DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4009 and Pxdn

DIOPT Version :9

Sequence 1:	NP_001262655.1	Gene:	CG4009 / 42054	FlyBaseID:	FBgn0038469	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001258190.1	Gene:	Pxdn / 554172	RGDID:	1560694	Length:	1475	Species:	Rattus norvegicus

Alignment Length:	767	Identity:	218/767 - (28%)
Similarity:	330/767 - (43%)	Gaps:	188/767 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLSVLSVAVATKC----PYSA---------MEPSLSRSKRSSFDIRPGVSDGSLDA--------- 49
            |..||||.|....    ||.|         ::.:::.::...||.||. |...|.|
  Rat   602 VSMVLSVNVPDVSRNGDPYVATSIVEAIATVDRAINSTRTHLFDSRPR-SPNDLLALFRYPRDPY 665

  Fly    50 ----------------LIKE-----FMPKYNGNNVH-NSWAEP---SASQQPLRCGVPPR--NCL 87
                            ||:|     .|...||.:.| |....|   |.......|....|  ||.
  Rat   666 TVGQARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLSLIANLSGCTAHRRVNNCS 730

  Fly    88 NDTRNLHYRTLDGSCNNLLYPEFGIAVSRYRRLL---------PPRQVEQ--------APNARLI 135
            :...:..|||.||:||||.:|.:|.:::.:.|||         .||.:..        .|..||:
  Rat   731 DMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKAVYENGFNTPRGINSQRQYNGHVLPMPRLV 795

  Fly   136 SLSLYGEQ--TRNDRFRTMAAMQWGQFVAHDISQLSTQGA--------PQDC---CAEPRHPRCL 187
            |.:|.|.:  |.:::| |...||||||:.||:.  ||..|        .|.|   |:  ..|.|.
  Rat   796 STTLIGTEVITPDEQF-THMLMQWGQFLDHDLD--STVVALSQARFSDGQHCSSVCS--NDPPCF 855

  Fly   188 PINLPRGGPIAYHTGKTCLHFARSVSDADAICPK------VEEPQP-EKLTVATAYLDLSSIYGN 245
            .:.:|...| ...:|..|:.|.||    ..:|..      :....| |::...|:|:|.|::||:
  Rat   856 SVMIPPNDP-RVRSGARCMFFVRS----SPVCGSGMTSLLMNSVYPREQINQLTSYIDASNVYGS 915

  Fly   246 NPSQNRKVR-------LFKGGLLKTSYTNGQHWLPVSQNENGECGAKSE------CYIVPDIRNR 297
            ...:.|.:|       |.:.|:::.|   |:..||.:.....|| .:.|      |::..|.|..
  Rat   916 TDHEARSIRDLASHRGLLRQGIVQRS---GKPLLPFATGPPTEC-MRDENESPIPCFLAGDHRAN 976

  Fly   298 FSPTIALLQTLLVREHNRLAENLALINPDHSDERIFQEARKINIAQFQKITYYDWLPLFVGRTYT 362
            ....:..:.||..|||||:|..|..:||....:.::.|.|||..|:.|.|||..|||..:|....
  Rat   977 EQLGLTSMHTLWFREHNRIAAELLKLNPHWDGDTVYHETRKIVGAEIQHITYRHWLPKILGEVGM 1041

  Fly   363 YLNGLIYPVEPTEYVNDYDETVNPAAYAEFSAAAFRYAHTQIPGWFSLVAPNRRSNRTMRLSDFL 427
            .:.|        || ..||.:||...:..|:.||||:.||       |:.|
  Rat  1042 KMLG--------EY-RGYDPSVNAGIFNAFATAAFRFGHT-------LINP-------------- 1076

  Fly   428 DRTETIRLLDTSDNFDALLRGLATQLHKR--------SDGNIDREIKHYF-------------NR 471
                  .|....:||:.:.:| ...|||.        ::|.||..::..|             |.
  Rat  1077 ------LLYRLDENFEPIPQG-HVPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRIPSQLLNT 1134

  Fly   472 KEFEEYGS-------DLKSIDIQRARDFGLASYNDVREFCGLRRAVDWADFAHEIPGEKI-SLLR 528
            :..|...|       ||.:|:|||.||.|:..|:|.|.:|.|..|..:.|..:||....| ..|:
  Rat  1135 ELTERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAYTFEDLKNEIKSPVIREKLQ 1199

  Fly   529 RLYATPDDVELGVGGTLEYHVPDALFGPTLLCVIGKQFLNTRRGDRFFFERENEGGFSRAQLAEI 593
            |||.:..:::|.....:|..||.:..||||:|::..||...|.|||.::  ||.|.||.|||.::
  Rat  1200 RLYGSTLNIDLFPALMVEDLVPGSRLGPTLMCLLSTQFRRLRDGDRLWY--ENPGVFSPAQLTQL 1262

  Fly   594 RKVSLSSLFCSNANYLHLIQPNVF---VFPNSHNLLLNCNFIPQIDLSKWQD 642
            ::.||:.:.|.|::.:..:|.:||   .||:.::   :|..||::||..|||
  Rat  1263 KQTSLARILCDNSDNITRVQHDVFRVAEFPHGYS---SCEDIPRMDLRVWQD 1311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4009	NP_001262655.1	An_peroxidase_like	77..>367	CDD:265428	99/341 (29%)
		An_peroxidase	95..610	CDD:281139	175/593 (30%)
		peroxinectin_like	228..605	CDD:188655	124/418 (30%)
Pxdn	NP_001258190.1	leucine-rich repeat	42..60	CDD:275380
		leucine-rich repeat	63..84	CDD:275380
		LRR_4	107..148	CDD:289563
		LRR_8	108..167	CDD:290566
		leucine-rich repeat	109..132	CDD:275378
		LRR_4	132..172	CDD:289563
		leucine-rich repeat	133..156	CDD:275378
		LRR_8	155..>192	CDD:290566
		leucine-rich repeat	157..180	CDD:275378
		leucine-rich repeat	181..193	CDD:275378
		TPKR_C2	189..240	CDD:301599
		Ig	243..330	CDD:299845
		I-set	243..330	CDD:254352
		I-set	339..426	CDD:254352
		Ig	343..426	CDD:299845
		I-set	430..516	CDD:254352
		Ig3_Peroxidasin	443..516	CDD:143222
		I-set	522..608	CDD:254352	3/5 (60%)
		Ig4_Peroxidasin	539..607	CDD:143223	2/4 (50%)
		An_peroxidase	738..1279	CDD:281139	175/593 (30%)
		peroxidasin_like	861..1300	CDD:188658	139/489 (28%)
		VWC	1411..1466	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850