DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dad and SMAD2

DIOPT Version :9

Sequence 1:NP_001369021.1 Gene:Dad / 42059 FlyBaseID:FBgn0020493 Length:665 Species:Drosophila melanogaster
Sequence 2:NP_001003652.1 Gene:SMAD2 / 4087 HGNCID:6768 Length:467 Species:Homo sapiens


Alignment Length:510 Identity:118/510 - (23%)
Similarity:186/510 - (36%) Gaps:182/510 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 PVDRRMISATTFTTMFRKCCGGATESTSGSTLTIPVSTSRATAHPPQTQAQNG---KRFREDFEA 223
            ||.:|::.       ::|..||:..:..|.                    |||   |...:..::
Human    10 PVVKRLLG-------WKKSAGGSGGAGGGE--------------------QNGQEEKWCEKAVKS 47

  Fly   224 LMKQLKRKQRNELLLAVKSRLDPPTKTQR-DVVEPTTTTAPTYLQCILIPCKTQTVWE------- 280
            |:|:||                   ||.| |.:|...||.....:|:.||.....:|.       
Human    48 LVKKLK-------------------KTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTI 93

  Fly   281 ------------------------------PHVTASRLFFWRELWNAKELKRLPTCPAA----RD 311
                                          |||...||:.|.:|.:..|||.:..|..|    :|
Human    94 DQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKD 158

  Fly   312 CIYMCCNPLHWFRI--------------------------LH------------QPET----ESP 334
              .:|.||.|:.|:                          .|            :|::    |:|
Human   159 --EVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETP 221

  Fly   335 TPPYQRSKMLRLKDADFEEDSQNDAK--SAALSTWSAESTSISNIYKPALYESVTTDGKDHNINS 397
            .|.|            ..||.:...:  :.::.|.|           ||.....|....:|:::.
Human   222 PPGY------------ISEDGETSDQQLNQSMDTGS-----------PAELSPTTLSPVNHSLDL 263

  Fly   398 Q--------VWCQIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCLRDLTPAGNQIHS 452
            |        .||.|||:|:..||||.|||...::.:  :||   .|..:..||..|:....  ::
Human   264 QPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTD---PSNSERFCLGLLSNVNR--NA 323

  Fly   453 VVPKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLD----RVCKVMPGYCLKAFETN 513
            .|...|..:|.||.|....|:|:.....::.|||.||..::...    .|||:.||..||.|...
Human   324 TVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQ 388

  Fly   514 R-AELLSMR-DHGHHPMGPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFS 565
            . |.||:.. :.|...:..:... :|::||.||||.:|:||.:...|||:|:|.:
Human   389 EFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLN 443

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DadNP_001369021.1 MH1_SMAD_6_7 197..329 CDD:199813 38/214 (18%)
MH2_I-SMAD 400..565 CDD:199821 59/173 (34%)
SMAD2NP_001003652.1 MH1_SMAD_2_3 8..172 CDD:199815 44/209 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..251 11/66 (17%)
PY-motif 221..225 2/3 (67%)
MH2_SMAD_2_3 266..456 CDD:199826 59/183 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3701
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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