Protein Alignment Dad and smad1

DIOPT Version :9

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001007481.1
• Gene: smad1 / 493211
• XenbaseID: XB-GENE-1018193
• Length: 464
• Species: Xenopus tropicalis
• Alignment Length: 458
• Identity: 115/458 - (25%)
• Similarity: 182/458 - (39%)
• Gaps: 131/458 - (28%)

  Fly   222 EALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWE------ 280
            :||:|:||:|         |..::...|......:|:        .|:.||.......:
 Frog    35 DALVKKLKKK---------KGAMEELEKALSCPGQPS--------NCVTIPRSLDGRLQVSHRKG 82

  Fly   281 -PHVTASRLFFWRELWNAKELKRLPTC--PAARDCIYMCCNPLHWFRILHQPETESPT-PPY--- 338
             |||...|::.|.:|.:..|||.|..|  |.......:|.||.|:.|:      |||. ||.
 Frog    83 LPHVIYCRVWRWPDLQSHHELKPLECCEYPFGSKQKEVCINPYHYKRV------ESPVLPPVLVP 141

  Fly   339 -------QRSKMLRLK-----------DADFEEDSQ----------------NDAKSAALSTWSA 369
                   |.|.:.:.:           :|.|.:..|                |...|::....|.
 Frog   142 RHSEYNPQHSLLAQFRNLEPSEPHMPHNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSTYPHSP 206

  Fly   370 ESTSISNIYK------PALY----ESVTTDGKD--------HNINSQV---------------WC 401
            .|:...:.::      |..|    :.:|.|...        .||...:               ||
 Frog   207 ASSDPGSPFQIPADTPPPAYMPPEDQMTQDNSQPMDTNMMVPNIPQDINRADVQAVAYEEPKHWC 271

  Fly   402 QIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLG 464
            .|.|:|:.:||||.|||.:.:|.:  :||  .::..:..||..|:....  :|.:...|..:|.|
 Frog   272 SIVYYELNNRVGEAFHASSTSVLVDGFTD--PSNNRNRFCLGLLSNVNR--NSTIENTRRHIGKG 332

  Fly   465 VTLSLENGDVWIYNRGNTTIFVDS----------PTLSENLDRVCKVMPGYCLKAFETNR-AELL 518
            |.|....|:|:.....:::|||.|          ||      .|||:..|..||.|.... |:||
 Frog   333 VHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPT------TVCKIPSGCSLKIFNNQEFAQLL 391

  Fly   519 SMR-DHGHHPMGPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQYL--MLARSAG 579
            :.. :||...:..:... :|::||.||||.:|.|||:...|||:|:|. |...|:|  :|.:...
 Frog   392 AQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL-HGPLQWLDKVLTQMGS 455

  Fly   580 PHS 582
            ||:
 Frog   456 PHN 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	29/115 (25%)
		MH2_I-SMAD	400..565	CDD:199821	60/179 (34%)
smad1	NP_001007481.1	MH1_SMAD_1_5_9	9..132	CDD:199814	29/119 (24%)
		FAM70	<132..229	CDD:373433	15/96 (16%)
		MH2_SMAD_1_5_9	264..464	CDD:199822	66/206 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910