DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4009 and Lpo

DIOPT Version :9

Sequence 1:	NP_001262655.1	Gene:	CG4009 / 42054	FlyBaseID:	FBgn0038469	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_536345.2	Gene:	Lpo / 76113	MGIID:	1923363	Length:	710	Species:	Mus musculus

Alignment Length:	718	Identity:	205/718 - (28%)
Similarity:	303/718 - (42%)	Gaps:	130/718 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RVFLVVLSVLSVAVATKCPYSAMEPS--LSRSK-RSSFDIRPG-VSDGSLDALIKEFMPKYNGNN 62
            :.||.....|.:|:.||. :|....|  |..:| |:...||.| |.:.||..| .:|:....|..
Mouse    47 KAFLDSRDRLKMAMTTKI-HSTRHLSDYLKHAKGRTRTAIRSGQVWEESLKKL-SQFLTNVTGQG 109

  Fly    63 VH---NSW---AEPSASQQPLRCGVPPRNCLNDTRNLHYRTLDGSCNNLLYPEFGIAVSRYRRLL 121
            :.   .||   .:|.|.........|            |||:.|.|||...|..|.|.....|.|
Mouse   110 LDLTLLSWEAGCDPPAPTMTCNISSP------------YRTITGYCNNRKNPALGSANRALARWL 162

  Fly   122 P--------------------------PRQVEQAPNARLISLSLYGEQTRNDRFRTMAAMQWGQF 160
            |                          ||:|.....|.|      .|:...|:.|:|..|||||.
Mouse   163 PAEYEDGLSLPYGWTPGKMRNGFPLPQPREVSNQIAAYL------NEEDVLDQKRSMLFMQWGQI 221

  Fly   161 VAHDI---------SQLSTQGAPQDCCAEPRHPRCLPINLPRGGPIAYHTGKTCLHFARSVSDAD 216
            |.||:         |...|:....:.|.:  ...|.||..|.|.|.....|| |:.|.|    |.
Mouse   222 VDHDMDFAPETEMGSDTYTKAQCDEHCIQ--GDNCFPIMFPPGDPKLKTQGK-CMPFFR----AG 279

  Fly   217 AIC--PKVEEPQPEKLTVATAYLDLSSIYGNNPSQNRKVRLFKG--GLLKTS---YTNGQHWLPV 274
            .:|  |..:....|::...|::||.|.:|...||...::|....  ||:..:   ..||:.:.|.
Mouse   280 FVCPTPPYKSLAREQINALTSFLDASLVYSPEPSLANRLRNLSSPLGLMAVNEEVSDNGRPFPPF 344

  Fly   275 SQNENGEC-----GAKSECYIVPDIRNRFSPTIALLQTLLVREHNRLAENLALINPDHSDERIFQ 334
            .:.:...|     .|...|::..|.|......:|...||.:|||||||..|:.:||....|.::|
Mouse   345 VKMKPSPCEVINATAGVPCFLAGDSRASEQILLATSHTLFIREHNRLATELSRLNPHWDRETLYQ 409

  Fly   335 EARKINIAQFQKITYYDWLPLFVGRTYTYLNGLIYPVEPTEYVNDYDETVNPAAYAEFSAAAFRY 399
            |||||..|..|..|:.|:||:.:|   ..:...|.|.:      .|:|:|:|.....|: .|.|:
Mouse   410 EARKIMGAFIQITTFRDYLPILLG---DEMQKWIPPYQ------GYNESVDPRISNVFT-FALRF 464

  Fly   400 AHTQIPG-----------WFSLVAPNRRSNRTMRLSDFLDRTETIRLLDTSDNFDALLRGLATQL 453
            .|.:||.           |.|      .|...:....|    .|.||: .....|.|:|||..:.
Mouse   465 GHLEIPSTVYRLDENYQPWGS------ESELPLHTVFF----NTWRLV-KDGGIDPLVRGLLAKN 518

  Fly   454 HKRSDGN--IDREIKHYFNRKEFEEYGSDLKSIDIQRARDFGLASYNDVREFCGLRRAVDWADFA 516
            .|....|  :..|:::...:.....:|.||.||:|||:||.|...||..|.||||.:.....:.:
Mouse   519 AKLMHQNKMMTGELRNKLFQPNHTIHGFDLASINIQRSRDHGQPGYNSWRAFCGLSQPKTLEELS 583

  Fly   517 HEIPGEKIS-LLRRLYATPDDVELGVGGTLEYHVPDALFGPTLLCVIGKQFLNTRRGDRFFFERE 580
            ..:..|.:: .|..||.||.::::.:|...|..|.....||.|.|::|:||...|.||||::  |
Mouse   584 AVMKNEVLAKKLMDLYGTPSNIDIWLGAVAEPLVHRGRVGPLLTCLLGQQFQRIRDGDRFWW--E 646

  Fly   581 NEGGFSRAQLAEIRKVSLSSLFCSNANY----LHLIQPNVFVFPNSHNLLLNCNFIPQIDLSKWQ 641
            |.|.|:..|...::|:|.|.|.|.|...    |:..|.|  .:|:.   .::|:.|.::|||.|.
Mouse   647 NPGVFTEKQRESLQKMSFSRLVCDNTGIDKVPLNPFQAN--AYPHG---FVDCSSIDKLDLSPWA 706

  Fly   642 DLR 644
            .::
Mouse   707 SVK 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4009	NP_001262655.1	An_peroxidase_like	77..>367	CDD:265428	94/336 (28%)
		An_peroxidase	95..610	CDD:281139	170/579 (29%)
		peroxinectin_like	228..605	CDD:188655	122/400 (31%)
Lpo	NP_536345.2	myeloperoxidase_like	281..692	CDD:188656	129/438 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840096
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740