DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdSL and adsl

DIOPT Version :9

Sequence 1:	NP_650586.2	Gene:	AdSL / 42051	FlyBaseID:	FBgn0038467	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_956193.2	Gene:	adsl / 334431	ZFINID:	ZDB-GENE-030131-6363	Length:	482	Species:	Danio rerio

Alignment Length:	474	Identity:	327/474 - (68%)
Similarity:	388/474 - (81%)	Gaps:	4/474 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YKSPLSTRYASKEMQFLFSDQNKFSTWRRLWVWLAKAESRLGLEISDAQIAEMELQISNIDFEAA 72
            |:|||.:|||||||.:.|||:.||:|||:||::|||||..|||.|||||::|||....:|||..|
Zfish    11 YRSPLVSRYASKEMAYNFSDRKKFTTWRKLWIYLAKAEKSLGLPISDAQVSEMESHSEDIDFVMA 75

  Fly    73 AAEERLTRHDVMAHVHVFAKQCPSAAPVIHLGATSCYVGDNTDLIVLRDALKLLLPRVASVIARL 137
            |.|||..|||||||||.||:.||:|||:|||||||||||||||||:|||...:|||::|.||.||
Zfish    76 AEEERKLRHDVMAHVHTFAQCCPTAAPIIHLGATSCYVGDNTDLIMLRDGFDILLPKLARVIDRL 140

  Fly   138 SQFAQSYKDQPTLGFTHLQPAQLTTVGKRACLWIQDLIMDERALSRCLEDLRFRGVKGTTGTQAS 202
            :.||:.|.|..||||||.|||||||||||:|||:|||:||.|.|.|..:||||||||||||||||
Zfish   141 ANFAEKYADLTTLGFTHYQPAQLTTVGKRSCLWLQDLLMDMRNLQRARDDLRFRGVKGTTGTQAS 205

  Fly   203 FLQLFNGDGEKVKQLDQLVTELAGFKKAYAVTGQTYSRKVDVEIVAALASLGTTIHKMCSDLRIL 267
            |||||.||.:||::||::|||:|||||:|.|||||||||||::.:..|:||..||||:|:|:|:|
Zfish   206 FLQLFQGDHDKVEELDKMVTEMAGFKKSYLVTGQTYSRKVDIDSLCVLSSLAATIHKICTDIRLL 270

  Fly   268 ASRKELEEPFESTQIGSSAMPYKRNPMRSERCCALARHLITLFSSAANTHATQWLERTLDDSANR 332
            |:.||:|||||..|||||||||||||||:||||:|||||:.|.|:...|.|.|||||||||||||
Zfish   271 ANLKEIEEPFEKEQIGSSAMPYKRNPMRAERCCSLARHLMALVSNPLQTAAVQWLERTLDDSANR 335

  Fly   333 RLTLSEAFLAADAALLTLLNISQGLVVYPKVIERHISQELPFMSTENIIMAMVKAGGDRQVCHEK 397
            |::|.||||.||..|.||.||::|||||||||||||..|||||:|||||||||||||:||.||||
Zfish   336 RISLPEAFLTADIILSTLQNITEGLVVYPKVIERHIRHELPFMATENIIMAMVKAGGNRQDCHEK 400

  Fly   398 IRVLSQEAGAQVKQHGKDNDLVVRVRKDPYFSPILEQLDTILDAKTFTGRASDQVGEFVKEEVEP 462
            ||||||:|.|.|||.|.||||:.||:.||||:|||.:||.:||.|||.|||..||..|:.|||.|
Zfish   401 IRVLSQQAAAVVKQEGGDNDLLARVQADPYFAPILGELDALLDPKTFIGRAPQQVTRFLSEEVRP 465

  Fly   463 VLARYSEALKNVQDVKLNI 481
            ||..|    |:..|||:.:
Zfish   466 VLEPY----KSKMDVKIEL 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdSL	NP_650586.2	PurB	12..458	CDD:223094	313/445 (70%)
AdSL	NP_650586.2	Adenylsuccinate_lyase_2	12..447	CDD:176471	307/434 (71%)
adsl	NP_956193.2	purB	15..458	CDD:273345	312/442 (71%)
adsl	NP_956193.2	Adenylsuccinate_lyase_2	15..450	CDD:176471	307/434 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596181
Domainoid	1	1.000	305	1.000	Domainoid score	I1344
eggNOG	1	0.900	-	-		E1_COG0015
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12
Inparanoid	1	1.050	654	1.000	Inparanoid score	I763
OMA	1	1.010	-	-		QHG60641
OrthoDB	1	1.010	-	-		D268338at33208
OrthoFinder	1	1.000	-	-		FOG0004771
OrthoInspector	1	1.000	-	-		oto40933
orthoMCL	1	0.900	-	-		OOG6_100666
Panther	1	1.100	-	-	LDO	PTHR43172
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2248
SonicParanoid	1	1.000	-	-		X3924
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800