Protein Alignment Dad and smad6

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: XP_004912726.1
• Gene: smad6 / 100038072
• XenbaseID: XB-GENE-481307
• Length: 357
• Species: Xenopus tropicalis
• Alignment Length: 400
• Identity: 133/400 - (33%)
• Similarity: 175/400 - (43%)
• Gaps: 89/400 - (22%)

  Fly   180 CCGGATESTSGSTLTIPVSTSRATAHPPQTQAQNGKRFREDFEALMKQLKRKQRNELLLAVKSRL 244
            || |.:|..|||               |:.:|.        ..|::|:||.:....||.||:||.
 Frog    26 CC-GLSEQPSGS---------------PELRAA--------ASAILKRLKEQALCALLEAVESRG 66

  Fly   245 DPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWEPHVTASRLFFWRELWNAKELKRLPTCPAA 309
            ..|.                  .|:   |.|:....||:...|||.|.||.:..:||.|..|..|
 Frog    67 AAPG------------------GCV---CVTRHGPPPHLLLCRLFRWPELQHPGQLKALCGCQGA 110

  Fly   310 --RDCIYMCCNPLHWFRILHQPETESPTPPYQR------SKMLRLKDADFEEDSQNDAKSAALST 366
              .:...:||||.|:.|:.   ..|||.|||.|      .|.|.|.|:..|.::.|   |..::.
 Frog   111 GGSENNSVCCNPYHYSRVC---GPESPPPPYSRLSPKIEQKPLDLSDSYTEMEASN---SLCITA 169

  Fly   367 WSAESTSISNIYKPALYESVTTDGKDHNINSQVWCQIAYWEMAHRVGEFFHAKTNAVNIYTDGIV 431
            .....||.||   .:|...::..|.        ||.:||||...|||..:.....:|:|:.|
 Frog   170 GDISGTSASN---TSLSPDMSKQGH--------WCSVAYWEHRTRVGRLYAVCQPSVSIFYD--- 220

  Fly   432 ASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLD 496
            ..:....||..|......  ....:.|..:|||:.||.|...||.|||.:..|||:||||.....
 Frog   221 LPQGSGFCLGQLNLENRS--EAAARTRGKIGLGIVLSREADGVWAYNRSDHPIFVNSPTLDAPAC 283

  Fly   497 R---VCKVMPGYCLKAFETNRAELLSMRDHGHHPM------GPVDYFSIKISFGKGWGRDYKRQD 552
            |   |.||||||.||.|:..::.:|.     |||.      ||.|..|::|||.||||..|.||.
 Frog   284 RPLVVRKVMPGYSLKVFDYKKSCVLR-----HHPTPPEHTDGPYDPHSVRISFAKGWGPCYSRQM 343

  Fly   553 IMGCPCWLEV 562
            |..|||||||
 Frog   344 ITSCPCWLEV 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	35/133 (26%)
		MH2_I-SMAD	400..565	CDD:199821	70/171 (41%)
smad6	XP_004912726.1	MH1_SMAD_6	27..132	CDD:199817	41/152 (27%)
		MH2_SMAD_6	183..357	CDD:199824	71/188 (38%)