DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dad and smad7

DIOPT Version :9

Sequence 1:	NP_001369021.1	Gene:	Dad / 42059	FlyBaseID:	FBgn0020493	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	XP_004910394.1	Gene:	smad7 / 100486892	XenbaseID:	XB-GENE-486004	Length:	383	Species:	Xenopus tropicalis

Alignment Length:	409	Identity:	122/409 - (29%)
Similarity:	182/409 - (44%)	Gaps:	86/409 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 CCGGATESTSGSTL-TIPVSTSRATAHPPQTQAQNGKRFREDFEALMKQLKRKQRNELLLAVKSR 243
            |.|.:.....|..| ....:..:|.||                 :::|:||.||...||.||:.:
Frog    38 CLGKSANKVPGKALGGSEAAELKALAH-----------------SVLKKLKEKQLEGLLQAVECK 85

  Fly   244 LDPPTKTQRDVVEPTTTTAPTYLQCILIPCKT------QTVWEPHVTASRLFFWRELWNAKELKR 302
                          ....:|    |:|:|...      |..:...:...::|.|.:|.::.|:||
Frog    86 --------------GGARSP----CLLLPAAKLDSRLGQQPFSLPLLLCKVFRWPDLRHSSEVKR 132

  Fly   303 LPTCPA--ARDCIYMCCNPLHWFRILHQPETESPTPPYQRSKMLRLKDADFEEDSQNDAKSAALS 365
            |..|.:  ..:...:||||.|..|:.   |.|||.|||.|..|      ||.:.:.:...|...|
Frog   133 LSCCDSYGKNNPELVCCNPHHLSRLC---ELESPPPPYTRYPM------DFLKPTADSPDSVPSS 188

  Fly   366 TWSAESTSISNIYKPALYESVTTDGK--------DHNINSQVWCQIAYWEMAHRVGEFFHAKTNA 422
            |    .|..:|...|   |.::.|.:        .|      ||.:||||...|||..:..:..:
Frog   189 T----ETGGTNFLAP---EGLSADSQLLHETGDPSH------WCVVAYWEEKTRVGRLYSVQEPS 240

  Fly   423 VNIYTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLENGDVWIYNRGNTTIFVD 487
            ::|:.|   ..:.:..||..|.  .:....:|.|.|..:|.|:.|:.|...||:|||.:..||:.
Frog   241 LDIFYD---LPQGNGFCLGQLN--SDNKSQLVQKVRSKIGYGIQLTKEVDGVWVYNRSSYPIFIK 300

  Fly   488 SPTLSENLDR----VCKVMPGYCLKAFETNRAELLSMRDHGHHPM-GPVDYFSIKISFGKGWGRD 547
            |.|| :|.|.    |.||.||:.:|||:..:|..| .|.:.|..| .|...|:::|||.||||:.
Frog   301 SATL-DNPDSRTLLVHKVFPGFSIKAFDYEKAYSL-QRPNDHEFMQQPWTGFTVQISFVKGWGQC 363

  Fly   548 YKRQDIMGCPCWLEVHFSH 566
            |.||.|..|||||||.|::
Frog   364 YTRQFISSCPCWLEVIFNN 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	31/139 (22%)
Dad	NP_001369021.1	MH2_I-SMAD	400..565	CDD:199821	66/169 (39%)
smad7	XP_004910394.1	MH1_SMAD_7	36..163	CDD:199818	37/162 (23%)
smad7	XP_004910394.1	MH2_SMAD_7	211..381	CDD:199825	67/182 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5637
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D193735at33208
OrthoFinder	1	1.000	-	-		FOG0003707
OrthoInspector	1	1.000	-	-		otm47666
Panther	1	1.100	-	-	O	PTHR13703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5077
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.050