Protein Alignment Dad and Smad6

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_032568.3
• Gene: Smad6 / 17130
• MGIID: 1336883
• Length: 495
• Species: Mus musculus
• Alignment Length: 552
• Identity: 164/552 - (29%)
• Similarity: 216/552 - (39%)
• Gaps: 119/552 - (21%)

  Fly    51 GYSCNEEDSLAMRQTPLPPYSSIACGMDCSSSNSSSCGQSLSLSQGQGHNNNNSHPYRRLPNHMD 115
            |...:|:.||..|..|.|....   |..||.|...|...                   |.|.  |
Mouse    29 GGGVDEDGSLGSRAEPAPRARE---GGGCSRSEVRSVAP-------------------RRPR--D 69

  Fly   116 VLPPPPSA-CDRCCTAPGYSCASSCDDMLIDGSDLDQDRSPDQGQVQPVDRRMISATTFTTMFRK 179
            .:.|..:| ..|.....|.....|.......||.||.......|.:...|...::
Mouse    70 AVGPRGAAIAGRRRRTGGLPRPVSESGAGAGGSPLDVAEPGGPGWLPESDCETVT---------- 124

  Fly   180 CCGGATESTSGSTLTIPVSTSRATAHP-----PQTQAQNGKRFREDFE--------------ALM 225
            ||..:....:|:        .|.:..|     |:.:...|.|.||...              :|:
Mouse   125 CCLFSERDAAGA--------PRDSGDPQARQSPEPEEGGGPRSREARSRLLLLEQELKTVTYSLL 181

  Fly   226 KQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVW----EPHVTAS 286
            |:||.:..:.||.||:||...|.                  .|:|:|.....:.    .|.:...
Mouse   182 KRLKERSLDTLLEAVESRGGVPG------------------GCVLVPRADLRLGGQPAPPQLLLG 228

  Fly   287 RLFFWRELWNAKELKRLPTC---PAARDCIYMCCNPLHWFRILHQPETESPTPPYQRSKMLRLKD 348
            |||.|.:|.:|.|||.|..|   .||.|...:||||.|:.|:.   ..|||.|||.     ||..
Mouse   229 RLFRWPDLQHAVELKPLCGCHSFTAAADGPTVCCNPYHFSRLC---GPESPPPPYS-----RLSP 285

  Fly   349 ADFEEDSQNDAKSAALSTWSAESTSISNIYKPALYE--SVTTDG--KDHNINSQVWCQIAYWEMA 409
            .|  :....|...:.||....|:|: |.|..|..:.  |::.|.  ..|      ||.:||||..
Mouse   286 PD--QYKPLDLSDSTLSYTETEATN-SLITAPGEFSDASMSPDATKPSH------WCSVAYWEHR 341

  Fly   410 HRVGEFFHAKTNAVNIYTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLENGDV 474
            .|||..:.....||:|:.|   ..:....||..|..  .|....|.:.|..:|.|:.||.|...|
Mouse   342 TRVGRLYAVYDQAVSIFYD---LPQGSGFCLGQLNL--EQRSESVRRTRSKIGFGILLSKEPDGV 401

  Fly   475 WIYNRGNTTIFVDSPTLSENLDR---VCKVMPGYCLKAFETNRAELLSMRDHGHHPMGPVDYFSI 536
            |.||||...|||:||||.....|   |.||.|||.:|.|:..|:.||...|..|   ||.|..|:
Mouse   402 WAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLLQHADAAH---GPYDPHSV 463

  Fly   537 KISFGKGWGRDYKRQDIMGCPCWLEVHFSHLR 568
            :|||.||||..|.||.|..||||||:..::.|
Mouse   464 RISFAKGWGPCYSRQFITSCPCWLEILLNNHR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	42/157 (27%)
		MH2_I-SMAD	400..565	CDD:199821	72/167 (43%)
Smad6	NP_032568.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..115		25/109 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	133..161		6/35 (17%)
		MH1_SMAD_6	161..274	CDD:199817	36/133 (27%)
		MH2_SMAD_6	323..493	CDD:199824	74/183 (40%)