DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4009 and LPO

DIOPT Version :9

Sequence 1:	NP_001262655.1	Gene:	CG4009 / 42054	FlyBaseID:	FBgn0038469	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_006142.1	Gene:	LPO / 4025	HGNCID:	6678	Length:	712	Species:	Homo sapiens

Alignment Length:	704	Identity:	192/704 - (27%)
Similarity:	308/704 - (43%)	Gaps:	100/704 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RVFLVVLSVLSVAVATKCPYS-AMEPSLSRSKRSSFDIRPGVSDGSL-DALIKEFMPKYNGNNVH 64
            :.||...:.|..|::::.|.| .:...|..:|..:   |..:.:|.: :..:|....|.:..||.
Human    47 KAFLDSRTRLKTAMSSETPTSRQLSEYLKHAKGRT---RTAIRNGQVWEESLKRLRQKASLTNVT 108

  Fly    65 NSWAEPSASQQPLRCGVPPRNCLNDTRNLHYRTLDGSCNNLLYPEFGIAVSRYRRLLP------- 122
            :...:.::....:.||.|......|..: .|||:.|.|||...|..|.|.....|.||
Human   109 DPSLDLTSLSLEVGCGAPAPVVRCDPCS-PYRTITGDCNNRRKPALGAANRALARWLPAEYEDGL 172

  Fly   123 -------PRQVEQA---PNARLISLSLYG---EQTRNDRFRTMAAMQWGQFVAHDI-----SQLS 169
                   |.:....   |.||.:|..:.|   |:...|:.|::..|||||.|.||:     ::|.
Human   173 SLPFGWTPGKTRNGFPLPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELG 237

  Fly   170 TQGAPQDCCAE--PRHPRCLPINLPRGGPIAYHTGKTCLHFARSVSDADAIC--PKVEEPQPEKL 230
            :....:..|.|  .:...|.||..|...|.|...|| |:.|.|    |..:|  |..:....|::
Human   238 SSEYSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGK-CMPFFR----AGFVCPTPPYKSLAREQI 297

  Fly   231 TVATAYLDLSSIYGNNPSQNRKVRLFKG--GLLKTSYTNGQH---WLPVSQNENGEC-----GAK 285
            ...|::||.|.:|.:.||...::|....  ||:..:.....|   :||....:...|     .|:
Human   298 NALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKPSPCEFINTTAR 362

  Fly   286 SECYIVPDIRNRFSPTIALLQTLLVREHNRLAENLALINPDHSDERIFQEARKINIAQFQKITYY 350
            ..|::..|.|......:|...||.:|||||||..|..:||....|:::||||||..|..|.||:.
Human   363 VPCFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAFVQIITFR 427

  Fly   351 DWLPLFVGRTYTYLNGLIYPVEPTEYVNDYDETVNPAAYAEFSAAAFRYAHTQIPGWFSLVAPNR 415
            |:||:.:|   .::...|.|.:      .|.|:|:|.....|: .|||:.|.::|
Human   428 DYLPILLG---DHMQKWIPPYQ------GYSESVDPRISNVFT-FAFRFGHLEVP---------- 472

  Fly   416 RSNRTMRLSD----------------FLDRTETIRLLDTSDNFDALLRGLATQLHKRSDGN--ID 462
              :...||.:                |.:....::    ....|.|:|||..:..|....|  :.
Human   473 --SSMFRLDENYQPWGPEPELPLHTLFFNTWRMVK----DGGIDPLVRGLLAKKSKLMKQNKMMT 531

  Fly   463 REIKHYFNRKEFEEYGSDLKSIDIQRARDFGLASYNDVREFCGLRRAVDWADFAHEIPGEKIS-L 526
            .|:::...:.....:|.||.:|:.||.||.|...||..|.||.|.:.....:....:..:.:: .
Human   532 GELRNKLFQPTHRIHGFDLAAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKK 596

  Fly   527 LRRLYATPDDVELGVGGTLEYHVPDALFGPTLLCVIGKQFLNTRRGDRFFFERENEGGFSRAQLA 591
            |..||.|||::::.:|...|..|.....||.|.|::||||...|.||||::  ||.|.|:..|..
Human   597 LLGLYGTPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWW--ENPGVFTNEQKD 659

  Fly   592 EIRKVSLSSLFCSNANYLHLIQPNVFVFPNSHNL-LLNCNFIPQIDLSKWQDLR 644
            .::|:|.|.|.|.|.....:  |....:.||:.. .::|:.|.::|||.|..::
Human   660 SLQKMSFSRLVCDNTRITKV--PRDPFWANSYPYDFVDCSAIDKLDLSPWASVK 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4009	NP_001262655.1	An_peroxidase_like	77..>367	CDD:265428	98/328 (30%)
		An_peroxidase	95..610	CDD:281139	165/572 (29%)
		peroxinectin_like	228..605	CDD:188655	117/405 (29%)
LPO	NP_006142.1	An_peroxidase	138..674	CDD:281139	164/568 (29%)
LPO	NP_006142.1	myeloperoxidase_like	283..694	CDD:188656	123/440 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150048
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750