Protein Alignment Dad and SMAD6

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_005576.3
• Gene: SMAD6 / 4091
• HGNCID: 6772
• Length: 496
• Species: Homo sapiens
• Alignment Length: 563
• Identity: 162/563 - (28%)
• Similarity: 215/563 - (38%)
• Gaps: 149/563 - (26%)

  Fly    55 NEEDSLAMRQTPLPPYSSIACGMDCSSSNSSSCGQS---------------LSLSQGQGHNNNNS 104
            :|:.||..|..|.|           .:.....||:|               ...:||.|......
Human    34 DEDGSLGSRAEPAP-----------RAREGGGCGRSEVRPVAPRRPRDAVGQRGAQGAGRRRRAG 87

  Fly   105 HPYRRLPNHMDVLPPPPSACDRCCTAPGYSCASSCDDMLIDGSDLDQDRSPDQGQVQPVDRRMIS 169
            .|           |.|.|       .||....||..|:...|.         .|.:...|...::
Human    88 GP-----------PRPMS-------EPGAGAGSSLLDVAEPGG---------PGWLPESDCETVT 125

  Fly   170 ATTFTTMFRKCCGG---ATESTSGSTLTIPVSTSRATAHPPQTQAQNGKRFREDFE--------- 222
            ...|:.  |...|.   |::..:|:.|                :...|.|.||...
Human   126 CCLFSE--RDAAGAPRDASDPLAGAAL----------------EPAGGGRSREARSRLLLLEQEL 172

  Fly   223 -----ALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVW--- 279
                 :|:|:||.:..:.||.||:||...|.                  .|:|:|.....:.
Human   173 KTVTYSLLKRLKERSLDTLLEAVESRGGVPG------------------GCVLVPRADLRLGGQP 219

  Fly   280 -EPHVTASRLFFWRELWNAKELKRLPTC---PAARDCIYMCCNPLHWFRILHQPETESPTPPYQR 340
             .|.:...|||.|.:|.:|.|||.|..|   .||.|...:||||.|:.|:.   ..|||.|||.
Human   220 APPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLC---GPESPPPPYS- 280

  Fly   341 SKMLRLKDADFEEDSQNDAKSAALSTWSAESTSISNIYKPALYE--SVTTDG--KDHNINSQVWC 401
                ||...|  |....|...:.||....|:|: |.|..|..:.  |::.|.  ..|      ||
Human   281 ----RLSPRD--EYKPLDLSDSTLSYTETEATN-SLITAPGEFSDASMSPDATKPSH------WC 332

  Fly   402 QIAYWEMAHRVGEFFHAKTNAVNIYTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVT 466
            .:||||...|||..:.....||:|:.|   ..:....||..|..  .|....|.:.|..:|.|:.
Human   333 SVAYWEHRTRVGRLYAVYDQAVSIFYD---LPQGSGFCLGQLNL--EQRSESVRRTRSKIGFGIL 392

  Fly   467 LSLENGDVWIYNRGNTTIFVDSPTLSENLDR---VCKVMPGYCLKAFETNRAELLSMRDHGHHP- 527
            ||.|...||.||||...|||:||||.....|   |.||.|||.:|.|:..|:.|    .|...|
Human   393 LSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGL----QHAPEPD 453

  Fly   528 --MGPVDYFSIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLR 568
              .||.|..|::|||.||||..|.||.|..||||||:..::.|
Human   454 AADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	39/152 (26%)
		MH2_I-SMAD	400..565	CDD:199821	71/170 (42%)
SMAD6	NP_005576.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..116		23/119 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	136..156		4/35 (11%)
		MH1_SMAD_6	160..273	CDD:199817	36/133 (27%)
		MH2_SMAD_6	322..494	CDD:199824	73/186 (39%)