Protein Alignment Dad and smad9

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001315428.1
• Gene: smad9 / 445564
• ZFINID: ZDB-GENE-031014-1
• Length: 466
• Species: Danio rerio
• Alignment Length: 512
• Identity: 126/512 - (24%)
• Similarity: 201/512 - (39%)
• Gaps: 148/512 - (28%)

  Fly   167 MISATTFTTMFRKCCGGATESTSGSTLTIPVSTSRATAHPPQTQAQNGKRFRED-FEALMKQLKR 230
            |.|:|:.|::|              :.|.| :..|...   ..|....:::.|. .::|:|:||:
Zfish     1 MHSSTSITSLF--------------SFTSP-AVKRLLG---WKQGDEEEKWAEKAVDSLVKKLKK 47

  Fly   231 KQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWE-------PHVTASRL 288
            |         |..::...|......:|:        :|:.||.......:       |||...|:
Zfish    48 K---------KGAMEELEKALSCPGQPS--------KCVTIPRSLDGRLQVSHRKGLPHVIYCRV 95

  Fly   289 FFWRELWNAKELKRLPTC--PAARDCIYMCCNPLHWFRILHQPETESPT-PPY----------QR 340
            :.|.:|.:..|||.|..|  |.......:|.||.|:.|:      |:|. ||.          |.
Zfish    96 WRWPDLQSHHELKALDCCEFPFGSKQKEICINPYHYRRV------ETPVLPPVLVPRHSEFNPQH 154

  Fly   341 SKMLRLKDADFEED---SQN----DAKSAALSTWSAESTSISNIYKPALY------ESVTTDGKD 392
            |.:.:.::|....:   .||    |:..|...:..:.|.|.|....||.:      .|.|..|..
Zfish   155 SLLAKFRNASLHNEPLMPQNATFPDSFPAMPCSSFSSSPSSSLNPSPAAHSFPNSPSSATEPGSP 219

  Fly   393 HNINSQV---------------------------------------------WCQIAYWEMAHRV 412
            :.|.::.                                             ||.:||:|:.:||
Zfish   220 YQITAETPPPPYSMMESSPSEDVKPAESSENKLILTAPQRDLRPVCYEEPEYWCSVAYYELNNRV 284

  Fly   413 GEFFHAKTNAVNIYTDGIV--ASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLENGDVW 475
            ||.|||  :|.:|..||..  ::..:..||..|:....  :|.:...|..:|.||.|....|:|:
Zfish   285 GETFHA--SARSILVDGFTDPSNNKNRFCLGLLSNVNR--NSTIEHTRRHIGKGVHLYYVGGEVY 345

  Fly   476 IYNRGNTTIFVDS----------PTLSENLDRVCKVMPGYCLKAFETNR-AELLSMR-DHGHHPM 528
            .....:::|||.|          ||      .|||:..|..||.|.... |:|||.. :||...:
Zfish   346 AECLSDSSIFVQSRNCNYQHGFHPT------TVCKIPSGCSLKIFNNQLFAQLLSQSVNHGFEVV 404

  Fly   529 GPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQYL--MLARSAGPHS 582
            ..:... :|::||.||||.:|.|||:...|||:|:|. |.. |:|  :|.:...||:
Zfish   405 YELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL-HGPLQWLDKVLTQMGSPHN 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	31/141 (22%)
		MH2_I-SMAD	400..565	CDD:199821	62/179 (35%)
smad9	NP_001315428.1	MH1_SMAD_1_5_9	13..136	CDD:199814	33/149 (22%)
		MH2_SMAD_1_5_9	266..466	CDD:199822	68/206 (33%)