Protein Alignment CG18213 and SMYD4

DIOPT Version :10

• Sequence 1: NP_650589.2
• Gene: CG18213 / 42055
• FlyBaseID: FBgn0038470
• Length: 879
• Species: Drosophila melanogaster
• Sequence 2: NP_443160.2
• Gene: SMYD4 / 114826
• HGNCID: 21067
• Length: 804
• Species: Homo sapiens
• Alignment Length: 735
• Identity: 137/735 - (18%)
• Similarity: 234/735 - (31%)
• Gaps: 288/735 - (39%)

  Fly    17 SEYITMSEAMCPRNLI---------ECELFLKIL----------------RKTTDKVF--LDFSE 54
            |..:|:|.|...|::.         |.|||||.|                |:..:|.|  .|::
Human    22 SVQVTISTAETLRDIFLHSSSLLQPEDELFLKRLSKGYLVGKDSDAPLFYREEGNKKFQEKDYT- 85

  Fly    55 VAEGCLNISKKCMNMKSPTVLKMTLQSLDEIICRAPSASPTCVDAIMARSVLYIKNNQNTTACND 119
               |...:..|.::...|....|:|       |.|            .||.......|..|...|
Human    86 ---GAAVLYSKGVSHSRPNTEDMSL-------CHA------------NRSAALFHLGQYETCLKD 128

  Fly   120 LL------YYESLDP--ALKTAEGTIISQILHCICLF-VNREYEASKDKLSVVKGLIEDGTLADR 175
            :.      |.|.|.|  .|:.||           ||. :.|..|||:....:.:.......|||
Human   129 INRAQTHGYPERLQPKIMLRKAE-----------CLVALGRLQEASQTISDLERNFTATPALAD- 181

  Fly   176 SEVSPFLALIEQHEERINQARINVEFCKKVQTENFVPFKGFKLTRKIPFA-------------SQ 227
                    ::.|..:| |..|:.:    |:|.::       .||...|.|             ::
Human   182 --------VLPQTLQR-NLHRLKM----KMQEKD-------SLTESFPAALAKTLEDAALREENE 226

  Fly   228 ACDYSEKSIE------KSGGVFASCDVPKGEIVLVEN------------PVYFQFSAPF------ 268
            ....:..||.      |...:.|:.|:..||:::.|:            |.:....:.:
Human   227 QLSNASSSIGLCVDPLKGRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTN 291

  Fly   269 --LNCELCGVHQQQLYTCDNCRYRSYCSKSCMKSDAEV-HQYECYGYKIGLIPMLEANMLFRLFC 330
              |.|..|..|......||.|.|..|||:.|::...|: |:.||        |:
Human   292 GDLYCHRCLKHTLATVPCDGCSYAKYCSQECLQQAWELYHRTEC--------PL----------- 337

  Fly   331 EAGEYILPAIVDYAMDGGILSNPRDAWTFILEHAQEEEKTYNLVGELLATAPDYNLLTREKYTEI 395
                            ||:                                    |||...:..|
Human   338 ----------------GGL------------------------------------LLTLGVFCHI 350

  Fly   396 VTTAFRLSVFI-YND-----TRLAEKYFYLLALVKTDLITVMAAILLRLGGHVLLNSQRDNLCYR 454
               |.||::.: :.|     |:|.:|      :...|:....:            |:|...|.|
Human   351 ---ALRLTLLVGFEDVRKIITKLCDK------ISNKDICLPES------------NNQVKTLNY- 393

  Fly   455 QREGIDAMNENNDEFENCGILPMPTDRISANVFSYYGVNAITDFVDCYNNVHDSLAEIEPEYPEK 519
               |:....:|.:..|.    |:|            |.:....:.:.||.|.:.|...|
Human   394 ---GLGESEKNGNIVET----PIP------------GCDINGKYENNYNAVFNLLPHTE------ 433

  Fly   520 FSNDSPIFRFADRLHSICMQKY--EIEAVEDLVSADTLPEQEI--NEILQIFNTSQRCQLLT--- 577
              |.||..:|   |.::|:...  ::||    .|...:|.:.|  :..|:...|.:.|..:|
Human   434 --NHSPEHKF---LCALCVSALCRQLEA----ASLQAIPTERIVNSSQLKAAVTPELCPDVTIWG 489

  Fly   578 -NIAKYFQQFV--YQYFHKIENT------------VQLKSTLCVTLKAFKQNCGTKNIKAIFLPN 627
             .:.::..|..  .|....|::|            |:|.:.:...:.....:| :.|....|:..
Human   490 VAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHSC-SPNTSVSFIST 553

  Fly   628 GKVVGVTAKKVHKGEELVIC 647
            ...:. .::::.||:|::.|
Human   554 VATIR-ASQRIRKGQEILHC 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18213	NP_650589.2	None
SMYD4	NP_443160.2	NlpI	<66..>171	CDD:443815	29/138 (21%)
		TPR repeat	68..96	CDD:276809	6/31 (19%)
		TPR repeat	101..135	CDD:276809	9/52 (17%)
		TPR repeat	143..171	CDD:276809	10/38 (26%)
		SET	239..>269	CDD:394802	6/29 (21%)
		zf-MYND	296..335	CDD:460312	13/38 (34%)
		SET_SMYD4	404..602	CDD:380934	37/202 (18%)
		TPR_12	660..726	CDD:315987
		TPR_12	698..771	CDD:315987