DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dad and Smad6

DIOPT Version :9

Sequence 1:NP_001369021.1 Gene:Dad / 42059 FlyBaseID:FBgn0020493 Length:665 Species:Drosophila melanogaster
Sequence 2:NP_001102472.2 Gene:Smad6 / 367100 RGDID:1305069 Length:495 Species:Rattus norvegicus


Alignment Length:567 Identity:166/567 - (29%)
Similarity:220/567 - (38%) Gaps:147/567 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 GYSC--NEEDSLAMRQTPLPPYSSIACGMDCSSSNSSSCGQSLSLSQGQGHNNNNSHPYRRLPNH 113
            |..|  :|:.||..|..|.|           .:.....||:|          ...|...|||   
  Rat    27 GGGCGGDEDGSLGSRAEPAP-----------RAREGGGCGRS----------EVRSVAPRRL--- 67

  Fly   114 MDVLPP--------------PPSACDRCCTAPGYSCASSCDDMLIDGSDLDQDRSPDQGQVQPVD 164
            .|.:.|              ||    |..:.||....         ||.||.......|.:...|
  Rat    68 RDAVGPRGALIAGRRRRTGGPP----RPVSEPGAGAG---------GSPLDVVEPGGPGWLPESD 119

  Fly   165 RRMISATTFTTMFRKCCGGATESTSGSTLTIPVSTSRATAHP-----PQTQAQNGKRFREDFE-- 222
            ...::          ||..:....:|:        .|.:..|     |:.:...|.|.||...  
  Rat   120 CETVT----------CCLFSERDAAGA--------PRDSGDPQARQSPEPEEGGGPRSREARSRL 166

  Fly   223 ------------ALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKT 275
                        :|:|:||.:..:.||.||:||...|.                  .|:|:|...
  Rat   167 LLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPG------------------GCVLVPRAD 213

  Fly   276 QTVW----EPHVTASRLFFWRELWNAKELKRLPTC---PAARDCIYMCCNPLHWFRILHQPETES 333
            ..:.    .|.:...|||.|.:|.:|.|||.|..|   .||.|...:||||.|:.|:.   ..||
  Rat   214 LRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLC---GPES 275

  Fly   334 PTPPYQRSKMLRLKDADFEEDSQNDAKSAALSTWSAESTSISNIYKPALYE--SVTTDG--KDHN 394
            |.|||.     ||...|  :....|...:.||....|:|: |.|..|..:.  |::.|.  ..| 
  Rat   276 PPPPYS-----RLSPPD--QHKPLDLSDSTLSYTETEATN-SLITAPGEFSDASMSPDATKPSH- 331

  Fly   395 INSQVWCQIAYWEMAHRVGEFFHAKTNAVNIYTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARH 459
                 ||.:||||...|||..:.....||:|:.|   ..:....||..|..  .|....|.:.|.
  Rat   332 -----WCSVAYWEHRTRVGRLYAVYDQAVSIFYD---LPQGSGFCLGQLNL--EQRSESVRRTRS 386

  Fly   460 TVGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLDR---VCKVMPGYCLKAFETNRAELLSMR 521
            .:|.|:.||.|...||.||||...|||:||||.....|   |.||.|||.:|.|:..|:.||...
  Rat   387 KIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLLQHA 451

  Fly   522 DHGHHPMGPVDYFSIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLR 568
            |..|   ||.|..|::|||.||||..|.||.|..||||||:..::.|
  Rat   452 DAAH---GPYDPHSVRISFAKGWGPCYSRQFITSCPCWLEILLNNHR 495

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DadNP_001369021.1 MH1_SMAD_6_7 197..329 CDD:199813 42/157 (27%)
MH2_I-SMAD 400..565 CDD:199821 72/167 (43%)
Smad6NP_001102472.2 MH1_SMAD_6 161..274 CDD:199817 36/133 (27%)
MH2_SMAD_6 323..493 CDD:199824 74/183 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 113 1.000 Domainoid score I5981
eggNOG 1 0.900 - - E1_KOG3701
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 147 1.000 Inparanoid score I4315
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D193735at33208
OrthoFinder 1 1.000 - - FOG0003707
OrthoInspector 1 1.000 - - otm44627
orthoMCL 1 0.900 - - OOG6_109794
Panther 1 1.100 - - LDO PTHR13703
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X6247
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1211.830

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