DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dad and SMAD1

DIOPT Version :9

Sequence 1:	NP_001369021.1	Gene:	Dad / 42059	FlyBaseID:	FBgn0020493	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001003688.1	Gene:	SMAD1 / 4086	HGNCID:	6767	Length:	465	Species:	Homo sapiens

Alignment Length:	459	Identity:	115/459 - (25%)
Similarity:	185/459 - (40%)	Gaps:	132/459 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 EALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWE------ 280
            :||:|:||:|         |..::...|......:|:        .|:.||.......:
Human    35 DALVKKLKKK---------KGAMEELEKALSCPGQPS--------NCVTIPRSLDGRLQVSHRKG 82

  Fly   281 -PHVTASRLFFWRELWNAKELKRLPTC--PAARDCIYMCCNPLHWFRILHQPETESPT-PPY--- 338
             |||...|::.|.:|.:..|||.|..|  |.......:|.||.|:.|:      |||. ||.
Human    83 LPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRV------ESPVLPPVLVP 141

  Fly   339 -------QRSKMLRLKDA---------------DFEEDSQNDAKSAALSTWSAESTSISNIY--- 378
                   |.|.:.:.::.               .|::.:.:....:..|::.....|.|:.|
Human   142 RHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHS 206

  Fly   379 ----------------KPALY----ESVTTDGK---DHN-----INSQV---------------W 400
                            .|..|    :.:|.||.   |.|     :.|::               |
Human   207 PTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPSEINRGDVQAVAYEEPKHW 271

  Fly   401 CQIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVGL 463
            |.|.|:|:.:||||.|||.:.:|.:  :||  .::..:..||..|:....  :|.:...|..:|.
Human   272 CSIVYYELNNRVGEAFHASSTSVLVDGFTD--PSNNKNRFCLGLLSNVNR--NSTIENTRRHIGK 332

  Fly   464 GVTLSLENGDVWIYNRGNTTIFVDS----------PTLSENLDRVCKVMPGYCLKAFETNR-AEL 517
            ||.|....|:|:.....:::|||.|          ||      .|||:..|..||.|.... |:|
Human   333 GVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPT------TVCKIPSGCSLKIFNNQEFAQL 391

  Fly   518 LSMR-DHGHHPMGPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQYL--MLARSA 578
            |:.. :||...:..:... :|::||.||||.:|.|||:...|||:|:|. |.. |:|  :|.:..
Human   392 LAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL-HGPLQWLDKVLTQMG 455

  Fly   579 GPHS 582
            .||:
Human   456 SPHN 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	29/115 (25%)
Dad	NP_001369021.1	MH2_I-SMAD	400..565	CDD:199821	60/179 (34%)
SMAD1	NP_001003688.1	MH1_SMAD_1_5_9	9..132	CDD:199814	29/119 (24%)
		PRK10263	<133..>244	CDD:236669	15/110 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..248		12/85 (14%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	66/206 (32%)
		L3 loop. /evidence=ECO:0000269\|PubMed:11779505	418..428		6/9 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810