Protein Alignment Dad and sma-3

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_498493.1
• Gene: sma-3 / 175955
• WormBaseID: WBGene00004857
• Length: 393
• Species: Caenorhabditis elegans
• Alignment Length: 443
• Identity: 110/443 - (24%)
• Similarity: 180/443 - (40%)
• Gaps: 118/443 - (26%)

  Fly   205 HPPQTQAQNGKRFRED--------FEALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTT 261
            |.|..:...|.:..||        .|||:|:||:|...             ..|..|
 Worm     8 HGPAVKKLLGWKIGEDEEKWCEKAVEALVKKLKKKNNG-------------CGTLED-------- 51

  Fly   262 APTYLQCILI-PCKTQ---TVWE--------------PHVTASRLFFWRELWNAKELKRLPTC-- 306
                |:|:|. ||...   |:.:              |||...|::.|.::.:..||:.:.||
 Worm    52 ----LECVLANPCTNSRCITIAKSLDGRLQVSHKKGLPHVIYCRVWRWPDISSPHELRSIDTCSY 112

  Fly   307 --PAARDCIYMCCNPLHWFRILHQPE---TESPTP-PYQRSKMLRLKDADFEEDSQNDA-KSAAL 364
              .::...:|:|.||.|:.| |.:|:   :..|:| |.               .|.|.. :|:..
 Worm   113 PYESSSKTMYICINPYHYQR-LSRPQGLNSSMPSPQPI---------------SSPNTIWQSSGS 161

  Fly   365 STWSAESTSISNIYKPALYESVTTDGKDHNINS--------QVWCQIAYWEMAHRVGEFFHAKTN 421
            ||.|..|:...:::        :.||.:..::.        :.|.||.|:|:..||||.|  |..
 Worm   162 STASCASSPSPSVF--------SEDGGEVQVHQRPPPFRHPKSWAQITYFELNSRVGEVF--KLV 216

  Fly   422 AVNIYTDGIV--ASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLENGD----VWIYNRG 480
            .::|..||..  ::....:||..||....  :..:...|..:|.|:  .|:|.:    :.|.|..
 Worm   217 NLSITVDGYTNPSNSNTRICLGQLTNVNR--NGTIENTRMHIGKGI--QLDNKEDQMHIMITNNS 277

  Fly   481 NTTIFVDSPT----LSENLDRVCKVMPGYCLKAFETNRAELLSMRDHGHHPMGPVDYFS----IK 537
            :..:||.|..    ::..|.:||::.|...|..||.|.  ...|.:...:....::..|    |:
 Worm   278 DMPVFVQSKNTNLMMNMPLVKVCRIPPHSQLCVFEFNL--FFQMLEQSCNDSDGLNELSKHCFIR 340

  Fly   538 ISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQYLMLARSAGPHSASQHLVEP 590
            |||.||||.||.|||:...|||||:.. ::. .|:.......|.:   :|:||
 Worm   341 ISFVKGWGEDYPRQDVTSTPCWLELRL-NVPLAYIDQKMKQTPRT---NLMEP 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	36/153 (24%)
		MH2_I-SMAD	400..565	CDD:199821	56/178 (31%)
sma-3	NP_498493.1	MH1	10..133	CDD:469592	34/148 (23%)
		MH2_R-SMAD	197..379	CDD:199820	57/190 (30%)