DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patr-1 and Patl1

DIOPT Version :9

Sequence 1:	NP_001287369.1	Gene:	Patr-1 / 42058	FlyBaseID:	FBgn0266053	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_766223.2	Gene:	Patl1 / 225929	MGIID:	2147679	Length:	770	Species:	Mus musculus

Alignment Length:	1044	Identity:	237/1044 - (22%)
Similarity:	367/1044 - (35%)	Gaps:	370/1044 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DDSFFGFDTNLPDEDGGDGRIVEAEYDALNDETFGS-AINGDWEEAHETMVRLGGNGERVRKRPA 65
            :|:|.|    |.:||        .|.|..||:|||| |::.||:||||.:..|      ..|.|.
Mouse    16 EDAFQG----LGEED--------EEIDQFNDDTFGSGAVDDDWQEAHERLAEL------EEKLPV 62

  Fly    66 ESSGNTDFADQGNGAFLRHANPLSSAPSSSGSTPAPLNAPFRQSRHIGDSDLELNISSMKLDDMD 130
            .:...|     |||                                             :.|:||
Mouse    63 AADEQT-----GNG---------------------------------------------ERDEMD 77

  Fly   131 LSSFTTDSEAGGLSNRIKLDSGVWGSQPFPNNQHLFREP--MRSAFKPQQQQHQQHQPQQMKPPQ 193
            |.....::.|..||..:              .::...:|  ||:.     |.....|||    |.
Mouse    78 LLGDHEENLAERLSKMV--------------IENELEDPAIMRAV-----QTRPVLQPQ----PG 119

  Fly   194 EANANF------------ALNPQPFPKITTLEDIERNMIIQQAIPKQQQQSQQQAERKMFDDFSL 246
            ..|::.            .|..|..|.::.||         .|:|::..|..:       ||..|
Mouse   120 SLNSSIWDGSEVLRRIRGPLLAQEMPTVSVLE---------YALPQRPLQGPE-------DDRDL 168

  Fly   247 GNR-------------------------QQVPTPTMLQQQMLQQQHHQKQQSQQQPPQQAQHKVP 286
            ..|                         :|:..|:..||.:..:..|.:      ||...::..|
Mouse   169 SERALPRRSTSPIIGSPPVRAVPIGTPPKQMAVPSFNQQILCPKPVHVR------PPMPPRYPAP 227

  Fly   287 PGFLGTPHTSPPRPN---LGFPGPELLP---TPSSQQQLNGIGGNRVPPGFIYPQ---GLPGNIP 342
            .|...:|:.....||   ||.|.|..:|   :|..:.||  :||.::.||.:.|.   .:||.:
Mouse   228 YGERISPNQLCSVPNSSLLGHPFPPNVPPVLSPLQRAQL--LGGAQLQPGRMSPSQFARVPGFV- 289

  Fly   343 QLPQHPLMQQHMPHNFPLPGGNQRPLPN--PQALPTALNNFAMHPSFNAMRAAGIHPGAFMQPPH 405
                          ..||...|.:.|..  .|.||.|       |||.|..:|   |.....||.
Mouse   290 --------------GSPLAAMNPKLLQGRVGQMLPPA-------PSFRAFFSA---PPPATPPPQ 330

  Fly   406 PHQMLPPRMPPHPLQAATSLLGQQPPNSMYNMFNMRLVQEIQQNHPLLQQAAVVRQMQ---QSRA 467
            .|   ||...|| ||   :|..|.|      ||.........|:..||.|    ||:|   |.|.
Mouse   331 QH---PPGPGPH-LQ---NLRPQAP------MFRADTTHLHPQHRRLLHQ----RQLQSRNQHRN 378

  Fly   468 GSVASDRQRSQAQQQQQGRRPDGTGNYPLEEYDEYANLMSTRDKHWLIGIQLSQLNTDTPYIDDY 532
            .:...||...|:..|...|:            |.|||||..|:|.|:..||:.||.:..||:||:
Mouse   379 LNGTGDRGGHQSSHQDHLRK------------DPYANLMLQREKDWVSKIQMMQLQSTDPYLDDF 431

  Fly   533 YYTVFRERKAQQNGQMRNSQAHKDNQLNHPLTQPRGHAQLILVQLGNKNGTRNGHGRERRNSENT 597
            ||..:.|:       :....|.::.|.:.|   .:...:||..|:....
Mouse   432 YYQNYFEK-------LEKLSAAEEIQGDGP---KKERTKLITPQVAKLE---------------- 470

  Fly   598 NSTSGNTNNGSGGNNNNLTGYIFSPLKFENSLGKLQYGSVTAPRKIIDADIMSGESNAAAEANAT 662
                                :.:.|::||.|||||...||..|||:|||.:
Mouse   471 --------------------HAYQPVQFEGSLGKLTVSSVNNPRKMIDAVV-------------- 501

  Fly   663 SSSKSSTPLPTSASHDVNPSSMR---KSRHILLLIETLYRYLLKLEDLESPEVMATIELKKKKEA 724
                      ||.|.|......:   |.|..|::||..|..||.:||.|...:::.       |.
Mouse   502 ----------TSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSL-------EE 549

  Fly   725 ERIAALEQLE---------MANKTP-EERAAEAANPQTMNPQLKNKFNYEVETKAALVNKLKAGL 779
            ||.|.:::.:         :..|.| :||.::
Mouse   550 ERPALMDERKHKICSMYDNLRGKLPGQERPSD--------------------------------- 581

  Fly   780 AFDKVIAMMNVRKGKILIRRIMPFIADQSIRWVVWSGVFCSLQTVVKKD-KDDVEGVLYALYPEF 843
              |..:.:|.:||||.::.||:||::.:....::.: ...:|..::||| :|:|...|.:.:...
Mouse   582 --DHFVQIMCIRKGKRMVARILPFLSTEQAADILMA-TARNLPFLIKKDAQDEVLPCLLSPFSLL 643

  Fly   844 KKHVNKATFELLV-------SISSAITLNDKKLAGIFCSRFGILSLVALILRAEEIYVSRTDATL 901
            ..|:...|...|:       ..:||...::..|..:..::||:..|:.|:.|.|::..|  |..:
Mouse   644 LYHLPSVTVTSLLQQLMNLPQSASAPAPSNSHLTAVLQNKFGLSLLLILLSRGEDLQSS--DPAI 706

  Fly   902 SEENRQKWREFLAQVASCLNRTIQNQTISAAIESDAIQP--LMDHFERFKDLK----LDALLALI 960
            ......:|.|.:......|.|..|     ||:......|  |:..|.|:.|.:    |:..|.|:
Mouse   707 ESTQNNQWTEVMFMATRELLRIPQ-----AALAKPISIPTNLVSLFSRYVDRQKLNLLETKLQLV 766

  Fly   961 TEAR 964
            ...|
Mouse   767 QGIR 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patr-1	NP_001287369.1	PAT1	<334..>589	CDD:286811	71/262 (27%)
Patl1	NP_766223.2	Involved in nuclear foci localization. /evidence=ECO:0000250	1..397		124/537 (23%)
		Region A, interaction with DDX6/RCK. /evidence=ECO:0000250	1..84		32/135 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		14/37 (38%)
		ASF1_hist_chap	<8..104	CDD:304562	36/169 (21%)
		Region N, interaction with decapping machinery. /evidence=ECO:0000250	85..388		90/391 (23%)
		Nuclear export signal. /evidence=ECO:0000250	86..95		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..195		6/46 (13%)
		Involved in RNA-binding. /evidence=ECO:0000250	223..397		61/217 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..340		9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..396		5/19 (26%)
		Region H. /evidence=ECO:0000250	389..448		24/77 (31%)
		Involved in nuclear spleckles localization. /evidence=ECO:0000250	398..770		111/503 (22%)
		Region C. /evidence=ECO:0000250	449..770		90/433 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837761
Domainoid	1	1.000	111	1.000	Domainoid score	I6296
eggNOG	1	0.900	-	-		E1_KOG4592
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I4403
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D404416at33208
OrthoFinder	1	1.000	-	-		FOG0002413
OrthoInspector	1	1.000	-	-		otm42842
orthoMCL	1	0.900	-	-		OOG6_108520
Panther	1	1.100	-	-	LDO	PTHR21551
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R889
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.790