DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dad and SMAD3

DIOPT Version :9

Sequence 1:	NP_001369021.1	Gene:	Dad / 42059	FlyBaseID:	FBgn0020493	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_005893.1	Gene:	SMAD3 / 4088	HGNCID:	6769	Length:	425	Species:	Homo sapiens

Alignment Length:	392	Identity:	108/392 - (27%)
Similarity:	164/392 - (41%)	Gaps:	89/392 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 AVKSRLDPPTKT-QRDVVEPTTTTAPTYLQCILIPCKTQTVWE-------PHVTASRLFFWRELW 295
            ||||.:....|| |.|.:|...||.....:||.||.......:       |||...||:.|.:|.
Human    34 AVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLH 98

  Fly   296 NAKELKRLPTCPAA----RDCIYMCCNPLHWFRILHQPETESPT-PPYQRSKMLRLKDADFEEDS 355
            :..||:.:..|..|    :|  .:|.||.|:.|:      |:|. ||..           ....:
Human    99 SHHELRAMELCEFAFNMKKD--EVCVNPYHYQRV------ETPVLPPVL-----------VPRHT 144

  Fly   356 QNDAKSAALSTWS---AESTSI-------SNIYK--PALYESVTTDGKDHNINSQV--------- 399
            :..|:...|..:|   .|:|:.       |||.:  |..|.|...:..||.:|..:
Human   145 EIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSP 209

  Fly   400 ----------------------WCQIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCL 440
                                  ||.|:|:|:..||||.|||...::.:  :||   .|..:..||
Human   210 NPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTD---PSNSERFCL 271

  Fly   441 RDLTPAGNQIHSVVPKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLD----RVCKV 501
            ..|:....  ::.|...|..:|.||.|....|:|:.....::.|||.||..::...    .|||:
Human   272 GLLSNVNR--NAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKI 334

  Fly   502 MPGYCLKAFETNR-AELLSMR-DHGHHPMGPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVH 563
            .||..||.|.... |.||:.. :.|...:..:... :|::||.||||.:|:||.:...|||:|:|
Human   335 PPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELH 399

  Fly   564 FS 565
            .:
Human   400 LN 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	32/101 (32%)
Dad	NP_001369021.1	MH2_I-SMAD	400..565	CDD:199821	58/173 (34%)
SMAD3	NP_005893.1	MH1_SMAD_2_3	8..132	CDD:199815	32/105 (30%)
		Linker	137..231		15/104 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..208		9/42 (21%)
		MH2_SMAD_2_3	224..414	CDD:199826	58/183 (32%)
		Sufficient for interaction with XPO4. /evidence=ECO:0000269\|PubMed:16449645	271..324		15/54 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810