DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdSL and ADSL

DIOPT Version :9

Sequence 1:	NP_650586.2	Gene:	AdSL / 42051	FlyBaseID:	FBgn0038467	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	XP_011528279.1	Gene:	ADSL / 158	HGNCID:	291	Length:	526	Species:	Homo sapiens

Alignment Length:	467	Identity:	317/467 - (67%)
Similarity:	378/467 - (80%)	Gaps:	0/467 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EGYKSPLSTRYASKEMQFLFSDQNKFSTWRRLWVWLAKAESRLGLEISDAQIAEMELQISNIDFE 70
            :.|:|||::||||.||.|:|||:.||.|||:||:|||:||..|||.|:|.||.||:..:.||||:
Human    11 DSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENIDFK 75

  Fly    71 AAAAEERLTRHDVMAHVHVFAKQCPSAAPVIHLGATSCYVGDNTDLIVLRDALKLLLPRVASVIA 135
            .||.||:..|||||||||.|...||.||.:|||||||||||||||||:||:||.||||::|.||:
Human    76 MAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVIS 140

  Fly   136 RLSQFAQSYKDQPTLGFTHLQPAQLTTVGKRACLWIQDLIMDERALSRCLEDLRFRGVKGTTGTQ 200
            ||:.||:.....|||||||.|||||||||||.|||||||.||.:.|.|..:||||||||||||||
Human   141 RLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQ 205

  Fly   201 ASFLQLFNGDGEKVKQLDQLVTELAGFKKAYAVTGQTYSRKVDVEIVAALASLGTTIHKMCSDLR 265
            |||||||.||..||:|||::|||.||||:|:.:|||||:||||:|:::.|||||.::||:|:|:|
Human   206 ASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIR 270

  Fly   266 ILASRKELEEPFESTQIGSSAMPYKRNPMRSERCCALARHLITLFSSAANTHATQWLERTLDDSA 330
            :||:.||:|||||..||||||||||||||||||||:|||||:||......|.:.||.||||||||
Human   271 LLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSA 335

  Fly   331 NRRLTLSEAFLAADAALLTLLNISQGLVVYPKVIERHISQELPFMSTENIIMAMVKAGGDRQVCH 395
            |||:.|:||||.||..|.||.|||:|||||||||||.|.||||||:|||||||||||||.||.||
Human   336 NRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCH 400

  Fly   396 EKIRVLSQEAGAQVKQHGKDNDLVVRVRKDPYFSPILEQLDTILDAKTFTGRASDQVGEFVKEEV 460
            ||||||||:|.:.|||.|.||||:.|::.|.|||||..|||.:||..:||||||.||..|::|||
Human   401 EKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEV 465

  Fly   461 EPVLARYSEALK 472
            .|:|..|...:|
Human   466 YPLLKPYESVMK 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdSL	NP_650586.2	PurB	12..458	CDD:223094	307/445 (69%)
AdSL	NP_650586.2	Adenylsuccinate_lyase_2	12..447	CDD:176471	300/434 (69%)
ADSL	XP_011528279.1	purB	17..460	CDD:273345	306/442 (69%)
ADSL	XP_011528279.1	Adenylsuccinate_lyase_2	17..452	CDD:176471	300/434 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159911
Domainoid	1	1.000	314	1.000	Domainoid score	I1292
eggNOG	1	0.900	-	-		E1_COG0015
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12
Inparanoid	1	1.050	645	1.000	Inparanoid score	I806
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60641
OrthoDB	1	1.010	-	-		D268338at33208
OrthoFinder	1	1.000	-	-		FOG0004771
OrthoInspector	1	1.000	-	-		oto89871
orthoMCL	1	0.900	-	-		OOG6_100666
Panther	1	1.100	-	-	LDO	PTHR43172
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2248
SonicParanoid	1	1.000	-	-		X3924
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840