DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dad and Smad2

DIOPT Version :9

Sequence 1:	NP_001369021.1	Gene:	Dad / 42059	FlyBaseID:	FBgn0020493	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001264379.1	Gene:	Smad2 / 29357	RGDID:	3031	Length:	467	Species:	Rattus norvegicus

Alignment Length:	510	Identity:	118/510 - (23%)
Similarity:	186/510 - (36%)	Gaps:	182/510 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 PVDRRMISATTFTTMFRKCCGGATESTSGSTLTIPVSTSRATAHPPQTQAQNG---KRFREDFEA 223
            ||.:|::.       ::|..||:..:..|.                    |||   |...:..::
  Rat    10 PVVKRLLG-------WKKSAGGSGGAGGGE--------------------QNGQEEKWCEKAVKS 47

  Fly   224 LMKQLKRKQRNELLLAVKSRLDPPTKTQR-DVVEPTTTTAPTYLQCILIPCKTQTVWE------- 280
            |:|:||                   ||.| |.:|...||.....:|:.||.....:|.
  Rat    48 LVKKLK-------------------KTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTANTV 93

  Fly   281 ------------------------------PHVTASRLFFWRELWNAKELKRLPTCPAA----RD 311
                                          |||...||:.|.:|.:..|||.:..|..|    :|
  Rat    94 DQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFSLKKD 158

  Fly   312 CIYMCCNPLHWFRI--------------------------LH------------QPET----ESP 334
              .:|.||.|:.|:                          .|            :|::    |:|
  Rat   159 --EVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETP 221

  Fly   335 TPPYQRSKMLRLKDADFEEDSQNDAK--SAALSTWSAESTSISNIYKPALYESVTTDGKDHNINS 397
            .|.|            ..||.:...:  :.::.|.|           ||.....|....:|:::.
  Rat   222 PPGY------------ISEDGETSDQQLNQSMDTGS-----------PAELSPTTLSPVNHSLDL 263

  Fly   398 Q--------VWCQIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCLRDLTPAGNQIHS 452
            |        .||.|||:|:..||||.|||...::.:  :||   .|..:..||..|:....  ::
  Rat   264 QPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTD---PSNSERFCLGLLSNVNR--NA 323

  Fly   453 VVPKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLD----RVCKVMPGYCLKAFETN 513
            .|...|..:|.||.|....|:|:.....::.|||.||..::...    .|||:.||..||.|...
  Rat   324 TVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQ 388

  Fly   514 R-AELLSMR-DHGHHPMGPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFS 565
            . |.||:.. :.|...:..:... :|::||.||||.:|:||.:...|||:|:|.:
  Rat   389 EFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLN 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	38/214 (18%)
Dad	NP_001369021.1	MH2_I-SMAD	400..565	CDD:199821	59/173 (34%)
Smad2	NP_001264379.1	MH1	8..172	CDD:412134	44/209 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..251		11/66 (17%)
		PY-motif. /evidence=ECO:0000250	221..225		2/3 (67%)
		MH2_SMAD_2_3	266..456	CDD:199826	59/183 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810