DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdSL and adsl-1

DIOPT Version :9

Sequence 1:	NP_650586.2	Gene:	AdSL / 42051	FlyBaseID:	FBgn0038467	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_492049.1	Gene:	adsl-1 / 172466	WormBaseID:	WBGene00011064	Length:	478	Species:	Caenorhabditis elegans

Alignment Length:	485	Identity:	216/485 - (44%)
Similarity:	307/485 - (63%)	Gaps:	11/485 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASNYEGYKSPLSTRYA-SKEMQFLFSDQNKFSTWRRLWVWLAKAESRLGL-EISDAQIAEMELQ 63
            |||. :.::|.|||||. :..:..:.|:.||.:.||:||:|||:||..||| :::...|.||:..
Worm     1 MASE-DKFESVLSTRYCKNSPLVSILSETNKATLWRQLWIWLAEAEKELGLKQVTQDAIDEMKSN 64

  Fly    64 ISNIDFEAAAAEERLTRHDVMAHVHVFAKQCPSAAPVIHLGATSCYVGDNTDLIVLRDALKLLLP 128
            ....|:....:|||..:||||||.|.|.|.||:||.:||||||||:|.||.|||..||::..:|.
Worm    65 RDVFDWPFIRSEERKLKHDVMAHNHAFGKLCPTAAGIIHLGATSCFVQDNADLIAYRDSIDHILK 129

  Fly   129 RVASVIARLSQFAQSYKDQPTLGFTHLQPAQLTTVGKRACLWIQDLIMDERALSRCLEDLRFRGV 193
            |.|:||.||:.|:...|:..|:|.||.|.|.|.|||||..||.|:|:|..::||...:.:||||:
Worm   130 RFATVIDRLAAFSLKNKEVVTVGRTHYQTASLVTVGKRGVLWAQELLMAFQSLSEFRDKMRFRGI 194

  Fly   194 KGTTGTQASFLQLFNGDGEKVKQLDQLVTELAGFKKAYAVTGQTYSRKVDVEIVAALASLGTTIH 258
            ||.||||.|||.||.||..||:.||:|||:.|.|...:.:|||||||:.|.::|.:|:.||....
Worm   195 KGATGTQDSFLTLFAGDESKVEALDELVTKKANFSNRFLITGQTYSRQQDSQLVFSLSLLGAAAK 259

  Fly   259 KMCSDLRILASRKELEEPFESTQIGSSAMPYKRNPMRSERCCALARHLITLFSSAANTHATQWLE 323
            |:|:|:|:|.:..||.||||..||||||||||:|||:|||||||:|.||.....|....|.|.||
Worm   260 KVCTDIRVLQAFGELLEPFEKDQIGSSAMPYKKNPMKSERCCALSRKLINAPQEALTILADQGLE 324

  Fly   324 RTLDDSANRRLTLSEAFLAADAALLTLLNISQGLVVYPKVIERHISQELPFMSTENIIMAMVKAG 388
            |||||||.||:.:.:..|.|:|.|.||.||.:||.|....:::.:..|:.|:..|..:|.:.:.|
Worm   325 RTLDDSAGRRMLIPDVLLTAEALLTTLQNIFEGLSVQTDNVKKIVEDEIAFLGLEKAMMMLTEEG 389

  Fly   389 GDRQVCHEKIRVLSQEAGAQVKQHGKDNDLVVR-VRKDPYFSPILEQLDTILDAK-TFTGRASDQ 451
            .|||..|..||..:.||    ||......:.:| ...||:|..:.:::..:::.. .||||...|
Worm   390 VDRQQAHAVIRKTALEA----KQLQATQKVDIRQTMADPFFDSVRDRVVGLVNNPINFTGRCVSQ 450

  Fly   452 VGEFVKEEVEPVLARYSEALKNVQDVKLNI 481
            ...|:.:|::|.:.:|.:  |:..:|:|::
Worm   451 TESFIAKELKPTIDKYLD--KSAGNVQLDV 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdSL	NP_650586.2	PurB	12..458	CDD:223094	206/449 (46%)
AdSL	NP_650586.2	Adenylsuccinate_lyase_2	12..447	CDD:176471	202/438 (46%)
adsl-1	NP_492049.1	purB	11..454	CDD:273345	205/446 (46%)
adsl-1	NP_492049.1	Adenylsuccinate_lyase_2	11..446	CDD:176471	202/438 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167428
Domainoid	1	1.000	230	1.000	Domainoid score	I1394
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1144
Isobase	1	0.950	-	0	Normalized mean entropy	S248
OMA	1	1.010	-	-		QHG60641
OrthoDB	1	1.010	-	-		D268338at33208
OrthoFinder	1	1.000	-	-		FOG0004771
OrthoInspector	1	1.000	-	-		oto20660
orthoMCL	1	0.900	-	-		OOG6_100666
Panther	1	1.100	-	-	LDO	PTHR43172
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2248
SonicParanoid	1	1.000	-	-		X3924
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890