DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4009 and EPX

DIOPT Version :9

Sequence 1:	NP_001262655.1	Gene:	CG4009 / 42054	FlyBaseID:	FBgn0038469	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_000493.1	Gene:	EPX / 8288	HGNCID:	3423	Length:	715	Species:	Homo sapiens

Alignment Length:	673	Identity:	198/673 - (29%)
Similarity:	299/673 - (44%)	Gaps:	132/673 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SLDALIKEFMPKYNGN-NVHNSWAEPSASQQPLRCGVPPRNC-LNDTRNL---HYRTLDGSCNNL 105
            :|..|.::..|:.:|. ||.:...||.     ||.......| |.|....   .|||:.|.|||.
Human    96 ALGLLEEKLQPQRSGPFNVTDVLTEPQ-----LRLLSQASGCALRDQAERCSDKYRTITGRCNNK 155

  Fly   106 LYP-----------------------EFGIAVSRYRR--LLP-----PRQVEQAPNARLISLSLY 140
            ..|                       .||...||.|.  |||     ..|:.:.||.||.|
Human   156 RRPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVRAVSNQIVRFPNERLTS---- 216

  Fly   141 GEQTRNDRFRTMAAMQWGQFVAHDISQLSTQG-------APQDC---CAEPRHPRCLPINLPRGG 195
                  ||.|.:..||||||:.||: ..|.:.       |..||   ||:  .|.|.||.:|...
Human   217 ------DRGRALMFMQWGQFIDHDL-DFSPESPARVAFTAGVDCERTCAQ--LPPCFPIKIPPND 272

  Fly   196 PIAYHTGKTCLHFARSVSDADAICPKVEEPQPEKLTVATAYLDLSSIYGNNPSQNRKVRLFKGGL 260
            | .....:.|:.|.||...    ||:.:.....::...|:::|.|.:||:..|.:.::|
Human   273 P-RIKNQRDCIPFFRSAPS----CPQNKNRVRNQINALTSFVDASMVYGSEVSLSLRLR------ 326

  Fly   261 LKTSY-----------TNGQHWLPVSQNENGEC-----GAKSECYIVPDIRNRFSPTIALLQTLL 309
            .:|:|           .||:..||.....:..|     .|:..|::..|.|:..:|.:|.:.||.
Human   327 NRTNYLGLLAINQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSTETPKLAAMHTLF 391

  Fly   310 VREHNRLAENLALINPDHSDERIFQEARKINIAQFQKITYYDWLPLFVG-----RTYTYLNGLIY 369
            :|||||||..|..:||..:.::::.|||||..|..|.|||.|:|||.:|     ||..:..|
Human   392 MREHNRLATELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGKARARRTLGHYRG--- 453

  Fly   370 PVEPTEYVNDYDETVNPAAYAEFSAAAFRYAHTQI-PGWFSLVAPNRRS--NRTMRLSDFLDRTE 431
                      |...|:|.. |.....|||:.||.: |..|.|.:..|.|  |..:.||.....:.
Human   454 ----------YCSNVDPRV-ANVFTLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLSSAFFASW 507

  Fly   432 TIRLLDTSDNFDALLRGLATQLHK--RSDGNIDREIKHYFNRKEFEEYGSDLKSIDIQRARDFGL 494
            .|..   ....|.:||||.....|  |.|..:..|::....| :....|.||.::::||:||.||
Human   508 RIVY---EGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFR-QVRRIGLDLAALNMQRSRDHGL 568

  Fly   495 ASYNDVREFCGLRRAVDWADFAHEIPGEKISLLRR---LYATPDDVELGVGGTLEYHVPDALFGP 556
            ..||..|.||||.:..:.|..:..:..:  .|.|:   ||.|||::::.:|...|..:|.|..||
Human   569 PGYNAWRRFCGLSQPRNLAQLSRVLKNQ--DLARKFLNLYGTPDNIDIWIGAIAEPLLPGARVGP 631

  Fly   557 TLLCVIGKQFLNTRRGDRFFFERENEGGFSRAQLAEIRKVSLSSLFCSNANYLHLIQPNVF---V 618
            .|.|:...||...|.||||::::  .|.|::.|...:.::|||.:.|.|.. :..:..::|   :
Human   632 LLACLFENQFRRARDGDRFWWQK--RGVFTKRQRKALSRISLSRIICDNTG-ITTVSRDIFRANI 693

  Fly   619 FPNSHNLLLNCNFIPQIDLSKWQ 641
            :|..   .:||:.||:::||.|:
Human   694 YPRG---FVNCSRIPRLNLSAWR 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4009	NP_001262655.1	An_peroxidase_like	77..>367	CDD:265428	105/354 (30%)
		An_peroxidase	95..610	CDD:281139	176/583 (30%)
		peroxinectin_like	228..605	CDD:188655	124/405 (31%)
EPX	NP_000493.1	An_peroxidase	145..683	CDD:281139	176/584 (30%)
EPX	NP_000493.1	myeloperoxidase_like	289..699	CDD:188656	129/445 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150046
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750