Protein Alignment CG18213 and Smyd4

DIOPT Version :10

• Sequence 1: NP_650589.2
• Gene: CG18213 / 42055
• FlyBaseID: FBgn0038470
• Length: 879
• Species: Drosophila melanogaster
• Sequence 2: NP_001099280.1
• Gene: Smyd4 / 287525
• RGDID: 1307369
• Length: 801
• Species: Rattus norvegicus
• Alignment Length: 823
• Identity: 140/823 - (17%)
• Similarity: 249/823 - (30%)
• Gaps: 320/823 - (38%)

  Fly     7 YMG---------SEPRPEASE----YITMSEAM--------CPRNLIEC-------ELFLKILRK 43
            |||         |..||...:    |...|.|:        |.::::..       .|..|::.:
  Rat    84 YMGAAVLYSKGVSHSRPNTEDISLCYANRSAALFHLGQHEACLKDIVRAGMHGYPERLQPKLMIR 148

  Fly    44 TTDKVFLDFSEVAEGCLNISKKCMNMKSPTVLKMTLQSLDEIICRAPSASPTCVDAIMARSV--L 106
            .|:            ||      :|:......:.|:..|:..:...|:..|:. ..|:.|:|  |
  Rat   149 KTE------------CL------VNLGRLQEARQTISDLENSLTTKPTLMPSS-HQILQRNVQQL 194

  Fly   107 YIKNNQNTTACNDLLYYESLDPALKTAEGTIISQILHCICLFVNREYEASKDKLSVVKGLIEDGT 171
            .:|..:..|      ..||...||..|                                 :||
  Rat   195 KMKIQEKET------LPESFPAALTKA---------------------------------LED-- 218

  Fly   172 LADRSEVSPFLALIEQHEERINQARINVEFCKKVQTENFVPFKGFKLTRKIPFASQACDYSEKSI 236
                      :||.|:::: |:.|.::|..|..       |.||..|.
  Rat   219 ----------MALGEENKQ-ISGASLSVSLCTD-------PLKGRHLV----------------- 248

  Fly   237 EKSGGVFASCDVPKGEIVL--------------------VENPVYFQFSAPFLNCELCGVHQQQL 281
                   |:.|:..||:::                    :||....:.::..|.|..|..|....
  Rat   249 -------ATKDILPGELLVKEDAFVSVLNPGEMPPLRHCLENKWDTRVTSADLYCHRCLRHTLAT 306

  Fly   282 YTCDNCRYRSYCSKSCMKSDAE-VHQYEC--------------YGYKIGLIPMLE-ANMLFRLFC 330
            ..|..|.|..|||:.|::...: .|..||              ...::.|:...| .:.:.|:.|
  Rat   307 VPCGGCSYAKYCSQECVQQAWDHYHSTECSLGGLLLTLGVFCHVALRMTLLARFEDVDRVIRMIC 371

  Fly   331 E---AGEYILPAIVD------YAMDG-------------------GILSNPRDAWTFILEHAQEE 367
            :   ..:..||...|      |...|                   |...|..||...:|.|.::.
  Rat   372 DKTGRKDTCLPESKDLVKTFGYTNQGESEENSETCEPSIPGCNVNGKYENNYDAVLSLLPHTEKH 436

  Fly   368 EKTYN---------LVGELLAT----------APDYNLLTREKYTEIVT--------------TA 399
            ...:.         |..:|.||          :|....:|....|::..              .|
  Rat   437 SPEHKFICAVSVSALCRQLKATSLQAQTTGLKSPRLKAVTPGLCTDLTVWGVAMLQHMLQLQCNA 501

  Fly   400 FRLSVFIY-----------NDTRLAEKYFYLLALVK------------TDLITVMAAILLRLGGH 441
            ..::...|           ...|||...|.:::|:.            :.:.|:.||..:..|..
  Rat   502 QAITSICYAGSKESIITNSRQVRLATGVFPVVSLLNHSCSPNTSVSFTSTVATIRAAQQIAKGQE 566

  Fly   442 VLLNSQRDNLCY---RQREGIDAMNE--NNDEFENCGILPMPTDRISANV---FSYYGVNAI--- 495
            :|       .||   ..|.|:....:  ::..|.:|.......:.:.|.|   :..:..|..
  Rat   567 IL-------HCYGPHESRMGVAERQQRLSSQYFFDCSCPACHAETLRAAVAPRWEAFCCNTCRVP 624

  Fly   496 ---TDFVDCYNNVHDSLAEIEPEYPEKFSNDSPIFRFADRLHSICMQKYEIEAVEDLVSADTLPE 557
               .|.:.|.|              |..:|.....|...||..:   :.::...:.|:.:|. ||
  Rat   625 MQGNDVLSCSN--------------ESCTNSVSRDRLVSRLQDL---QQQVHTAQKLLRSDR-PE 671

  Fly   558 QEINEILQIFNTSQRCQLLTNIAKYFQQFVYQYFHKIEN-TVQLKSTL----------CVTLKAF 611
            |.|.::|:       ||   ..|:.|....:....:||: ..|..:||          ..:|:..
  Rat   672 QAIQQLLE-------CQ---RAAENFLSAEHTVLGEIEDGLAQAYATLGDWRQSAAHVQKSLQVV 726

  Fly   612 KQNCGTKNIK--------AIFLPNGKVVGVTAKKVHKGEELVI 646
            :...|..:::        |..|.||..|......:.|.|::::
  Rat   727 EARHGPSSVEIGHELFKLAQVLFNGLAVPEALDAIWKAEKILL 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18213	NP_650589.2	None
Smyd4	NP_001099280.1	3a0801s09	7..>211	CDD:273380	28/151 (19%)
		TPR repeat	68..96	CDD:276809	3/11 (27%)
		TPR repeat	101..136	CDD:276809	4/34 (12%)
		SET	239..>269	CDD:394802	8/60 (13%)
		zf-MYND	296..335	CDD:460312	11/38 (29%)
		SET_SMYD4	418..600	CDD:380934	30/188 (16%)
		TPR_12	661..728	CDD:315987	17/77 (22%)