Protein Alignment Dad and smad6a

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001019981.2
• Gene: smad6a / 116992
• ZFINID: ZDB-GENE-011015-1
• Length: 456
• Species: Danio rerio
• Alignment Length: 421
• Identity: 126/421 - (29%)
• Similarity: 188/421 - (44%)
• Gaps: 71/421 - (16%)

  Fly   182 GGATESTSGSTLT------IPVSTSR---------------ATAHPPQTQAQNGKRFREDFEALM 225
            |...:.:.|.|:|      :|.|.:|               .:....:|.|...:..::...|.:
Zfish    73 GPLNDGSEGRTVTCCLFKDLPRSKNRLACRVEHRNHNNYSSLSGRERKTGAVTEQELKKCTYAFL 137

  Fly   226 KQLKRKQRNELLLAVKSRLDPPT----KTQRDVVEPTTTTAPTYLQCILIPCKTQTVWEPHVTAS 286
            |:||.|..:.||.||:|:...|:    .:|.:|.......:|.||.|
Zfish   138 KKLKDKSLDVLLEAVESQGGMPSGCVLVSQTEVRIGGHLVSPQYLLC------------------ 184

  Fly   287 RLFFWRELWNAKELKRLPTCPA--ARDCIYMCCNPLHWFRILHQPETESPTPPYQRSKMLRLKDA 349
            |||.|.:|..:..||.|..|.:  |.|...:||||.|:.|:....:.::|.|||.....|
Zfish   185 RLFRWPDLRLSSLLKPLCHCQSFRAEDSQTLCCNPHHYSRLCGPVKDDTPPPPYSHLSPL----- 244

  Fly   350 DFEEDSQNDAKSAALSTWSAEST----SISNIYKPALYESVTTDGKDHNINSQVWCQIAYWEMAH 410
              .|....::....|.....|:|    .:|..|..|.. |.::..::|      ||.:||||:..
Zfish   245 --PEHKPLNSSLPMLPYIETEATRSAGGLSQDYSDASM-SPSSLAQNH------WCNVAYWELRT 300

  Fly   411 RVGEFFHAKTNAVNIYTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLENGDVW 475
            |||..:.....:::|:.|   ..:...:|| .|.|...:..| |.:.|..:|.|:.||.|...||
Zfish   301 RVGRLYPVHDASLSIFYD---LPQGTGLCL-GLLPLSPRSTS-VQRTRGKIGHGILLSKEPDGVW 360

  Fly   476 IYNRGNTTIFVDSPTLSEN--LD-RVCKVMPGYCLKAFETNRAELLSMRDHGHHPMGPVDYFSIK 537
            .|||....|||:||||..:  |. .|.:|||||.:|.|:..::..:....|..||.||.|..|::
Zfish   361 AYNRSQHPIFVNSPTLEHHPYLSLTVRRVMPGYSIKVFDYEKSCQMQPASHPVHPEGPYDPNSVR 425

  Fly   538 ISFGKGWGRDYKRQDIMGCPCWLEVHFSHLR 568
            |||.||||..|.||.|..||||||:..::.|
Zfish   426 ISFAKGWGPCYSRQFITSCPCWLEILLNNHR 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	38/152 (25%)
		MH2_I-SMAD	400..565	CDD:199821	68/167 (41%)
smad6a	NP_001019981.2	MH1_SMAD_6	118..229	CDD:199817	36/128 (28%)
		MH2	281..454	CDD:469593	70/183 (38%)