Protein Alignment Dad and SMAD2

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_005892.1
• Gene: SMAD2 / 4087
• HGNCID: 6768
• Length: 467
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 118/510 - (23%)
• Similarity: 186/510 - (36%)
• Gaps: 182/510 - (35%)

  Fly   162 PVDRRMISATTFTTMFRKCCGGATESTSGSTLTIPVSTSRATAHPPQTQAQNG---KRFREDFEA 223
            ||.:|::.       ::|..||:..:..|.                    |||   |...:..::
Human    10 PVVKRLLG-------WKKSAGGSGGAGGGE--------------------QNGQEEKWCEKAVKS 47

  Fly   224 LMKQLKRKQRNELLLAVKSRLDPPTKTQR-DVVEPTTTTAPTYLQCILIPCKTQTVWE------- 280
            |:|:||                   ||.| |.:|...||.....:|:.||.....:|.
Human    48 LVKKLK-------------------KTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTI 93

  Fly   281 ------------------------------PHVTASRLFFWRELWNAKELKRLPTCPAA----RD 311
                                          |||...||:.|.:|.:..|||.:..|..|    :|
Human    94 DQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKD 158

  Fly   312 CIYMCCNPLHWFRI--------------------------LH------------QPET----ESP 334
              .:|.||.|:.|:                          .|            :|::    |:|
Human   159 --EVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETP 221

  Fly   335 TPPYQRSKMLRLKDADFEEDSQNDAK--SAALSTWSAESTSISNIYKPALYESVTTDGKDHNINS 397
            .|.|            ..||.:...:  :.::.|.|           ||.....|....:|:::.
Human   222 PPGY------------ISEDGETSDQQLNQSMDTGS-----------PAELSPTTLSPVNHSLDL 263

  Fly   398 Q--------VWCQIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCLRDLTPAGNQIHS 452
            |        .||.|||:|:..||||.|||...::.:  :||   .|..:..||..|:....  ::
Human   264 QPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTD---PSNSERFCLGLLSNVNR--NA 323

  Fly   453 VVPKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLD----RVCKVMPGYCLKAFETN 513
            .|...|..:|.||.|....|:|:.....::.|||.||..::...    .|||:.||..||.|...
Human   324 TVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQ 388

  Fly   514 R-AELLSMR-DHGHHPMGPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFS 565
            . |.||:.. :.|...:..:... :|::||.||||.:|:||.:...|||:|:|.:
Human   389 EFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLN 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	38/214 (18%)
		MH2_I-SMAD	400..565	CDD:199821	59/173 (34%)
SMAD2	NP_005892.1	MH1_SMAD_2_3	8..172	CDD:199815	44/209 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..251		11/66 (17%)
		PY-motif	221..225		2/3 (67%)
		MH2_SMAD_2_3	266..456	CDD:199826	59/183 (32%)