Protein Alignment Dad and Smad6

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001102472.2
• Gene: Smad6 / 367100
• RGDID: 1305069
• Length: 495
• Species: Rattus norvegicus
• Alignment Length: 567
• Identity: 166/567 - (29%)
• Similarity: 220/567 - (38%)
• Gaps: 147/567 - (25%)

  Fly    51 GYSC--NEEDSLAMRQTPLPPYSSIACGMDCSSSNSSSCGQSLSLSQGQGHNNNNSHPYRRLPNH 113
            |..|  :|:.||..|..|.|           .:.....||:|          ...|...|||
  Rat    27 GGGCGGDEDGSLGSRAEPAP-----------RAREGGGCGRS----------EVRSVAPRRL--- 67

  Fly   114 MDVLPP--------------PPSACDRCCTAPGYSCASSCDDMLIDGSDLDQDRSPDQGQVQPVD 164
            .|.:.|              ||    |..:.||....         ||.||.......|.:...|
  Rat    68 RDAVGPRGALIAGRRRRTGGPP----RPVSEPGAGAG---------GSPLDVVEPGGPGWLPESD 119

  Fly   165 RRMISATTFTTMFRKCCGGATESTSGSTLTIPVSTSRATAHP-----PQTQAQNGKRFREDFE-- 222
            ...::          ||..:....:|:        .|.:..|     |:.:...|.|.||...
  Rat   120 CETVT----------CCLFSERDAAGA--------PRDSGDPQARQSPEPEEGGGPRSREARSRL 166

  Fly   223 ------------ALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKT 275
                        :|:|:||.:..:.||.||:||...|.                  .|:|:|...
  Rat   167 LLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPG------------------GCVLVPRAD 213

  Fly   276 QTVW----EPHVTASRLFFWRELWNAKELKRLPTC---PAARDCIYMCCNPLHWFRILHQPETES 333
            ..:.    .|.:...|||.|.:|.:|.|||.|..|   .||.|...:||||.|:.|:.   ..||
  Rat   214 LRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLC---GPES 275

  Fly   334 PTPPYQRSKMLRLKDADFEEDSQNDAKSAALSTWSAESTSISNIYKPALYE--SVTTDG--KDHN 394
            |.|||.     ||...|  :....|...:.||....|:|: |.|..|..:.  |::.|.  ..|
  Rat   276 PPPPYS-----RLSPPD--QHKPLDLSDSTLSYTETEATN-SLITAPGEFSDASMSPDATKPSH- 331

  Fly   395 INSQVWCQIAYWEMAHRVGEFFHAKTNAVNIYTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARH 459
                 ||.:||||...|||..:.....||:|:.|   ..:....||..|..  .|....|.:.|.
  Rat   332 -----WCSVAYWEHRTRVGRLYAVYDQAVSIFYD---LPQGSGFCLGQLNL--EQRSESVRRTRS 386

  Fly   460 TVGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLDR---VCKVMPGYCLKAFETNRAELLSMR 521
            .:|.|:.||.|...||.||||...|||:||||.....|   |.||.|||.:|.|:..|:.||...
  Rat   387 KIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLLQHA 451

  Fly   522 DHGHHPMGPVDYFSIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLR 568
            |..|   ||.|..|::|||.||||..|.||.|..||||||:..::.|
  Rat   452 DAAH---GPYDPHSVRISFAKGWGPCYSRQFITSCPCWLEILLNNHR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	42/157 (27%)
		MH2_I-SMAD	400..565	CDD:199821	72/167 (43%)
Smad6	NP_001102472.2	MH1_SMAD_6	161..274	CDD:199817	36/133 (27%)
		MH2_SMAD_6	323..493	CDD:199824	74/183 (40%)