Protein Alignment Dad and smad7

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_778257.2
• Gene: smad7 / 326282
• ZFINID: ZDB-GENE-030128-3
• Length: 372
• Species: Danio rerio
• Alignment Length: 434
• Identity: 127/434 - (29%)
• Similarity: 186/434 - (42%)
• Gaps: 95/434 - (21%)

  Fly   151 QDRSPDQGQVQPVDRRMISATTFTTMFRKCCGGATESTSGSTLTIPVSTSRATAHPPQTQAQNGK 215
            :.|:|.:|:                      |.|...|.|.|    .....|:...|.|:|:
Zfish    15 RSRAPVEGE----------------------GDADTGTRGGT----AGCCLASKPNPGTEAE--- 50

  Fly   216 RFREDFEALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWE 280
             .:....:::|::|.||...||.||:||              ....:|    |:|:|.|......
Zfish    51 -LKALTYSILKKIKEKQLEVLLQAVESR--------------GGARSP----CLLLPGKADARLG 96

  Fly   281 PH-----VTASRLFFWRELWNAKELKRLPTCPAARDCIY-------MCCNPLHWFRILHQPETES 333
            .|     :...::|.|.:|.::.|||||..|.:     |       :||||.|..|:.   |.||
Zfish    97 QHSYPLPLLLYKVFRWPDLRHSSELKRLSCCES-----YGKINPELVCCNPHHMSRLC---ELES 153

  Fly   334 PTPPYQR--SKMLRLKDADFEEDSQNDAKSAALSTWSAESTSISNIYKPALYESVTTDGKDHNIN 396
            |.|||.|  :..|:..|:.....:..:....|.|.....|.|:      ||.|.    |:..:
Zfish   154 PPPPYSRYPTDFLKPPDSPGSVPASTETGGTAYSAPMGFSDSL------ALQER----GEQPH-- 206

  Fly   397 SQVWCQIAYWEMAHRVGEFFHAKTNAVNIYTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTV 461
               ||.:||||...|||..:..:..:::|:.|   ..:....||..|  |......:|...|..:
Zfish   207 ---WCVVAYWEEKTRVGRLYSVQEPSLDIFYD---LPQGTGFCLGQL--ASENKSQLVQMVRAKI 263

  Fly   462 GLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLDR----VCKVMPGYCLKAFETNRAELLSMRD 522
            |.|:.||.|...||:|||....||:.|.|| :|.|.    |.||.||:.:|||:..:|..|...:
Zfish   264 GYGIQLSREADGVWVYNRSCYPIFIKSATL-DNPDSRTLLVHKVFPGFSIKAFDFEKAGSLQRPN 327

  Fly   523 HGHHPMGPVDYFSIKISFGKGWGRDYKRQDIMGCPCWLEVHFSH 566
            .......|...|:::|||.||||:.|.||.|..|||||||.|::
Zfish   328 DHEFSQQPRTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNN 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	36/143 (25%)
		MH2_I-SMAD	400..565	CDD:199821	64/168 (38%)
smad7	NP_778257.2	MH1_SMAD_7	36..152	CDD:199818	37/145 (26%)
		MH2_SMAD_7	200..370	CDD:199825	66/184 (36%)