DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dad and smad9

DIOPT Version :9

Sequence 1:	NP_001369021.1	Gene:	Dad / 42059	FlyBaseID:	FBgn0020493	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001315428.1	Gene:	smad9 / 445564	ZFINID:	ZDB-GENE-031014-1	Length:	466	Species:	Danio rerio

Alignment Length:	512	Identity:	126/512 - (24%)
Similarity:	201/512 - (39%)	Gaps:	148/512 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 MISATTFTTMFRKCCGGATESTSGSTLTIPVSTSRATAHPPQTQAQNGKRFRED-FEALMKQLKR 230
            |.|:|:.|::|              :.|.| :..|...   ..|....:::.|. .::|:|:||:
Zfish     1 MHSSTSITSLF--------------SFTSP-AVKRLLG---WKQGDEEEKWAEKAVDSLVKKLKK 47

  Fly   231 KQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWE-------PHVTASRL 288
            |         |..::...|......:|:        :|:.||.......:       |||...|:
Zfish    48 K---------KGAMEELEKALSCPGQPS--------KCVTIPRSLDGRLQVSHRKGLPHVIYCRV 95

  Fly   289 FFWRELWNAKELKRLPTC--PAARDCIYMCCNPLHWFRILHQPETESPT-PPY----------QR 340
            :.|.:|.:..|||.|..|  |.......:|.||.|:.|:      |:|. ||.          |.
Zfish    96 WRWPDLQSHHELKALDCCEFPFGSKQKEICINPYHYRRV------ETPVLPPVLVPRHSEFNPQH 154

  Fly   341 SKMLRLKDADFEED---SQN----DAKSAALSTWSAESTSISNIYKPALY------ESVTTDGKD 392
            |.:.:.::|....:   .||    |:..|...:..:.|.|.|....||.:      .|.|..|..
Zfish   155 SLLAKFRNASLHNEPLMPQNATFPDSFPAMPCSSFSSSPSSSLNPSPAAHSFPNSPSSATEPGSP 219

  Fly   393 HNINSQV---------------------------------------------WCQIAYWEMAHRV 412
            :.|.::.                                             ||.:||:|:.:||
Zfish   220 YQITAETPPPPYSMMESSPSEDVKPAESSENKLILTAPQRDLRPVCYEEPEYWCSVAYYELNNRV 284

  Fly   413 GEFFHAKTNAVNIYTDGIV--ASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLENGDVW 475
            ||.|||  :|.:|..||..  ::..:..||..|:....  :|.:...|..:|.||.|....|:|:
Zfish   285 GETFHA--SARSILVDGFTDPSNNKNRFCLGLLSNVNR--NSTIEHTRRHIGKGVHLYYVGGEVY 345

  Fly   476 IYNRGNTTIFVDS----------PTLSENLDRVCKVMPGYCLKAFETNR-AELLSMR-DHGHHPM 528
            .....:::|||.|          ||      .|||:..|..||.|.... |:|||.. :||...:
Zfish   346 AECLSDSSIFVQSRNCNYQHGFHPT------TVCKIPSGCSLKIFNNQLFAQLLSQSVNHGFEVV 404

  Fly   529 GPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQYL--MLARSAGPHS 582
            ..:... :|::||.||||.:|.|||:...|||:|:|. |...|:|  :|.:...||:
Zfish   405 YELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL-HGPLQWLDKVLTQMGSPHN 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	31/141 (22%)
Dad	NP_001369021.1	MH2_I-SMAD	400..565	CDD:199821	62/179 (35%)
smad9	NP_001315428.1	MH1_SMAD_1_5_9	13..136	CDD:199814	33/149 (22%)
smad9	NP_001315428.1	MH2_SMAD_1_5_9	266..466	CDD:199822	68/206 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910