DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5220 and FTSJ3

DIOPT Version :9

Sequence 1:	NP_650590.1	Gene:	CG5220 / 42056	FlyBaseID:	FBgn0038471	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_060117.3	Gene:	FTSJ3 / 117246	HGNCID:	17136	Length:	847	Species:	Homo sapiens

Alignment Length:	302	Identity:	93/302 - (30%)
Similarity:	150/302 - (49%)	Gaps:	29/302 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GKTSKDKRDIYYRQAKDEGWRARSAFKLLHVDEAYGILNGVQRAVDLCAAPGSWSQVLSRKLYDT 66
            ||..|.:||.:|..||:.|:|:||||||:.::..:..|...:..:|||||||.|.||.::.:
Human     5 GKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQVAAKFM--- 66

  Fly    67 CETDDEKSAVKIIAVDLQAMAPIRGILQLQGDITKQSTAEAIIGHFGGNEKAQLVVCDGAPDVTG 131
                  ..:..|:.|||..:.|:..::.||.|||.:...:|:.... ...|..:|:.||||:|..
Human    67 ------PVSSLIVGVDLVPIKPLPNVVTLQQDITTERCRQALRKEL-KTWKVDVVLNDGAPNVGA 124

  Fly   132 VHEMDEYMQHQLLVAALSIATCVLETGGTFVAKIFKGNATSLLSSQMQIFFKKFDIYKPPSSRPS 196
            ....|.|.|..|.:.||.:|...|..||:|:.|:|:......|....|..|::....||.:||..
Human   125 SWVHDAYSQAHLTLMALRLACDFLARGGSFITKVFRSRDYQPLLWIFQQLFRRVQATKPQASRHE 189

  Fly   197 SIEAFVVCSDFCLPEGYIPQVINP--ARDDIRLLAQKTGSEVNRRLVP---FIACGDLNGLSDPE 256
            |.|.||||..|..|:....:..:|  |..::.:.| ||.:|:..:..|   ..|.|||....
Human   190 SAEIFVVCQGFLAPDKVDSKFFDPKFAFKEVEVQA-KTVTELVTKKKPKAEGYAEGDLTLYH--- 250

  Fly   257 EGKTSSSD--ESKSNLEYVYDA---VMDD---ASYPLEFKEI 290
              :||.:|  .:.:.::::..|   ::||   |.:|...::|
Human   251 --RTSVTDFLRAANPVDFLSKASEIMVDDEELAQHPATTEDI 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5220	NP_650590.1	RlmE	3..211	CDD:223370	71/207 (34%)
FTSJ3	NP_060117.3	RlmE	8..203	CDD:223370	70/204 (34%)
		DUF3381	232..400	CDD:288694	14/64 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..370
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..510
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..653
		Spb1_C	644..834	CDD:285075
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	811..847
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0293
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1362679at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820