Protein Alignment CG4009 and Tpo

DIOPT Version :10

• Sequence 1: NP_650588.2
• Gene: CG4009 / 42054
• FlyBaseID: FBgn0038469
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_011242158.1
• Gene: Tpo / 22018
• MGIID: 98813
• Length: 915
• Species: Mus musculus
• Alignment Length: 733
• Identity: 216/733 - (29%)
• Similarity: 314/733 - (42%)
• Gaps: 166/733 - (22%)

  Fly     7 VLSVLSVAVATKCPYSA----------MEPSLSRSKRSSFDIRPGVSDGSLDALIKEFMPKYNGN 61
            |||...:....|.|.|.          ||.|:...||..       |..|.|||..:.:    |.
Mouse    67 VLSPAQLLSFFKLPESTSGAISRAAEIMETSIQVMKREQ-------SQFSTDALSADIL----GT 120

  Fly    62 NVHNSWAEPSASQQPLRCGVPPRNCLNDTRNLHYRTLDGSCNNLLYPEFGIAVSRYRRLLPP--- 123
            ..:.|...|  ...|.||   |..||.:    .||.:.|:|||..:|.:|.:.:...|.|||
Mouse   121 IANLSGCLP--FMLPPRC---PDTCLAN----KYRPITGACNNRDHPRWGASNTALARWLPPVYE 176

  Fly   124 -----------------------RQVEQAPNARLISLSLYGEQ-TRNDRFRTMAAMQWGQFVAHD 164
                                   |:|.:    .||.:|  .|. |.:|::.....: |||::.||
Mouse   177 DGFSQPKGWNPNFLYHGFPLPPVREVTR----HLIQVS--NEAVTEDDQYSDFLPV-WGQYIDHD 234

  Fly   165 ISQLSTQGAPQ-------DC--CAEPRHPRCLPINLPRGGPIAYHTGKT-CLHFARS-----VSD 214
            |: |:.|....       ||  ..|.::| |.||.||...     :|.| ||.|.||     ..|
Mouse   235 IA-LTPQSTSTAAFWGGVDCQLTCENQNP-CFPIQLPSNS-----SGTTACLPFYRSSAACGTGD 292

  Fly   215 ADAICPKVEEPQP-EKLTVATAYLDLSSIYGNNPSQNRKVRLF--KGGLLKTSYTN---GQHWLP 273
            ..|:...:....| :::...|::||.|::||::|...:::|.:  ..|||:.:..:   |:.:||
Mouse   293 QGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDAGRAYLP 357

  Fly   274 VSQNENGECGA--------KSECYIVPDIRNRFSPTIALLQTLLVREHNRLAENLALINPDHSDE 330
            .:   ...|..        ::.|::..|.|....|.:|.:.||.:|||||||.....||...|..
Mouse   358 FA---TAACAPEPGTPRTNRTPCFLAGDGRASEVPALAAVHTLWLREHNRLASAFKAINKHWSAN 419

  Fly   331 RIFQEARKINIAQFQKITYYDWLPLFVG----RTYTYLNGLIYPVEPTEYVNDYDETVNPAAYAE 391
            ..:|||||:..|..|.||..|::|..:|    |.|         |.|.|   .|:.||||.....
Mouse   420 TAYQEARKVVGALHQIITMRDYIPKILGPDAFRQY---------VGPYE---GYNPTVNPTVSNI 472

  Fly   392 FSAAAFRYAHTQIPGWFSLVAPNRRSNRTMRLSDFLDRTETIRL-----------LDTSDNFDAL 445
            ||.||||:.|..:   ..||   ||.|     :||.:.||..||           |......|.:
Mouse   473 FSTAAFRFGHATV---HPLV---RRLN-----TDFQEHTELPRLQLRDVFFRPWRLIQEGGLDPI 526

  Fly   446 LRGLATQLHKRSDGNIDREIKHYFNRKEFEE-------YGS-DLKSIDIQRARDFGLASYNDVRE 502
            :|||..:..|       .:::.....:|..|       .|: ||.|:::||.||.||..||:.||
Mouse   527 VRGLLARAAK-------LQVQGQLMNEELTERLFVLSNVGTLDLASLNLQRGRDHGLPDYNEWRE 584

  Fly   503 FCGLRRAVDWADFAHEIPGEK-ISLLRRLYATPDDVELGVGGTLEYHVPDALFGPTLLCVIGKQF 566
            ||||.|....|:....|.... ::.:..||...|::::.:||..|..:|.|..||...|:||||.
Mouse   585 FCGLSRLETPAELNKAIANRSMVNKIMDLYKHADNIDVWLGGLAEKFLPGARTGPLFACIIGKQM 649

  Fly   567 LNTRRGDRFFFERENEGGFSRAQLAEIRKVSLSSLFCSNANYLHLIQPNVF---VFPNSHNLLLN 628
            ...|.||||::|..|.  |:.||..|:.|.||..:.|.|.. |..:..:.|   .||....   :
Mouse   650 KALRDGDRFWWENTNV--FTDAQRQELEKHSLPRVICDNTG-LTRVPVDAFRIGKFPQDFE---S 708

  Fly   629 CNFIPQIDLSKWQDLRPQ 646
            |..||.:||..|::..||
Mouse   709 CEDIPSMDLELWRETFPQ 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4009	NP_650588.2	An_peroxidase	95..617	CDD:460804	180/601 (30%)
Tpo	XP_011242158.1	thyroid_peroxidase	161..722	CDD:188657	182/613 (30%)
		CCP	730..783	CDD:153056
		EGF_CA	784..813	CDD:429571