DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dad and Smad6

DIOPT Version :9

Sequence 1:NP_001369021.1 Gene:Dad / 42059 FlyBaseID:FBgn0020493 Length:665 Species:Drosophila melanogaster
Sequence 2:NP_032568.3 Gene:Smad6 / 17130 MGIID:1336883 Length:495 Species:Mus musculus


Alignment Length:552 Identity:164/552 - (29%)
Similarity:216/552 - (39%) Gaps:119/552 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 GYSCNEEDSLAMRQTPLPPYSSIACGMDCSSSNSSSCGQSLSLSQGQGHNNNNSHPYRRLPNHMD 115
            |...:|:.||..|..|.|....   |..||.|...|...                   |.|.  |
Mouse    29 GGGVDEDGSLGSRAEPAPRARE---GGGCSRSEVRSVAP-------------------RRPR--D 69

  Fly   116 VLPPPPSA-CDRCCTAPGYSCASSCDDMLIDGSDLDQDRSPDQGQVQPVDRRMISATTFTTMFRK 179
            .:.|..:| ..|.....|.....|.......||.||.......|.:...|...::          
Mouse    70 AVGPRGAAIAGRRRRTGGLPRPVSESGAGAGGSPLDVAEPGGPGWLPESDCETVT---------- 124

  Fly   180 CCGGATESTSGSTLTIPVSTSRATAHP-----PQTQAQNGKRFREDFE--------------ALM 225
            ||..:....:|:        .|.:..|     |:.:...|.|.||...              :|:
Mouse   125 CCLFSERDAAGA--------PRDSGDPQARQSPEPEEGGGPRSREARSRLLLLEQELKTVTYSLL 181

  Fly   226 KQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVW----EPHVTAS 286
            |:||.:..:.||.||:||...|.                  .|:|:|.....:.    .|.:...
Mouse   182 KRLKERSLDTLLEAVESRGGVPG------------------GCVLVPRADLRLGGQPAPPQLLLG 228

  Fly   287 RLFFWRELWNAKELKRLPTC---PAARDCIYMCCNPLHWFRILHQPETESPTPPYQRSKMLRLKD 348
            |||.|.:|.:|.|||.|..|   .||.|...:||||.|:.|:.   ..|||.|||.     ||..
Mouse   229 RLFRWPDLQHAVELKPLCGCHSFTAAADGPTVCCNPYHFSRLC---GPESPPPPYS-----RLSP 285

  Fly   349 ADFEEDSQNDAKSAALSTWSAESTSISNIYKPALYE--SVTTDG--KDHNINSQVWCQIAYWEMA 409
            .|  :....|...:.||....|:|: |.|..|..:.  |::.|.  ..|      ||.:||||..
Mouse   286 PD--QYKPLDLSDSTLSYTETEATN-SLITAPGEFSDASMSPDATKPSH------WCSVAYWEHR 341

  Fly   410 HRVGEFFHAKTNAVNIYTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLENGDV 474
            .|||..:.....||:|:.|   ..:....||..|..  .|....|.:.|..:|.|:.||.|...|
Mouse   342 TRVGRLYAVYDQAVSIFYD---LPQGSGFCLGQLNL--EQRSESVRRTRSKIGFGILLSKEPDGV 401

  Fly   475 WIYNRGNTTIFVDSPTLSENLDR---VCKVMPGYCLKAFETNRAELLSMRDHGHHPMGPVDYFSI 536
            |.||||...|||:||||.....|   |.||.|||.:|.|:..|:.||...|..|   ||.|..|:
Mouse   402 WAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLLQHADAAH---GPYDPHSV 463

  Fly   537 KISFGKGWGRDYKRQDIMGCPCWLEVHFSHLR 568
            :|||.||||..|.||.|..||||||:..::.|
Mouse   464 RISFAKGWGPCYSRQFITSCPCWLEILLNNHR 495

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DadNP_001369021.1 MH1_SMAD_6_7 197..329 CDD:199813 42/157 (27%)
MH2_I-SMAD 400..565 CDD:199821 72/167 (43%)
Smad6NP_032568.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..115 25/109 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 133..161 6/35 (17%)
MH1_SMAD_6 161..274 CDD:199817 36/133 (27%)
MH2_SMAD_6 323..493 CDD:199824 74/183 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 126 1.000 Domainoid score I5387
eggNOG 1 0.900 - - E1_KOG3701
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 164 1.000 Inparanoid score I4191
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003707
OrthoInspector 1 1.000 - - otm42561
orthoMCL 1 0.900 - - OOG6_109794
Panther 1 1.100 - - LDO PTHR13703
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5077
SonicParanoid 1 1.000 - - X6247
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.850

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