DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4009 and PTGS2

DIOPT Version :9

Sequence 1:	NP_001262655.1	Gene:	CG4009 / 42054	FlyBaseID:	FBgn0038469	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_000954.1	Gene:	PTGS2 / 5743	HGNCID:	9605	Length:	604	Species:	Homo sapiens

Alignment Length:	399	Identity:	98/399 - (24%)
Similarity:	166/399 - (41%)	Gaps:	85/399 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 LDLSSIYGNNPSQNRKVRLFKGGLLKTSYTNGQHWLPVSQNENGECGAKSECYIVPDIRN--RFS 299
            :||:.|||...::.||:||||.|.:|....:|:.:.|..::      .::|....|.:..  ||:
Human   214 VDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKD------TQAEMIYPPQVPEHLRFA 272

  Fly   300 ---------PTIALLQTLLVREHNRLAENLALINPDHSDERIFQEARKINIAQFQKITYYDWLPL 355
                     |.:.:..|:.:|||||:.:.|...:|:..||::||.:|.|.|.:..||...|::
Human   273 VGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYV-- 335

  Fly   356 FVGRTYTYLNGLIYPV--EPTEYVNDYDETVNPAAYAEFSAAAFRYAHTQIPGWFSLVAPNRRSN 418
                  .:|:|..:.:  :|....|...:..|..| |||:  ...:.|..:|..|.:      .:
Human   336 ------QHLSGYHFKLKFDPELLFNKQFQYQNRIA-AEFN--TLYHWHPLLPDTFQI------HD 385

  Fly   419 RTMRLSDFLDRTETIRLLDTSDNFDALLRGLATQ----------LHKRSDGNID--REIKHYFNR 471
            :......|:.....:.....:...::..|.:|.:          :.|.|..:||  |::|:
Human   386 QKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKY---- 446

  Fly   472 KEFEEYGSDLKSIDIQRARDFGLASYNDVREFCGLRRAVDWADFAHEIPGEKISLLRRLYATPDD 536
            :.|.||          |.| |.|..|....|..|.:          |:..|    |..||...|.
Human   447 QSFNEY----------RKR-FMLKPYESFEELTGEK----------EMSAE----LEALYGDIDA 486

  Fly   537 VELGVGGTLEYHVPDALFGPTLLCVIGKQF-LNTRRGDRF----FFERENEGGFSRAQLAEIRKV 596
            |||.....:|...|||:||.|:: .:|..| |....|:..    :::....||....|:  |...
Human   487 VELYPALLVEKPRPDAIFGETMV-EVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQI--INTA 548

  Fly   597 SLSSLFCSN 605
            |:.||.|:|
Human   549 SIQSLICNN 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4009	NP_001262655.1	An_peroxidase_like	77..>367	CDD:265428	39/140 (28%)
		An_peroxidase	95..610	CDD:281139	98/399 (25%)
		peroxinectin_like	228..605	CDD:188655	97/397 (24%)
PTGS2	NP_000954.1	EGF_CA	19..54	CDD:238011
PTGS2	NP_000954.1	prostaglandin_endoperoxide_synthase	75..562	CDD:188648	98/399 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810