Protein Alignment Dad and Med

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Alignment Length: 688
• Identity: 146/688 - (21%)
• Similarity: 195/688 - (28%)
• Gaps: 289/688 - (42%)

  Fly    19 PSNGVSAA------PPAQPPR--PPPPPHRPRPHQCTPSFGYSCNEEDSLAMRQTPLPPYSSIAC 75
            |.:||:.:      ||  |||  .||...:.:|.|                  |||.|..
  Fly   251 PQDGVAGSRGSWMVPP--PPRLGQPPQQQQQQPQQ------------------QTPQPTQ----- 290

  Fly    76 GMDCSSSNSSSCGQSLSLSQGQGHNNNNSHPYRRLPNHMD-----VLPPPPSACD---------- 125
                         |..:.||...|:....|....:|..|:     ..||||....
  Fly   291 -------------QQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHT 342

  Fly   126 --RCCTAPGYSCASSCDDMLIDGSDLDQDRSPDQ----------------------GQVQPVDRR 166
              ...|.|..:.|..............|.:...|                      ||..||
  Fly   343 QANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPV--- 404

  Fly   167 MISATTFTTMFRKCCGGATE-------------STSGSTLTIPVSTSR--ATAHPPQTQAQNGKR 216
                    :..:...||.|.             |..||..:.||....  .||.|...|.|
  Fly   405 --------SQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQ---- 457

  Fly   217 FREDFEALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVE-----------PTTTTAP---TYLQ 267
                                        .|||..|.:...           ..|.|.|   ||
  Fly   458 ----------------------------QPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTY-- 492

  Fly   268 CILIPCKTQTVWEPHVTASRLFFWRELWNAKELKRLPTCPAARDCIYMCCNPLHWFRILHQPETE 332
                   ||::..|...:....||....:..                           |..|:
  Fly   493 -------TQSMQPPDPRSLPGGFWNSSLSGD---------------------------LGSPQ-- 521

  Fly   333 SPTPPYQRSKMLRLKDADFEEDSQNDAKSAALSTWSAESTSISNIYKPALYESVTTDGKDHNINS 397
             .|||.|:               |...:...||.           ..|..|
  Fly   522 -QTPPQQQ---------------QQQQQPRLLSR-----------QPPPEY-------------- 545

  Fly   398 QVWCQIAYWEMAHRVGEFFHAKTNAVNIYTDGIV-ASEVDSMCLRDLTPAGNQIHSV--VPKARH 459
              ||.|||:|:..:|||.|...:...|:..||.| .|..:..||..|    :.:|..  ..:||.
  Fly   546 --WCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGAL----SNVHRTEQSERARL 604

  Fly   460 TVGLGVTLSLE-NGDVWIYNRGNTTIFVDSPTLSENL-----DRVCKVMPGYCLKAFE------- 511
            .:|.||.|.|. .||||:....:.::||.|..|....     |.|.|:.|..|:|.|:
  Fly   605 HIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQ 669

  Fly   512 -----TN-----RAELLSMRDHGHHPMG------------PVDYFS----IKISFGKGWGRDYKR 550
                 ||     .|:..::....:..||            .||...    :::||.||||.||.|
  Fly   670 MHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPR 734

  Fly   551 QDIMGCPCWLEVHFSHLRXQYLMLARSA----GPHSAS 584
            |.|...|||:|||. |.. |.|.....|    ||.:|:
  Fly   735 QSIKETPCWIEVHL-HRALQLLDEVLHAMPIDGPRAAA 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	21/147 (14%)
		MH2_I-SMAD	400..565	CDD:199821	65/206 (32%)
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816
		MH2_SMAD_4	543..760	CDD:199823	69/237 (29%)