DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4009 and duox-2

DIOPT Version :9

Sequence 1:	NP_001262655.1	Gene:	CG4009 / 42054	FlyBaseID:	FBgn0038469	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_490684.1	Gene:	duox-2 / 186188	WormBaseID:	WBGene00018771	Length:	1503	Species:	Caenorhabditis elegans

Alignment Length:	602	Identity:	163/602 - (27%)
Similarity:	249/602 - (41%)	Gaps:	106/602 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 DGSCNNLLYPEFGIAVSRYRRLLPPRQV---------EQAPNARLISLSLY-GEQ-TRNDRFRTM 152
            ||..|||...|:|.|.||..|  ..|..         ...|:||.:|..|: ||. ..|.|..|.
Worm    42 DGWYNNLANSEWGSAGSRLHR--DARSYYSDGVYSVNNSLPSARELSDILFKGESGIPNTRGCTT 104

  Fly   153 AAMQWGQFVAHDISQLSTQGAPQDCCAEPRHPRCLPINLPRGGPIAYH--TGKTCLHFARSVSDA 215
            ....:.|.||::|.|.:....|.:         .|.|.:|....:..:  .|||.:.|.|:..|
Worm   105 LLAFFSQVVAYEIMQSNGVSCPLE---------TLKIQVPLCDNVFDNECEGKTTIPFYRAKYD- 159

  Fly   216 DAICPKVEEPQPEKLTVATAYLDLSSIYGNNPSQNRKVRLFKGGLLKTSY-----TNGQHWLPVS 275
            .|....:..|: |::...|:::|.|.|||........:|.||.|.|....     .|..| :|::
Worm   160 KATGNGLNSPR-EQINERTSWIDGSFIYGTTQPWVSALRSFKQGRLAEGVPGYPPLNNPH-IPLN 222

  Fly   276 QNENGECG---AKSECYIVPDIRNRFSPTIALLQTLLVREHNRLAENLALINPDHSDERIFQEAR 337
            .....:..   :....:::.|.|...:|.:.....:|.|.||..|..:...:||.:||:|||.||
Worm   223 NPAPPQVHRLMSPDRLFMLGDSRVNENPGLLSFGLILFRWHNYNANQIYREHPDWTDEQIFQAAR 287

  Fly   338 KINIAQFQKITYYDWLPLFVGRTYTYLNGLIYPVEPTEYVNDYDETVNPAAYAEFSAAAFRYAHT 402
            ::.||..|||..||::|..:|.          .|..:.|.. |...|.|.....|.|||||:.|:
Worm   288 RLVIASMQKIIAYDFVPGLLGE----------DVRLSNYTK-YMPHVPPGISHAFGAAAFRFPHS 341

  Fly   403 QIPGWFSLVAPNRRSNRTMRLSDFLDRTE-----TIRLLDTSDN---------FDALLRGLATQL 453
            .:|....|   .:|.|:    .:|  |||     .:||.....|         .|.::.|:|:|:
Worm   342 IVPPAMLL---RKRGNK----CEF--RTEVGGYPALRLCQNWWNAQDIVKEYSVDEIILGMASQI 397

  Fly   454 HKRSDGNIDREIKHY-FNRKEFEEYGSDLKSIDIQRARDFGLASYNDVREFCGLRRAVDW----A 513
            .:|.|..:..:::.| |....|...  |:.:..|.|.||.|:..||::|...||.... |    .
Worm   398 AERDDNIVVEDLRDYIFGPMHFSRL--DVVASSIMRGRDNGVPPYNELRRTFGLAPKT-WETMNE 459

  Fly   514 DF--AHEIPGEKISLL---RRLYATPDDVELGVGGTLE--YHVPDALFGPTLLCVIGKQFLNTRR 571
            ||  .|....||:..|   ..||     ::..|||.||  .:.|..:|..    :|..||...|.
Worm   460 DFYKKHTAKVEKLKELYGGNILY-----LDAYVGGMLEGGENGPGEMFKE----IIKDQFTRIRD 515

  Fly   572 GDRFFFERENEGGFSRAQLAEIRKVSLSSLFCSNANYLH-LIQPNVFVF----PNSHNLLLN--- 628
            ||||:||.:....|:..::..|..::|..:..:..:... ::|.:||.|    |......:|
Worm   516 GDRFWFENKLNRLFTDEEVQMIHSITLRDIIKATTDIDETMLQKDVFFFKEGDPCPQPFQVNTIG 580

  Fly   629 ---CNFIPQIDLSKWQD 642
               |  .|.|..:.|.|
Worm   581 LEPC--APLIQSTYWDD 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4009	NP_001262655.1	An_peroxidase_like	77..>367	CDD:265428	80/288 (28%)
		An_peroxidase	95..610	CDD:281139	152/557 (27%)
		peroxinectin_like	228..605	CDD:188655	113/410 (28%)
duox-2	NP_490684.1	An_peroxidase	39..552	CDD:281139	152/555 (27%)
		dual_peroxidase_like	41..596	CDD:188652	163/602 (27%)
		FRQ1	792..>895	CDD:227455
		Ferric_reduct	1041..1182	CDD:280043
		NOX_Duox_like_FAD_NADP	1224..1408	CDD:99783
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910