DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4009 and PXDN

DIOPT Version :9

Sequence 1:	NP_001262655.1	Gene:	CG4009 / 42054	FlyBaseID:	FBgn0038469	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_036425.1	Gene:	PXDN / 7837	HGNCID:	14966	Length:	1479	Species:	Homo sapiens

Alignment Length:	742	Identity:	217/742 - (29%)
Similarity:	330/742 - (44%)	Gaps:	156/742 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VVLSVLSVAVATKCPYSAMEPSLSRSKRSSFDIRPGVSDGSLDA--------------------- 49
            |..|::. |:||      ::.:::.::...||.||. |...|.|
Human   624 VATSIVE-AIAT------VDRAINSTRTHLFDSRPR-SPNDLLALFRYPRDPYTVEQARAGEIFE 680

  Fly    50 ----LIKE-----FMPKYNGNNVH-NSWAEPSASQQPLR-------CGVPPR--NCLNDTRNLHY 95
                ||:|     .|...||.:.| |....|    |.|.       |....|  ||.:...:..|
Human   681 RTLQLIQEHVQHGLMVDLNGTSYHYNDLVSP----QYLNLIANLSGCTAHRRVNNCSDMCFHQKY 741

  Fly    96 RTLDGSCNNLLYPEFGIAVSRYRRLL---------PPRQV--------EQAPNARLISLSLYGEQ 143
            ||.||:||||.:|.:|.:::.:.|||         .||.:        ...|..||:|.:|.|.:
Human   742 RTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTLIGTE 806

  Fly   144 --TRNDRFRTMAAMQWGQFVAHDISQLSTQGA--------PQDC---CAEPRHPRCLPINLPRGG 195
              |.:::| |...||||||:.||:.  ||..|        .|.|   |:  ..|.|..:.:|...
Human   807 TVTPDEQF-THMLMQWGQFLDHDLD--STVVALSQARFSDGQHCSNVCS--NDPPCFSVMIPPND 866

  Fly   196 PIAYHTGKTCLHFARSVSDADAICPK------VEEPQP-EKLTVATAYLDLSSIYGNNPSQNRKV 253
            ..| .:|..|:.|.||    ..:|..      :....| |::...|:|:|.|::||:...:.|.:
Human   867 SRA-RSGARCMFFVRS----SPVCGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTEHEARSI 926

  Fly   254 R-------LFKGGLLKTSYTNGQHWLPVSQNENGECGAKSE------CYIVPDIRNRFSPTIALL 305
            |       |.:.|:::.|   |:..||.:.....|| .:.|      |::..|.|......:..:
Human   927 RDLASHRGLLRQGIVQRS---GKPLLPFATGPPTEC-MRDENESPIPCFLAGDHRANEQLGLTSM 987

  Fly   306 QTLLVREHNRLAENLALINPDHSDERIFQEARKINIAQFQKITYYDWLPLFVGRTYTYLNGLIYP 370
            .||..|||||:|..|..:||....:.|:.|.|||..|:.|.|||..|||..:|.......|
Human   988 HTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHWLPKILGEVGMRTLG---- 1048

  Fly   371 VEPTEYVNDYDETVNPAAYAEFSAAAFRYAHTQI-PGWFSL---VAPNRRSNRTMRLSDFLDRTE 431
                || :.||..:|...:..|:.||||:.||.: |..:.|   ..|..:.:..:..:.|    .
Human  1049 ----EY-HGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQDHLPLHKAFF----S 1104

  Fly   432 TIRLLDTSDNFDALLRGLATQLHKRSDGNIDREIKHYFNRKEFEEYGS-------DLKSIDIQRA 489
            ..|::: ....|.|||||.....|.      |......|.:..|...|       ||.:|:|||.
Human  1105 PFRIVN-EGGIDPLLRGLFGVAGKM------RVPSQLLNTELTERLFSMAHTVALDLAAINIQRG 1162

  Fly   490 RDFGLASYNDVREFCGLRRAVDWADFAHEIPGEKI-SLLRRLYATPDDVELGVGGTLEYHVPDAL 553
            ||.|:..|:|.|.:|.|..|..:.|..:||...:| ..|:|||.:..:::|.....:|..||.:.
Human  1163 RDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGSTLNIDLFPALVVEDLVPGSR 1227

  Fly   554 FGPTLLCVIGKQFLNTRRGDRFFFERENEGGFSRAQLAEIRKVSLSSLFCSNANYLHLIQPNVF- 617
            .||||:|::..||...|.|||.::  ||.|.||.|||.:|::.||:.:.|.||:.:..:|.:||
Human  1228 LGPTLMCLLSTQFKRLRDGDRLWY--ENPGVFSPAQLTQIKQTSLARILCDNADNITRVQSDVFR 1290

  Fly   618 --VFPNSHNLLLNCNFIPQIDLSKWQD 642
              .||:.:.   :|:.||::||..|||
Human  1291 VAEFPHGYG---SCDEIPRVDLRVWQD 1314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4009	NP_001262655.1	An_peroxidase_like	77..>367	CDD:265428	101/348 (29%)
		An_peroxidase	95..610	CDD:281139	177/576 (31%)
		peroxinectin_like	228..605	CDD:188655	125/401 (31%)
PXDN	NP_036425.1	leucine-rich repeat	45..63	CDD:275380
		leucine-rich repeat	66..87	CDD:275380
		LRR 1	87..108
		LRR_4	110..151	CDD:289563
		LRR_8	111..170	CDD:290566
		LRR 2	111..132
		leucine-rich repeat	112..135	CDD:275378
		LRR_4	135..175	CDD:289563
		LRR 3	135..156
		leucine-rich repeat	136..159	CDD:275378
		LRR_8	158..>195	CDD:290566
		LRR 4	159..180
		leucine-rich repeat	160..183	CDD:275378
		leucine-rich repeat	184..196	CDD:275378
		TPKR_C2	192..243	CDD:301599
		Ig	246..333	CDD:299845
		I-set	246..333	CDD:254352
		I-set	342..429	CDD:254352
		Ig	346..429	CDD:299845
		I-set	433..519	CDD:254352
		Ig3_Peroxidasin	446..519	CDD:143222
		I-set	525..611	CDD:254352
		Ig4_Peroxidasin	542..610	CDD:143223
		An_peroxidase	741..1282	CDD:281139	177/576 (31%)
		peroxidasin_like	864..1303	CDD:188658	141/472 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1342..1380
		VWC	1415..1470	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150052
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750