DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patr-1 and Patl2

DIOPT Version :9

Sequence 1:	NP_001287369.1	Gene:	Patr-1 / 42058	FlyBaseID:	FBgn0266053	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_080527.2	Gene:	Patl2 / 67578	MGIID:	1914828	Length:	529	Species:	Mus musculus

Alignment Length:	620	Identity:	135/620 - (21%)
Similarity:	241/620 - (38%)	Gaps:	186/620 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 PSSQQQLNGIGGNRVPPGFIYPQGLPGNIPQLPQHPLMQQHMPHNFPLPGGNQRPLPNPQALPTA 377
            |..:::..|:|...:...|...|     :||  |..|   |..|...:.|.        ..:.:|
Mouse    49 PEVKEEGCGLGDPAIVSAFQNTQ-----VPQ--QRGL---HSSHRVKVSGA--------LGMSSA 95

  Fly   378 LNNFAMHPSFNAMRAAGIHPGAFMQPPHPHQMLPPRMPPHPLQAATSLLGQQPPNSMYNMFNMRL 442
            ..:|.....|....:...|.|.....|.|.....|..|             .||       .:.|
Mouse    96 SLHFMWQSVFPRASSPAHHFGPQQPSPDPFLFYSPLTP-------------WPP-------KLSL 140

  Fly   443 VQEIQQNHPLLQQAAVVRQMQQSRAGSVASDRQRSQAQQQQQGRRPDGTGNYPLEEYDEYANLMS 507
            ...:.|.||..||  :::|.|:.|..  .|...||...|:...|.|..:        |.|||||:
Mouse   141 PSHLTQLHPQHQQ--ILQQQQRWRRR--RSPTARSVPAQKPWSREPAAS--------DAYANLMT 193

  Fly   508 TRDKHWLIGIQLSQLNTDTPYIDDYYYTVFRERKAQQNGQMRNSQAHKDNQLNHPLTQPRGHAQL 572
            .::|.|:|.:|:.||.::.|.:|||||..:.::       :...||.|:
Mouse   194 RKEKDWVIRVQMVQLQSENPRLDDYYYQKYYQK-------LEKRQADKE---------------- 235

  Fly   573 ILVQLGNKNGTRNGHGRERRNSENTNSTSGNTNNGSGGNNNNLTGYIFSP------LKFENSLGK 631
               .||.|  ||         :|:...               :|.||..|      ::.|.|||:
Mouse   236 ---LLGQK--TR---------AESLKL---------------VTPYIQKPEVYESVVRIEGSLGQ 271

  Fly   632 LQYGSVTAPRKIIDADIMSGESNAAAEANATSSSKSSTPLPTSASHDVNPSSMRKSRHILLLIET 696
            :...:..:||:.||| :..|                      :...|...:|.::.| :|..||.
Mouse   272 VAVSTCFSPRRAIDA-VSHG----------------------TQEQDTGAASSQRLR-VLSQIEK 312

  Fly   697 LYRYLLKLEDLES---PEVMATIELKKKKEAERIAALEQLEMANKTPEERAAEAANPQTMNPQLK 758
            ::..|||:|:.::   |::..|        .|:.:.:|:|..|.||.|:...|.
Mouse   313 MFLQLLKIEEGQNDGLPQLYHT--------REQSSQVEKLFQALKTQEQNNLEE----------- 358

  Fly   759 NKFNYEVETKAALVNKLKAGLAFDKVIAMMNVRKGKILIRRIMPFI-ADQSIRWVVWSGVFCSLQ 822
                                 |.|.::.:::|||||:|:.|::||: .||::..:::  :...|.
Mouse   359 ---------------------AADNLLQVLSVRKGKVLVARLLPFLPPDQAVSLLLY--ITYHLP 400

  Fly   823 TVVKKDKDDVEGVLYALYPEFKKHVNKATFELLVSISSAITL-----NDKKLAGIFCSRFGILSL 882
            .::::|..| :| |:.|:....|:::..||..|:.....:.|     :::.::.:..::|||..|
Mouse   401 LLIQRDMAD-QG-LHMLFKPLGKYISHLTFHQLLHAMQGLMLLSPGSSERPVSVVLQNQFGISLL 463

  Fly   883 VALILRAEEIYVSRTDATLSEENRQKWREFLAQVA 917
            .||:...|:: ||...:..|..:...|.:.:..:|
Mouse   464 YALLSHGEQL-VSLDPSLRSSSDCATWTDLVILIA 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patr-1	NP_001287369.1	PAT1	<334..>589	CDD:286811	60/254 (24%)
Patl2	NP_080527.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..183		9/33 (27%)
Patl2	NP_080527.2	PAT1	<265..>399	CDD:370676	43/199 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837762
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4592
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I4403
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002413
OrthoInspector	1	1.000	-	-		otm42842
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21551
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R889
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.880