DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dad and Smox

DIOPT Version :9

Sequence 1:	NP_001369021.1	Gene:	Dad / 42059	FlyBaseID:	FBgn0020493	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001285006.1	Gene:	Smox / 31738	FlyBaseID:	FBgn0025800	Length:	486	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	116/473 - (24%)
Similarity:	182/473 - (38%)	Gaps:	157/473 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 GKRFREDFEALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIP-CKTQT 277
            ||...:..:.|:|::|:                  .:|.:.:|...:|.....:|:.:| .|...
  Fly    26 GKWSEKAVKNLVKKIKK------------------NSQLEELERAISTQNCQTRCVTVPRSKPAP 72

  Fly   278 VWE------PHVTASRLFFWRELWNAKELKRLPTCPAA----RDCIYMCCNPLHWFRI---LHQP 329
            ..|      |||...||:.|.:|.:..|||.|..|..|    ::.|  |.||.|:.:|   :..|
  Fly    73 AGEHLRKGLPHVIYCRLWRWPDLQSQNELKPLDHCEYAFHLRKEEI--CINPYHYKKIELSILVP 135

  Fly   330 ETESPTPPYQRSKMLRLKDA--DFEEDSQ----------NDA--KSAAL---------------- 364
            :: .||||          |:  |:..|:.          |.|  :||:|
  Fly   136 KS-LPTPP----------DSIVDYPLDNHTHQIPNNTDYNAAIIRSASLSPPQYMELGGAGPVSV 189

  Fly   365 ------------------STWSAESTSISNIYK-------------------------------P 380
                              |:.|:.|:|.::.|:                               |
  Fly   190 SSSASSTPATAAGGGGGPSSSSSSSSSAASAYQQQQQQLSFGQNMDSQSSVLSVGSSIPNTGTPP 254

  Fly   381 ALYESVTTDGKDHNINSQV-------------------WCQIAYWEMAHRVGEFFHAKTNAVNI- 425
            ..|.|...|..|.|.|..:                   ||.|:|:|:..||||.|||...::.:
  Fly   255 PGYMSEDGDPIDPNDNMNMSRLTPPADAAPVMYHEPAFWCSISYYELNTRVGETFHASQPSITVD 319

  Fly   426 -YTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDSP 489
             :||   .|..:..||..|:....  :.||.:.|..:|.||.|....|:|:.....:::|||.||
  Fly   320 GFTD---PSNSERFCLGLLSNVNR--NEVVEQTRRHIGKGVRLYYIGGEVFAECLSDSSIFVQSP 379

  Fly   490 TLSENLD----RVCKVMPGYCLKAFETNR-AELLSMR-DHGHHPMGPVDYF-SIKISFGKGWGRD 547
            ..::...    .|||:.||..||.|.... |.|||.. ..|...:..:... :|::||.||||.:
  Fly   380 NCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAE 444

  Fly   548 YKRQDIMGCPCWLEVHFS 565
            |:||.:...|||:|:|.:
  Fly   445 YRRQTVTSTPCWIELHLN 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	31/128 (24%)
Dad	NP_001369021.1	MH2_I-SMAD	400..565	CDD:199821	60/173 (35%)
Smox	NP_001285006.1	MH1_R-SMAD	7..130	CDD:199812	31/123 (25%)
Smox	NP_001285006.1	MH2_SMAD_2_3	285..475	CDD:199826	60/183 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444270
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13703
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840