DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4009 and Tpo

DIOPT Version :9

Sequence 1:	NP_001262655.1	Gene:	CG4009 / 42054	FlyBaseID:	FBgn0038469	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_062226.2	Gene:	Tpo / 54314	RGDID:	3900	Length:	914	Species:	Rattus norvegicus

Alignment Length:	735	Identity:	218/735 - (29%)
Similarity:	318/735 - (43%)	Gaps:	170/735 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLSVLSVAVATKCPYSA----------MEPSLSRSKRSSFDIRPGVSDGSLDALIKEFMPKYNGN 61
            |||...:...:|.|.|.          ||.|:...||..       |..|.|||..:.:.
  Rat    67 VLSPAQLLSFSKLPESTSGAISRAAEIMETSIQVMKREQ-------SQFSTDALSADILA----- 119

  Fly    62 NVHN-SWAEPSASQQPLRCGVPPRNCLNDTRNLHYRTLDGSCNNLLYPEFGIAVSRYRRLLPP-- 123
            .:.| |...|  ...|.||   |..||.:    .||.:.|.|||..:|.:|.:.:...|.|||
  Rat   120 TIANLSGCLP--FMLPPRC---PDTCLAN----KYRPITGVCNNRDHPRWGASNTALARWLPPVY 175

  Fly   124 ------------------------RQVEQAPNARLISLSLYGEQ-TRNDRFRTMAAMQWGQFVAH 163
                                    |:|.:    .||.:|  .|. |.:|::.....: |||::.|
  Rat   176 EDGFSQPRGWNPNFLYHGFPLPPVREVTR----HLIQVS--NEAVTEDDQYSDFLPV-WGQYIDH 233

  Fly   164 DISQLSTQGAPQ-------DC--CAEPRHPRCLPINLPRGGPIAYHTGKT--CLHFARS-----V 212
            ||: |:.|....       ||  ..|.::| |.||.||.      ::.:|  ||.|.||     .
  Rat   234 DIA-LTPQSTSTAAFWGGVDCQLTCENQNP-CFPIQLPS------NSSRTTACLPFYRSSAACGT 290

  Fly   213 SDADAICPKVEEPQP-EKLTVATAYLDLSSIYGNNPSQNRKVRLF--KGGLLKTS---YTNGQHW 271
            .|..|:...:....| :::...|::||.|::||::|...:::|.:  ..|||:.:   ..:|:.:
  Rat   291 GDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDSGRAY 355

  Fly   272 LPVSQNENGEC----GA----KSECYIVPDIRNRFSPTIALLQTLLVREHNRLAENLALINPDHS 328
            ||.:   :..|    ||    ::.|::..|.|....|.:|.:.||.:|||||||.....||...|
  Rat   356 LPFA---SAACAPEPGAPHANRTPCFLAGDGRASEVPALAAVHTLWLREHNRLATAFKAINTHWS 417

  Fly   329 DERIFQEARKINIAQFQKITYYDWLPLFVG----RTYTYLNGLIYPVEPTEYVNDYDETVNPAAY 389
            ....:|||||:..|..|.||..|::|..:|    |.|         |.|.|   .|:.||||...
  Rat   418 ANTAYQEARKVVGALHQIITMRDYIPKILGPDAFRQY---------VGPYE---GYNPTVNPTVS 470

  Fly   390 AEFSAAAFRYAHTQIPGWFSLVAPNRRSNRTMRLSDFLDRTETIRL-----------LDTSDNFD 443
            ..||.||||:.|..:   ..||   ||.|     :||.|.||..||           |......|
  Rat   471 NVFSTAAFRFGHATV---HPLV---RRLN-----TDFQDHTELPRLQLHDVFFRPWRLIQEGGLD 524

  Fly   444 ALLRGLATQLHKRSDGNIDREIKHYFNRKEFEE-------YGS-DLKSIDIQRARDFGLASYNDV 500
            .::|||..:..|       .:::.....:|..|       .|: ||.|:::||.||.||..||:.
  Rat   525 PIVRGLLARPAK-------LQVQEQLMNEELTERLFVLSNVGTLDLASLNLQRGRDHGLPGYNEW 582

  Fly   501 REFCGLRRAVDWADFAHEIPGEK-ISLLRRLYATPDDVELGVGGTLEYHVPDALFGPTLLCVIGK 564
            ||||||.|....|:....|.... ::.:..||...|::::.:||..|..:|.|..||...|:|||
  Rat   583 REFCGLSRLETPAELNKAIANRSMVNKIMELYKHADNIDVWLGGLAEKFLPGARTGPLFACIIGK 647

  Fly   565 QFLNTRRGDRFFFERENEGGFSRAQLAEIRKVSLSSLFCSNANYLHLIQPNVF---VFPNSHNLL 626
            |....|.||||::  ||...|:.||..|:.|.||..:.|.|.. |..:..:.|   .||....
  Rat   648 QMKALRDGDRFWW--ENSHVFTDAQRQELEKHSLPRVICDNTG-LTRVPVDAFRIGKFPQDFE-- 707

  Fly   627 LNCNFIPQIDLSKWQDLRPQ 646
             :|..||.:||..|::..||
  Rat   708 -SCEEIPSMDLRLWRETFPQ 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4009	NP_001262655.1	An_peroxidase_like	77..>367	CDD:265428	99/350 (28%)
		An_peroxidase	95..610	CDD:281139	181/595 (30%)
		peroxinectin_like	228..605	CDD:188655	134/413 (32%)
Tpo	NP_062226.2	An_peroxidase	145..687	CDD:281139	180/591 (30%)
		thyroid_peroxidase	161..722	CDD:188657	184/614 (30%)
		CCP	730..783	CDD:153056
		EGF_CA	784..826	CDD:284955
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..907
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343972
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750