Protein Alignment Dad and SMAD5

DIOPT Version :9

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001001419.1
• Gene: SMAD5 / 4090
• HGNCID: 6771
• Length: 465
• Species: Homo sapiens
• Alignment Length: 466
• Identity: 113/466 - (24%)
• Similarity: 172/466 - (36%)
• Gaps: 151/466 - (32%)

  Fly   222 EALMKQLKRKQ--RNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWE---- 280
            :||:|:||:|:  ..||..|:.|...|.                   :|:.||.......:
Human    36 DALVKKLKKKKGAMEELEKALSSPGQPS-------------------KCVTIPRSLDGRLQVSHR 81

  Fly   281 ---PHVTASRLFFWRELWNAKELKRLPTC--PAARDCIYMCCNPLHWFRI--------------- 325
               |||...|::.|.:|.:..|||.|..|  |.......:|.||.|:.|:
Human    82 KGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNE 146

  Fly   326 ------------------------------LHQPET-------ESPTPP------YQRSKMLRLK 347
                                          .|||..       .||.||      |..|......
Human   147 FNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPYPPSPASSTYPNSPASSGP 211

  Fly   348 DADFE-------------EDSQNDAKSAALSTWSAESTSISNIYKPALYESVTT--------DGK 391
            .:.|:             :|......|..:.|        ||...|.:..|:::        :..
Human   212 GSPFQLPADTPPPAYMPPDDQMGQDNSQPMDT--------SNNMIPQIMPSISSRDVQPVAYEEP 268

  Fly   392 DHNINSQVWCQIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCLRDLTPAGNQIHSVV 454
            .|      ||.|.|:|:.:||||.|||.:.:|.:  :||  .::.....||..|:....  :|.:
Human   269 KH------WCSIVYYELNNRVGEAFHASSTSVLVDGFTD--PSNNKSRFCLGLLSNVNR--NSTI 323

  Fly   455 PKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDS----------PTLSENLDRVCKVMPGYCLKA 509
            ...|..:|.||.|....|:|:.....:::|||.|          ||      .|||:.....||.
Human   324 ENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPT------TVCKIPSSCSLKI 382

  Fly   510 FETNR-AELLSMR-DHGHHPMGPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQY 571
            |.... |:||:.. :||...:..:... :|::||.||||.:|.|||:...|||:|:|. |.. |:
Human   383 FNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL-HGPLQW 446

  Fly   572 L--MLARSAGP 580
            |  :|.:...|
Human   447 LDKVLTQMGSP 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	32/162 (20%)
		MH2_I-SMAD	400..565	CDD:199821	59/179 (33%)
SMAD5	NP_001001419.1	MH1_SMAD_1_5_9	10..133	CDD:199814	31/115 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..249		15/93 (16%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	65/210 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810