DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdSL and ADE13

DIOPT Version :9

Sequence 1:	NP_650586.2	Gene:	AdSL / 42051	FlyBaseID:	FBgn0038467	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_013463.1	Gene:	ADE13 / 851073	SGDID:	S000004351	Length:	482	Species:	Saccharomyces cerevisiae

Alignment Length:	481	Identity:	281/481 - (58%)
Similarity:	362/481 - (75%)	Gaps:	4/481 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NYEGYKSPLSTRYASKEMQFLFSDQNKFSTWRRLWVWLAKAESRLGLE-ISDAQIAEM--ELQIS 65
            :|:.|.:|||:|||||||...||.:|:|||||:||:.||.||..|||. ::|..|.:|  .::|:
Yeast     3 DYDNYTTPLSSRYASKEMSATFSLRNRFSTWRKLWLNLAIAEKELGLTVVTDEAIEQMRKHVEIT 67

  Fly    66 NIDFEAAAAEERLTRHDVMAHVHVFAKQCPSAAPVIHLGATSCYVGDNTDLIVLRDALKLLLPRV 130
            :.:...|:|:|.:.|||||||||.|.:.||:||.:||||||||:|.||.|||.:|||..:::|::
Yeast    68 DDEIAKASAQEAIVRHDVMAHVHTFGETCPAAAGIIHLGATSCFVTDNADLIFIRDAYDIIIPKL 132

  Fly   131 ASVIARLSQFAQSYKDQPTLGFTHLQPAQLTTVGKRACLWIQDLIMDERALSRCLEDLRFRGVKG 195
            .:||.||::||..|||.|.||:||.|||||||:||||.||||:|:.|.|...|...|:..|||||
Yeast   133 VNVINRLAKFAMEYKDLPVLGWTHFQPAQLTTLGKRATLWIQELLWDLRNFERARNDIGLRGVKG 197

  Fly   196 TTGTQASFLQLFNGDGEKVKQLDQLVTELAGFKKAYAVTGQTYSRKVDVEIVAALASLGTTIHKM 260
            |||||||||.||:|:.:||:.||:.||||.||.|.|.|||||||||:|::::|.|:|...|.|||
Yeast   198 TTGTQASFLALFHGNHDKVEALDERVTELLGFDKVYPVTGQTYSRKIDIDVLAPLSSFAATAHKM 262

  Fly   261 CSDLRILASRKELEEPFESTQIGSSAMPYKRNPMRSERCCALARHLITLFSSAANTHATQWLERT 325
            .:|:|:||:.||:|||||.:|||||||.|||||||.||.|:|||||.:|||.|..|.:.||.|||
Yeast   263 ATDIRLLANLKEVEEPFEKSQIGSSAMAYKRNPMRCERVCSLARHLGSLFSDAVQTASVQWFERT 327

  Fly   326 LDDSANRRLTLSEAFLAADAALLTLLNISQGLVVYPKVIERHISQELPFMSTENIIMAMVKAGGD 390
            |||||.||::|..|||.||..|.||||||.|||||||||||.|..|||||:|||||||||:....
Yeast   328 LDDSAIRRISLPSAFLTADILLSTLLNISSGLVVYPKVIERRIKGELPFMATENIIMAMVEKNAS 392

  Fly   391 RQVCHEKIRVLSQEAGAQVKQHGKDNDLVVRVRKDPYFSPILEQLDTILDAKTFTGRASDQVGEF 455
            ||..||:|||||.:|.|.||:.|.:|||:.||::|.:|.||.|:||::|:..||.|||..||.:|
Yeast   393 RQEVHERIRVLSHQAAAVVKEEGGENDLIERVKRDEFFKPIWEELDSLLEPSTFVGRAPQQVEKF 457

  Fly   456 VKEEVEPVLARYSEALKNVQDVKLNI 481
            |:::|...|..:.:.| |.:.||||:
Yeast   458 VQKDVNNALQPFQKYL-NDEQVKLNV 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdSL	NP_650586.2	PurB	12..458	CDD:223094	270/448 (60%)
AdSL	NP_650586.2	Adenylsuccinate_lyase_2	12..447	CDD:176471	263/437 (60%)
ADE13	NP_013463.1	Adenylsuccinate_lyase_2	11..449	CDD:176471	263/437 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346586
Domainoid	1	1.000	272	1.000	Domainoid score	I278
eggNOG	1	0.900	-	-		E1_COG0015
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12
Inparanoid	1	1.050	554	1.000	Inparanoid score	I165
Isobase	1	0.950	-	0	Normalized mean entropy	S248
OMA	1	1.010	-	-		QHG60641
OrthoFinder	1	1.000	-	-		FOG0004771
OrthoInspector	1	1.000	-	-		oto99569
orthoMCL	1	0.900	-	-		OOG6_100666
Panther	1	1.100	-	-	LDO	PTHR43172
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2248
SonicParanoid	1	1.000	-	-		X3924
TreeFam	1	0.960	-	-
	16	15.740