DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dad and Smad7

DIOPT Version :9

Sequence 1:	NP_001369021.1	Gene:	Dad / 42059	FlyBaseID:	FBgn0020493	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001036125.1	Gene:	Smad7 / 17131	MGIID:	1100518	Length:	426	Species:	Mus musculus

Alignment Length:	424	Identity:	131/424 - (30%)
Similarity:	186/424 - (43%)	Gaps:	98/424 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 CCGGATESTSGSTLTIPVSTSRATAHPPQTQAQNGKRFREDFEAL----MKQLKRKQRNELLLAV 240
            |.|.|.....|          ....|||.:.|........|.:||    :|:||.:|...||.||
Mouse    61 CLGKAVRGAKG----------HHHPHPPTSGAGAAGGAEADLKALTHSVLKKLKERQLELLLQAV 115

  Fly   241 KSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWEPHVTAS-----------------RL 288
            :||             ..|.||     |:|:|.:......|...||                 ::
Mouse   116 ESR-------------GGTRTA-----CLLLPGRLDCRLGPGAPASAQPAQPPSSYSLPLLLCKV 162

  Fly   289 FFWRELWNAKELKRLPTCPAARDCIY-------MCCNPLHWFRILHQPETESPTPPYQRSKMLRL 346
            |.|.:|.::.|:|||..|.:     |       :||||.|..|:.   |.|||.|||.|..|
Mouse   163 FRWPDLRHSSEVKRLCCCES-----YGKINPELVCCNPHHLSRLC---ELESPPPPYSRYPM--- 216

  Fly   347 KDADFEEDSQN--DAKSAALSTWSAESTSISNIYKPALYES---VTTDGKDHNINSQVWCQIAYW 406
               ||.:.:..  ||..:     |||:...:.:....|.:|   :....:.|      ||.:|||
Mouse   217 ---DFLKPTAGCPDAVPS-----SAETGGTNYLAPGGLSDSQLLLEPGDRSH------WCVVAYW 267

  Fly   407 EMAHRVGEFFHAKTNAVNIYTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLEN 471
            |...|||..:..:..:::|:.|   ..:.:..||..|.  .:....:|.|.|..:|.|:.|:.|.
Mouse   268 EEKTRVGRLYCVQEPSLDIFYD---LPQGNGFCLGQLN--SDNKSQLVQKVRSKIGCGIQLTREV 327

  Fly   472 GDVWIYNRGNTTIFVDSPTLSENLDR----VCKVMPGYCLKAFETNRAELLSMRDHGHHPM-GPV 531
            ..||:|||.:..||:.|.|| :|.|.    |.||.||:.:|||:..:|..| .|.:.|..| .|.
Mouse   328 DGVWVYNRSSYPIFIKSATL-DNPDSRTLLVHKVFPGFSIKAFDYEKAYSL-QRPNDHEFMQQPW 390

  Fly   532 DYFSIKISFGKGWGRDYKRQDIMGCPCWLEVHFS 565
            ..|:::|||.||||:.|.||.|..|||||||.|:
Mouse   391 TGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFN 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	41/159 (26%)
Dad	NP_001369021.1	MH2_I-SMAD	400..565	CDD:199821	66/169 (39%)
Smad7	NP_001036125.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..42
		MH1_SMAD_7	60..205	CDD:199818	46/179 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..87		5/29 (17%)
		Important for interaction with SMURF2. /evidence=ECO:0000250	208..217		5/14 (36%)
		PY-motif. /evidence=ECO:0000250	208..211		1/2 (50%)
		MH2_SMAD_7	254..424	CDD:199825	67/182 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834115
Domainoid	1	1.000	126	1.000	Domainoid score	I5387
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	164	1.000	Inparanoid score	I4191
Isobase	1	0.950	-	0	Normalized mean entropy	S6357
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D193735at33208
OrthoFinder	1	1.000	-	-		FOG0003707
OrthoInspector	1	1.000	-	-		otm42561
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5077
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.840