DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dad and daf-14

DIOPT Version :9

Sequence 1:	NP_001369021.1	Gene:	Dad / 42059	FlyBaseID:	FBgn0020493	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001255475.1	Gene:	daf-14 / 177908	WormBaseID:	WBGene00000910	Length:	331	Species:	Caenorhabditis elegans

Alignment Length:	256	Identity:	63/256 - (24%)
Similarity:	109/256 - (42%)	Gaps:	56/256 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 LKDADFEE---------DSQND-------AKSAALSTWSAESTSISNIYKPALYESVTTDGKDHN 394
            |:||...:         |..||       :..::|...:.|...:.  .:|...|.:..:.| :.
Worm    67 LEDAPMPDCYNVPSTSTDENNDPFPFSNISSQSSLKPKTPEKAVVE--VRPTGNEMLDPEPK-YP 128

  Fly   395 INSQVWCQIAYWEMAHRVGEFFHAKTNAVNIYTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARH 459
            ...:.||.|.|:|:..|:|:.|.||...:.|  ||  |:.....|...||...:..:|...:.|:
Worm   129 KEEKPWCTIFYYELTVRLGKAFEAKVPTITI--DG--ATGASDECRMSLTSQPSSRNSKSSQIRN 189

  Fly   460 TVGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLDRVCKV------------MPGYCLKAFET 512
            |||.|:.|:.|||::|:....:..:||..|.|::.|::..|.            |..:..:.||.
Worm   190 TVGAGIQLAYENGELWLTVLTDQIVFVQCPFLNQTLNKPLKYVFRLQNKGDQKRMKIFDKEQFEQ 254

  Fly   513 NRAELLSMRDHGHHPMGPVD-----------YFSIKISFGKGWGRDYKRQDIMGCPCWLEV 562
            .:...|          ||:.           :.:|::||.||:|..|.|..::..|||:|:
Worm   255 EKTLAL----------GPLTEKEVADERMRIFSNIRVSFCKGFGETYSRLKVVNLPCWIEI 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813
Dad	NP_001369021.1	MH2_I-SMAD	400..565	CDD:199821	52/186 (28%)
daf-14	NP_001255475.1	DWB	133..308	CDD:197770	52/187 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6357
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860