DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdSL and SPBC8E4.05c

DIOPT Version :9

Sequence 1:	NP_650586.2	Gene:	AdSL / 42051	FlyBaseID:	FBgn0038467	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_596842.1	Gene:	SPBC8E4.05c / 2541238	PomBaseID:	SPBC8E4.05c	Length:	447	Species:	Schizosaccharomyces pombe

Alignment Length:	456	Identity:	105/456 - (23%)
Similarity:	186/456 - (40%)	Gaps:	58/456 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YASKEMQFLFSDQNKFSTWRRLWVWLAKAESRLGLEISDAQIAEMELQ----ISNIDFEAAAAEE 76
            :...|::.::||:|:...:......||:||:.||:   ..:.|..|:|    :.||||.....|.
pombe    15 FGDAEIRKIWSDENRTQEYLNWEAALARAEASLGI---IPKYAGEEIQRVCKVENIDFSKLEEET 76

  Fly    77 RLTRHDVMAHVHVFAKQCP-SAAPVIHLGATSCYVGDNTDLIVLRDALKLLLPRVASVIARLSQF 140
            ....:.|:..||..|..|. .:....|.|||:..|.|:..:..:.|:.|::...:...|...:..
pombe    77 INIGYPVLGVVHQLANLCSGDSGKYCHWGATTQDVTDSATVRQMIDSFKIIKGYLEKAIELATVL 141

  Fly   141 AQSYKDQPTLGFTHLQPAQLTTVGKRACLWIQDLIMDERALSRCLEDLRFRGVKGTTGTQASFLQ 205
            ...:::....|.::||.|...|.|.:...::..|....:.|...|..:......|..||.||
pombe   142 VIKHRETTMAGRSNLQQAVPITFGFKMARFVATLRRHHQRLCELLPRVSVLEFGGACGTLAS--- 203

  Fly   206 LFNGDGEKVKQLDQLVTELAGFKKAYAVTGQTYSRKVDVEIVAALASLGTTIHKMCSDLRILASR 270
             ....|..|:|  :|..||...:.  .:...|...:: .|....|..|..|:.|..:|:::|...
pombe   204 -LENKGLMVQQ--KLAEELGLLQP--EIAWHTERDRI-AEAGCFLGMLTGTLAKFATDIKLLMQT 262

  Fly   271 K--ELEEPFESTQIGSSAMPYKRNPMRSERCCALARHLITLFSSAANTHATQWLERTLDDSANRR 333
            :  |:.|||::.:..||.||.||||:    .|.    .||..:|.........|:..::|  :.|
pombe   263 EVAEVFEPFKANRGSSSTMPQKRNPI----SCV----YITASTSFVRQGVAALLDAMVED--HER 317

  Fly   334 LT---------LSEAFLAADAALLTLLNISQGLVVYPKVIERHISQELPFMSTENIIMAMV-KAG 388
            .|         |.:.|:.....|...:.:.:||.|:|..:..::|.....:.:|.::||:. |.|
pombe   318 ATGAWEIEWIVLPDVFVHTVGTLKQTVFLLEGLEVHPSRMNENLSITNGLIVSEAVMMALAPKLG 382

  Fly   389 GDR------QVCHEKIRVLSQE---------AGAQVKQHGKDNDLVVRVRKDPYFSPILEQLDTI 438
            .|.      ::||..|    ||         |..||..:....::...:..:.|.....|.::..
pombe   383 RDEAHDLVYRLCHLSI----QENKPLVELLLAERQVTNYLSKEEVTSLLNPENYLGSTFEMIERA 443

  Fly   439 L 439
            |
pombe   444 L 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdSL	NP_650586.2	PurB	12..458	CDD:223094	105/456 (23%)
AdSL	NP_650586.2	Adenylsuccinate_lyase_2	12..447	CDD:176471	105/456 (23%)
SPBC8E4.05c	NP_596842.1	pCLME	10..446	CDD:176469	105/456 (23%)
SPBC8E4.05c	NP_596842.1	PurB	15..445	CDD:223094	105/456 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0015
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60641
OrthoFinder	1	1.000	-	-		FOG0004771
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100666
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720