DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4009 and K10B4.1

DIOPT Version :9

Sequence 1:	NP_001262655.1	Gene:	CG4009 / 42054	FlyBaseID:	FBgn0038469	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_493669.2	Gene:	K10B4.1 / 187249	WormBaseID:	WBGene00019613	Length:	1294	Species:	Caenorhabditis elegans

Alignment Length:	632	Identity:	187/632 - (29%)
Similarity:	313/632 - (49%)	Gaps:	87/632 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 NVHNSWAEPSASQQPLRCGVPPRNCLNDTRNLHYRTLDGSCNNLLYPEFGIAVSRYRRLLPPRQV 126
            |:...:.:.|.||    |.  |:|...|:.| .||:..|.||||..|.........||||||...
Worm   636 NIGEDFGKKSDSQ----CN--PKNLPCDSTN-PYRSYTGWCNNLETPSLANTFRELRRLLPPAYE 693

  Fly   127 E-------------QAPNARLISLSLYG----EQTRNDRFRTMAAMQWGQFVAHDIS----QLST 170
            :             :.|:.|:||..::.    |..:...|    .|::|||:.|||:    ..::
Worm   694 DGIDLPRSKTITGSRLPSPRVISNMVHHAKKIEHVKYSHF----VMEFGQFIDHDITHSPVDQNS 754

  Fly   171 QGAPQDC--CAEPR--HPRCLPINLPRGGPIAYHTGKTCLHFARSVSDADAICPKVEEPQPEKLT 231
            .|...:|  |...|  .|.|.||.:|...  .:....:||.|.||:.....:..:      .::.
Worm   755 DGTALNCSRCDSGRFVSPSCFPIPVPVND--VHFEPFSCLSFVRSLPAQKTLGYR------NQMN 811

  Fly   232 VATAYLDLSSIYGNNPSQNRKVRLFKGGLLKTSYTN--GQHW-LPVSQNENGE---C--GAKSEC 288
            ..:||||.|.:||:...:..::|.|:.|.:||:.|:  .:|: :.:||::..|   |  ...:.|
Worm   812 QVSAYLDGSVMYGSTKCEGDRLRTFQDGKMKTTQTSRAPRHYGITLSQSDESEQDGCVSAPDAPC 876

  Fly   289 YIVPDIRNRFSPTIALLQTLLVREHNRLAENLALINPDHSDERIFQEARKINIAQFQKITYYDWL 353
            :|..|.||.....:..:.::..|||.|:...|..|||:..||:|:||.||:..|:|..|.|.::|
Worm   877 FIAGDDRNSQQTLLIAVHSVFHREHERITTTLKEINPNWDDEKIYQETRKLISAEFAHIVYNEYL 941

  Fly   354 PLFVGRTYTYLNGLI--YPVEPTE--YVNDYDETVNPAAYAEFSAAAFRYAHTQIPGWFSLVAPN 414
            |:.:|:.      ||  |.:.|.:  |.:.| |..:.:....|:.||||:.|:.:..:..:
Worm   942 PIIIGQK------LIDDYDLRPRQDGYYDGY-ENCDASILQPFATAAFRFGHSTVTRFTPM---- 995

  Fly   415 RRSNRTMR---------LSDFLDRTETIRLLDTSDNFDALLRGLATQLHKRSDGNIDREIKHY-F 469
               ..|:.         .||||:.:   ::.| ::..:.:|.|:..:....:|..:|..|::: |
Worm   996 ---QETVHDPATCVVDLASDFLNMS---KIYD-NEAVEQILGGMHGKHQMMTDRFVDDAIRNFLF 1053

  Fly   470 NRKEFEEYGSDLKSIDIQRARDFGLASYNDVREFCGLRRAVDWADFAHEIPGEKISLLRRLYATP 534
            :.:.....|.||.||:|||.||.|:..||..|.||||.|...:.....:|..:.::.:.::|.:|
Worm  1054 SDRGRRGTGLDLISINIQRGRDHGIPPYNHYRSFCGLSRLTSFYSIFSDINQDGLTAIGKVYESP 1118

  Fly   535 DDVELGVGGTLEYHVPDALFGPTLLCVIGKQFLNTRRGDRFFFER-ENEGGFSRAQLAEIRKVSL 598
            ||::|..|...|..:|..:.|||..|:|.:||...::.|||::|. |:...||.:||.|:||.|:
Worm  1119 DDIDLFTGIVSEKTIPGGIVGPTAACIIAEQFRRLKKCDRFYYENGEDHSKFSASQLKEVRKTSM 1183

  Fly   599 SSLFCSNANYLHLIQPNVFVFPNS-HNLLLNCNFIPQIDLSKWQDLR 644
            |:|.|:|.. :..|..:||..|:. .|.|:||:..|::|||||:|.:
Worm  1184 SALICANTK-VPKISKDVFSVPDPFSNPLINCDLYPKLDLSKWRDAK 1229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4009	NP_001262655.1	An_peroxidase_like	77..>367	CDD:265428	91/322 (28%)
		An_peroxidase	95..610	CDD:281139	163/562 (29%)
		peroxinectin_like	228..605	CDD:188655	121/399 (30%)
K10B4.1	NP_493669.2	An_peroxidase	93..509	CDD:281139
		An_peroxidase_like	94..>321	CDD:265428
		An_peroxidase_like	224..508	CDD:265428
		An_peroxidase	662..1191	CDD:281139	162/558 (29%)
		peroxinectin_like	807..1190	CDD:188655	121/406 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11475
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920