Protein Alignment Dad and smad2

DIOPT Version :9

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001276944.1
• Gene: smad2 / 30639
• ZFINID: ZDB-GENE-990603-7
• Length: 468
• Species: Danio rerio
• Alignment Length: 500
• Identity: 118/500 - (23%)
• Similarity: 180/500 - (36%)
• Gaps: 157/500 - (31%)

  Fly   167 MISATTFTTMFRKCCGGATESTSGSTLTIPVSTSRATAHPPQTQAQNGKRFREDFEALMKQLKRK 231
            |.|...||....|...|..:|.|||:         ......:...|..|...:..::|:|:||
Zfish     1 MSSILPFTPPVVKRLLGWKKSASGSS---------GAGGGGEQNGQEEKWCEKAVKSLVKKLK-- 54

  Fly   232 QRNELLLAVKSRLDPPTKT-QRDVVEPTTTTAPTYLQCILIPCKTQTVWE--------------- 280
                             || |.|.:|...||.....:|:.||.....:|.
Zfish    55 -----------------KTGQLDELEKAITTQNRNTKCVTIPSNCSEIWGLSTPNTIEQWDTSGL 102

  Fly   281 ----------------------PHVTASRLFFWRELWNAKELKRLPTCPAA----RDCIYMCCNP 319
                                  |||...||:.|.:|.:..||:.:.||..|    :|  .:|.||
Zfish   103 YSYPDQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAIETCEYAFNLKKD--EVCVNP 165

  Fly   320 LHWFRI---------------------------------------LHQPET---ESPTPPYQRSK 342
            .|:.|:                                       :..|..   |:|.|.|..
Zfish   166 YHYQRVETPVLPPVLVPRHTEILTELPPLDDYTNSIPENTNFPTGIEPPNNYIPETPPPGYIS-- 228

  Fly   343 MLRLKDADFEEDSQNDAKSAALSTWSAESTSISNIYKPALYESVTTDGKDHNINSQ--------V 399
                :|.:..:...|.    ::.|.|           ||.....|....:|.::.|        .
Zfish   229 ----EDGEASDQQMNQ----SMDTGS-----------PAELSPSTLSPVNHGMDLQPVTYSEPAF 274

  Fly   400 WCQIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVG 462
            ||.|||:|:..||||.|||...::.:  :||   .|..:..||..|:....  ::.|...|..:|
Zfish   275 WCSIAYYELNQRVGETFHASQPSLTVDGFTD---PSNSERFCLGLLSNVNR--NATVEMTRRHIG 334

  Fly   463 LGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLD----RVCKVMPGYCLKAFETNR-AELLSMR- 521
            .||.|....|:|:.....::.|||.||..::...    .|||:.||..||.|.... |.||:..
Zfish   335 RGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSV 399

  Fly   522 DHGHHPMGPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFS 565
            :.|...:..:... :|::||.||||.:|:||.:...|||:|:|.:
Zfish   400 NQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLN 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	35/212 (17%)
		MH2_I-SMAD	400..565	CDD:199821	59/173 (34%)
smad2	NP_001276944.1	MH1_SMAD_2_3	8..173	CDD:199815	42/194 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	224..254		8/50 (16%)
		MH2_SMAD_2_3	267..457	CDD:199826	59/182 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810