DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4009 and tpo

DIOPT Version :9

Sequence 1:	NP_001262655.1	Gene:	CG4009 / 42054	FlyBaseID:	FBgn0038469	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_031758614.1	Gene:	tpo / 100036738	XenbaseID:	XB-GENE-920152	Length:	872	Species:	Xenopus tropicalis

Alignment Length:	693	Identity:	195/693 - (28%)
Similarity:	312/693 - (45%)	Gaps:	123/693 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PYSAMEPSLSRSKRSSFDIRPGVSDGSLDALIKEFMPKYNGNNVHNSWAEPSASQQPLRCGVPPR 84
            |.||:..:.|::.::|.:..|...|.|           :.|::.....|..:...........|.
Frog    40 PQSALPRNSSQTDKTSLEQHPESEDVS-----------HTGSSFEAVLANLTGCVPQTLSPFCPN 93

  Fly    85 NCLNDTRNLHYRTLDGSCNNLLYPEFGIAVSRYRRLLPPR-----------------------QV 126
            |||..    .||.:.|:|||...|.:|.|.:...|.||.:                       ||
Frog    94 NCLAG----KYRHITGACNNRNNPAWGAANTLLARWLPAQYEDGIGEPKGWREEFLYNGFRLPQV 154

  Fly   127 EQAPNARLISLSLYGEQTRNDRFRTMAAMQWGQFVAHDI--SQLSTQGAPQ----DC--CAEPRH 183
            .:..| ::|..|  .:..|.|...:...::|||::.|||  :..|....|.    ||  ..|..:
Frog   155 REVTN-KIIHAS--SKAFREDDLYSHIIIEWGQYIDHDIAFTPQSVSKTPAIGSVDCKSTCENLY 216

  Fly   184 PRCLPINLPRGGPIAYHTGKTCLHFARSVSDADAIC-----------PKVEEPQPEKLTVATAYL 237
            | |.||.|....|::.   ..|:.|.||.|    .|           |.:..|: |::...|:::
Frog   217 P-CYPIKLSEEDPLSQ---GGCIPFYRSSS----ACGTGRGGLKFGNPSLLNPR-EQINGLTSFI 272

  Fly   238 DLSSIYGNNPSQNRKVRLFKG--GLLKTS--YT-NGQHWLPVS------QNENGECGAKSECYIV 291
            |.|::||::.|...|::....  |||:.:  |: :.:.:||..      |:...:...:.:|:..
Frog   273 DASTVYGSSESLQHKLKNLSSEEGLLRVNVKYSDSSREYLPFETPSACMQDPTADNAERIDCFFA 337

  Fly   292 PDIRNRFSPTIALLQTLLVREHNRLAENLALINPDHSDERIFQEARKINIAQFQKITYYDWLPLF 356
            .:.|.....|:|.:.||.:|||||:|:.|..:||..:.|..:||||||..|..|.||:.|::|..
Frog   338 GEGRANEVITLAAVHTLWLREHNRIAKALKKLNPHWNSETTYQEARKIVGALHQIITFRDYMPKI 402

  Fly   357 VGR-TYTYLNGLIYPVEPTEYVNDYDETVNPAAYAEFSAAAFRYAHTQIPGWFSLVAPNRRSNRT 420
            :|: .|....||         ...|::..||:....|:.||||:.|..||...      .|.|
Frog   403 LGKAAYDQYIGL---------YKGYNQKTNPSISNIFTTAAFRFGHATIPPMV------HRLN-- 450

  Fly   421 MRLSDFLDRTETIRL-----------LDTSDNFDALLRGL---ATQLHKRSDGNIDREIKHYFNR 471
               |.::|..:...|           :......|.|:|||   :.:|..:.| .|:.|:..  ..
Frog   451 ---SQYVDDPKYPSLPLNEVFFRPWRIVKEGGLDPLIRGLLGKSAKLQTQVD-MINEELTE--KL 509

  Fly   472 KEFEEYGS-DLKSIDIQRARDFGLASYNDVREFCGLRRAVDWADFAHEIPGEK-ISLLRRLYATP 534
            ......|| ||.|:::||.||.||..|||.||||||.|....||..:.:..:| ::.:..||:.|
Frog   510 LVMTNNGSMDLASLNLQRGRDHGLPGYNDWREFCGLSRLATPADLINAVSDQKLVAKMIALYSHP 574

  Fly   535 DDVELGVGGTLEYHVPDALFGPTLLCVIGKQFLNTRRGDRFFFERENEGGFSRAQLAEIRKVSLS 599
            |::::.:||..|..:|.|..||...|:||||....|.||||::|..|.  |::.|.:|:.|.|||
Frog   575 DNIDVWLGGLAEDFLPGARTGPLFACLIGKQMQALREGDRFWYENNNI--FTKIQRSELEKHSLS 637

  Fly   600 SLFCSNANYLHLIQPNVFVFPNSHNLLLNCNFIPQIDLSKWQD 642
            .:.|.|....| :..:.|:..|..:..::|:.||.|:|..|::
Frog   638 RVICDNTGLSH-VPLDAFLLGNYPDNFVSCDSIPGINLEAWKE 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4009	NP_001262655.1	An_peroxidase_like	77..>367	CDD:265428	93/343 (27%)
		An_peroxidase	95..610	CDD:281139	172/584 (29%)
		peroxinectin_like	228..605	CDD:188655	127/404 (31%)
tpo	XP_031758614.1	thyroid_peroxidase	116..679	CDD:188657	174/600 (29%)
		CCP	687..736	CDD:153056
		EGF_CA	738..781	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010