DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4009 and C46A5.4

DIOPT Version :9

Sequence 1:	NP_001262655.1	Gene:	CG4009 / 42054	FlyBaseID:	FBgn0038469	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_501272.2	Gene:	C46A5.4 / 177558	WormBaseID:	WBGene00016700	Length:	1537	Species:	Caenorhabditis elegans

Alignment Length:	697	Identity:	209/697 - (29%)
Similarity:	336/697 - (48%)	Gaps:	88/697 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LSVAVATKCPYSAMEPSLSRS-KRSSFDIRPG-----------VSDGSLD----------ALIKE 53
            :|..::...|.:.:..:|..: |:.|.||...           :|...||          ..:::
Worm   789 ISAQLSDSSPSALLSHALLMAPKKESIDIARTASVLREATNILISGNGLDKDERLPDLDIGTLQK 853

  Fly    54 FMPKYNGNNVHNSWAEPSASQQPLRCGVPPRNCLND----TRNLHYRTLDGSCNNLLYPEFGIAV 114
            .:|:.:..:|..::. |..::.||    |...||.:    .....|||..|.||||..|:||.|.
Worm   854 ILPQIDVGSVIGNFT-PFLARDPL----PKEQCLPEPLPCDHTSKYRTYSGWCNNLKNPKFGNAF 913

  Fly   115 SRYRRLLPP-----------RQV--EQAPNARLISLSLYGEQTRNDRFRTMAAMQWGQFVAHDIS 166
            ::.||||.|           |.|  .:.|:||.||..::.:..:.....|...||:||.:.||:.
Worm   914 TQMRRLLDPAYDDGFDTPRTRSVLGSELPSARKISNIVHSDAPKFHVKFTHMLMQFGQILDHDMM 978

  Fly   167 QLSTQGAPQ----DC--C--AEPRHPRCLPINLPRGGPI---AYHTGK-TCLHFARSVSDADAIC 219
            .......|:    :|  |  |:.....|.||.:....|.   .:..|: .|:.||||      :.
Worm   979 HSPISRGPKNTILNCSSCDSAQTLSIHCFPIKIEANDPFFPSKHSDGRPRCMPFARS------LL 1037

  Fly   220 PKVEEPQPEKLTVATAYLDLSSIYGNNPSQNRKVRLFKGGLLKTSYTN---GQHWLPVSQNENGE 281
            .:|......:|...|::||.|:|||:...:..|:|||..|  |.::|:   .:..|| ..|:..:
Worm  1038 AQVSLGFRNQLNQLTSFLDASTIYGSTQCEANKLRLFSDG--KLNFTDLGFNKEALP-QGNQERD 1099

  Fly   282 C-----GAKSECYIVPDIRNRFSPTIALLQTLLVREHNRLAENLALINPDHSDERIFQEARKINI 341
            |     ..:..|::..|.|:...|.:..:..:.:|||||:|..|..||...|||::|||:|:|||
Worm  1100 CRSVLQNRQRRCFVAGDERSNEQPGLTAIHNIFLREHNRIARYLKQINNFWSDEKLFQESRRINI 1164

  Fly   342 AQFQKITYYDWLPLFVGRTYTYLNGLIYPVEPTEYVNDYDETVNPAAYAEFSAAAFRYAHTQIPG 406
            ||.|.|.|.:|||:.:|.......||:  .:...|...||:..:.....|.|.:|||:.|:.|.|
Worm  1165 AQLQHIIYKEWLPVVLGCQNMEKWGLM--PQTAGYFEGYDDQCDATISQEMSTSAFRFGHSLIRG 1227

  Fly   407 WFSLVAPNRRSNRTMRLSDFLDRTETIR----LLD-TSDNFDALLRGLATQLHKRSDGNIDREIK 466
            .|:     |.::....:::.::.|||..    :.| .|.:.:::|.||........|.:|...::
Worm  1228 VFT-----RMNDNFQNMTNHVNLTETFSNPSPVYDKNSGHMESILMGLIGANSMAFDRHIVTAVR 1287

  Fly   467 -HYFNRKEFEEYGSDLKSIDIQRARDFGLASYNDVREFCGLRRAVDWADFAHEIPGEKISLLRRL 530
             |.|.:......|.||.:::|||.||.|:..||..|:.||||:|..::|....:..|.::.|...
Worm  1288 NHLFAKPGGPLTGLDLPAVNIQRGRDHGVQGYNAYRKHCGLRKASAFSDLRDVMNSEAVTALETA 1352

  Fly   531 YATPDDVELGVGGTLEYHVPDALFGPTLLCVIGKQFLNTRRGDRFFFE-RENEGGFSRAQLAEIR 594
            ||..||::|..|...|.....:|.||||.|:||:|....::.|||::| .::...|:..||.|||
Worm  1353 YAHVDDIDLFPGIMSESPTRGSLVGPTLACLIGEQMQRLKKCDRFYYETSDSMVRFTPDQLVEIR 1417

  Fly   595 KVSLSSLFCSNANYLHLIQPNVFVFPNS-HNLLLNCNFIPQIDLSKW 640
            |.|||.:.|.|:.|...||||||:.|:. .|..:.|:.:.:|||:||
Worm  1418 KASLSRIICDNSEYAANIQPNVFLMPDDLTNSPMTCSELSEIDLNKW 1464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4009	NP_001262655.1	An_peroxidase_like	77..>367	CDD:265428	101/326 (31%)
		An_peroxidase	95..610	CDD:281139	177/554 (32%)
		peroxinectin_like	228..605	CDD:188655	129/391 (33%)
C46A5.4	NP_501272.2	An_peroxidase	182..717	CDD:281139
		peroxinectin_like	334..712	CDD:188655
		An_peroxidase	894..1429	CDD:281139	175/550 (32%)
		peroxinectin_like	1045..1428	CDD:188655	129/392 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7941
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11475
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.870