTGS-----------PAELSPSTLSPVNHNLDLQPVTYSEP 271

  Fly   399 -VWCQIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHT 460
             .||.|||:|:..||||.|||...::.:  :||   .|..:..||..|:....  ::.|...|..
Frog   272 AFWCSIAYYELNQRVGETFHASQPSLTVDGFTD---PSNSERFCLGLLSNVNR--NATVEMTRRH 331

  Fly   461 VGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLD----RVCKVMPGYCLKAFETNR-AELLSM 520
            :|.||.|....|:|:.....::.|||.||..::...    .|||:.||..||.|.... |.||:.
Frog   332 IGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQ 396

  Fly   521 R-DHGHHPMGPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFS 565
            . :.|...:..:... :|::||.||||.:|:||.:...|||:|:|.:
Frog   397 SVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLN 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	37/211 (18%)
Dad	NP_001369021.1	MH2_I-SMAD	400..565	CDD:199821	59/173 (34%)
smad2	NP_001011168.1	MH1_SMAD_2_3	8..172	CDD:199815	43/194 (22%)
smad2	NP_001011168.1	MH2_SMAD_2_3	266..456	CDD:199826	59/183 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910