Protein Alignment Dad and Smad5

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_032567.1
• Gene: Smad5 / 17129
• MGIID: 1328787
• Length: 465
• Species: Mus musculus
• Alignment Length: 464
• Identity: 113/464 - (24%)
• Similarity: 174/464 - (37%)
• Gaps: 147/464 - (31%)

  Fly   222 EALMKQLKRKQ--RNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWE---- 280
            :||:|:||:|:  ..||..|:.|...|.                   :|:.||.......:
Mouse    36 DALVKKLKKKKGAMEELEKALSSPGQPS-------------------KCVTIPRSLDGRLQVSHR 81

  Fly   281 ---PHVTASRLFFWRELWNAKELKRLPTC--PAARDCIYMCCNPLHWFRI--------------- 325
               |||...|::.|.:|.:..|||.|..|  |.......:|.||.|:.|:
Mouse    82 KGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNE 146

  Fly   326 ------------------------------LHQPET-------ESPTPP------YQRSKMLRLK 347
                                          .|||..       .||.||      |..|......
Mouse   147 FNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNAPFPLSPNSPYPPSPASSTYPNSPASSGP 211

  Fly   348 DADFE-------------------EDSQNDAKSAALSTWSAESTSISNIYKPALYESVTTDGKDH 393
            .:.|:                   ::||....|:.:...:..|.|..:: :|..||
Mouse   212 GSPFQLPADTPPPAYMPPDDQMAPDNSQPMDTSSNMIPQTMPSISSRDV-QPVAYE--------- 266

  Fly   394 NINSQVWCQIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCLRDLTPAGNQIHSVVPK 456
              ..:.||.|.|:|:.:||||.|||.:.:|.:  :||  .::.....||..|:....  :|.:..
Mouse   267 --EPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTD--PSNNKSRFCLGLLSNVNR--NSTIEN 325

  Fly   457 ARHTVGLGVTLSLENGDVWIYNRGNTTIFVDS----------PTLSENLDRVCKVMPGYCLKAFE 511
            .|..:|.||.|....|:|:.....:::|||.|          ||      .|||:.....||.|.
Mouse   326 TRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPT------TVCKIPSSCSLKIFN 384

  Fly   512 TNR-AELLSMR-DHGHHPMGPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQYL- 572
            ... |:||:.. :||...:..:... :|::||.||||.:|.|||:...|||:|:|. |.. |:|
Mouse   385 NQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL-HGPLQWLD 448

  Fly   573 -MLARSAGP 580
             :|.:...|
Mouse   449 KVLTQMGSP 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	32/162 (20%)
		MH2_I-SMAD	400..565	CDD:199821	59/179 (33%)
Smad5	NP_032567.1	MH1_SMAD_1_5_9	10..133	CDD:199814	31/115 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..251		13/87 (15%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	66/215 (31%)