Protein Alignment CG18213 and Smyd3

DIOPT Version :10

• Sequence 1: NP_650589.2
• Gene: CG18213 / 42055
• FlyBaseID: FBgn0038470
• Length: 879
• Species: Drosophila melanogaster
• Sequence 2: NP_081464.1
• Gene: Smyd3 / 69726
• MGIID: 1916976
• Length: 428
• Species: Mus musculus
• Alignment Length: 325
• Identity: 60/325 - (18%)
• Similarity: 115/325 - (35%)
• Gaps: 93/325 - (28%)

  Fly   238 KSGGVFASCDVPKGEIVLVENPVYFQF--SAPFLNCELCGVHQQQLYTCDNCRYRSYCSKSCMKS 300
            :..|:.|...:..||::...:|:.:..  .:..:.|:.|.:.:::|..|..||...|||..|.|.
Mouse    14 RGNGLRAVAPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRIAKYCSAKCQKK 78

  Fly   301 DAEVHQYECYGYKI--GLIPMLEANMLFRLFCEAGEYILPAIVD------------YAMDGGILS 351
            ....|:.||...|.  ...|.....:|.|        ::..::|            |.::..|..
Mouse    79 AWPDHRRECSCLKSCKPRYPPDSVRLLGR--------VIVKLMDEKPSESEKLYSFYDLESNISK 135

  Fly   352 NPRD--------AWTFILEHAQEEEKTYNLVGELLATAPDYNLLTREKYTEIVTTAFRLSVFIYN 408
            ...|        |.||  :|...||     :.:.....|.::|.  |.:.:::..:|.:.
Mouse   136 LTEDKKEGLRQLAMTF--QHFMREE-----IQDASQLPPSFDLF--EAFAKVICNSFTIC----- 186

  Fly   409 DTRLAEKYFYLLALVKTDLITVMAAI---------LLRLGGHVLLNSQRD-------NLCYRQRE 457
            :..:.|        |...|...|:.:         ::..|.|:||.:.|:       .:||
Mouse   187 NAEMQE--------VGVGLYPSMSLLNHSCDPNCSIVFNGPHLLLRAVREIEAGEELTICY---- 239

  Fly   458 GIDAMNENNDE---------FENCGILPMPTDRISANVFSYYGVNAITDFVDCYNNVHDSLAEIE 513
             :|.:..:.:.         || |..:...|....|::        :|.....:..|.:||.:||
Mouse   240 -LDMLMTSEERRKQLRDQYCFE-CDCIRCQTQDKDADM--------LTGDEQIWKEVQESLKKIE 294

  Fly   514  513
            Mouse   295  294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18213	NP_650589.2	None
Smyd3	NP_081464.1	SET_SMYD3	5..268	CDD:380980	52/289 (18%)
		zf-MYND	49..87	CDD:460312	12/37 (32%)
		C-terminal domain, essential for histone methyltransferase activity, nuclear localization and mediates interaction with HSP90AA1. /evidence=ECO:0000250|UniProtKB:Q9H7B4	272..428		7/31 (23%)