DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patr-1 and patl2

DIOPT Version :9

Sequence 1:	NP_001287369.1	Gene:	Patr-1 / 42058	FlyBaseID:	FBgn0266053	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_683261.4	Gene:	patl2 / 556271	ZFINID:	ZDB-GENE-121214-350	Length:	714	Species:	Danio rerio

Alignment Length:	864	Identity:	172/864 - (19%)
Similarity:	286/864 - (33%)	Gaps:	324/864 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 EDIERNMIIQQAIPKQ---------------------QQQSQQQAERKMFDDFSLGNRQQV---- 252
            ||.|:|   ::.||..                     |:.:::..|..::::.:.|..:.|
Zfish     5 EDPEKN---REPIPDAVWPENGDQWSDKGEDDECGLLQEMAEEDEEIDLYNEETFGLDEAVNGDT 66

  Fly   253 ----PTPTMLQQQMLQQQHHQKQQSQQQPPQQAQHKVPPGFLGTPHT----SPPRPNLGFPGPEL 309
                ||..:|    |........||...||......:||   .:|.|    .||||.     |..
Zfish    67 PDIDPTDLLL----LSSDSSPTPQSSHPPPPPPPPPLPP---KSPFTYSTHCPPRPE-----PHS 119

  Fly   310 LP-TPSSQQQLNGIGG------------------------------------------------- 324
            .| ||:.:.| .|.||
Zfish   120 WPHTPTGRSQ-RGRGGRGQLFDDPAVVKTVKGRPSLKSIDSAIVDCSLSTYWEDLNSNSWMVAPL 183

  Fly   325 -------------------------NRVPPGFIYPQGLPGNIPQLPQHPLMQQHMPHNFPLPGG- 363
                                     .||||  :.|..|.      |..|..........|..|.
Zfish   184 KSSRSPAQTILQDQAIVGVIDRSAHGRVPP--VSPNFLS------PMRPFSTSRGRRGQPFVGSF 240

  Fly   364 NQR-------------PLPNPQALPTALNNFAMHPSFNAMRAAGIHPGAFMQPPHPHQMLPPRMP 415
            |||             |:..||.|      |:....:|       .||.||.|..|  .|...||
Zfish   241 NQRCHYQAQKTPMAPCPVFRPQRL------FSPQQQYN-------QPGGFMSPSRP--PLSTSMP 290

  Fly   416 PHPLQAATSLLGQQPPNSMYNMFNMRLVQEIQQNHPLLQQAAVVRQMQQSRA-GSVASDRQRSQA 479
            ..|                 .:.::|...:..:..|....:|.:  ||..|| |.|.....:.:.
Zfish   291 RTP-----------------KLMHLRFGTDSPRPAPFYSPSASI--MQGLRAPGPVVQFHPQHKR 336

  Fly   480 QQQQQGRRPDGTGNYPLEEYDEYANLMSTRDKHWLIGIQLSQLNTDTPYIDDYYYTVFRERKAQQ 544
            ...|:..||.   ..|| .:|.|:.:||.::|.|:|.:|:.||.::.|::|||||..:.:|
Zfish   337 LLSQRQPRPH---KKPL-SWDPYSQIMSDKEKEWIIRLQMIQLQSENPHLDDYYYQEYYQR---- 393

  Fly   545 NGQMRNSQAHKDNQLNHPLTQPRGHAQLILVQLGNKNGTRNGHGRERRNSENTNSTSGNTNNGSG 609
               |....|.::                              :..:|...|....|
Zfish   394 ---METKLAEEE------------------------------YVGDRTKKEPPKLT--------- 416

  Fly   610 GNNNNLTGYIFSPLKF------ENSLGKLQYGSVTAPRKIIDADIMSGESNAAAEANATSSSKSS 668
                  |.|:...:.:      |.|||::...:..:||:.|||
Zfish   417 ------TPYVSKNVSYIPVVHIEGSLGQVAVSTCFSPRRAIDA---------------------- 453

  Fly   669 TPLPTSASHDVNPSSMRKSRHILLLIETLYRYLLKLEDLESPEVMATIELKKKKEAERIAALEQL 733
               ..:::||.:..:.::...:|..||.||..||::|:.|  :|..|:  ..|:|..|:.
Zfish   454 ---VHASTHDEHKDTRQQRLEVLSTIEKLYLILLEVEEAE--KVKTTV--SDKEEESRLM----- 506

  Fly   734 EMANKTPEERAAEAANPQTMNPQLKNKFNYEVETKAALVNKLKAGLAFDKVIAMMNVRKGKILIR 798
                             |.|..:::..:|   |.:.   ..|.:|   ::.::.:.|.|||.|:.
Zfish   507 -----------------QNMKRKVEQLYN---ELRC---TNLDSG---EEFLSCLLVSKGKRLVA 545

  Fly   799 RIMPFIADQSIRWVVWSGVFCSLQTVVKKDKDDVEGVLYALYPEFKKHVNKATFELLVSISSAIT 863
            |::||::..|...:: |.|...|..::.:|.|:   .|..|||..:..:|...|..|:.|....|
Zfish   546 RLLPFLSHDSALHIL-STVTKHLPVLMSRDTDE---ALPILYPSLRAVINGLVFSQLIRILKEFT 606

  Fly   864 L-----NDKKLAGIFCSRFGILSLVALILRAEEIYVSRTDATLSEENRQKWREFLAQVASCLNRT 923
            .     .|.:|.....::||:..|.||:.:.|.:..|......|..:.:.|.:.:..||..|::|
Zfish   607 ALLPDSQDTRLTLACQNKFGLSLLYALLSQGERLLSSDLPMEPSIGDFETWTDTVFHVARQLSQT 671

  Fly   924 IQNQTISAAIESDAIQPLM 942
                        ..::||:
Zfish   672 ------------SLVEPLL 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patr-1	NP_001287369.1	PAT1	<334..>589	CDD:286811	58/269 (22%)
patl2	XP_683261.4	PAT1	<247..>570	CDD:286811	97/473 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581506
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4592
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4852
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D404416at33208
OrthoFinder	1	1.000	-	-		FOG0002413
OrthoInspector	1	1.000	-	-		otm24517
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21551
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R889
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.890