Protein Alignment CG8907 and Eps8l2

DIOPT Version :10

• Sequence 1: NP_001247146.1
• Gene: CG8907 / 42050
• FlyBaseID: FBgn0038466
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_573454.2
• Gene: Eps8l2 / 98845
• MGIID: 2138828
• Length: 729
• Species: Mus musculus
• Alignment Length: 772
• Identity: 206/772 - (26%)
• Similarity: 323/772 - (41%)
• Gaps: 184/772 - (23%)

  Fly    47 YALEHLATFKLKNEAEVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLD-SDMKEIENFP 110
            |.::|||||.:.....:....:.::.||:|.....:|..::.:..|.:.|.:|| ...:|:||||
Mouse    52 YHVQHLATFIMDKSEAIASVDDAIRKLVQLSSKEKVWAQEVLLQVNDKSLRLLDVESQEELENFP 116

  Fly   111 GSLITEPTAFISDHPQESFN-----NILIFSVPGISLGNTEMHIFQVADVSSVLLVEDLKTL--- 167
                 .||.   .|.|...|     ::|:...........::|.|...:|.:.|:.||:::.
Mouse   117 -----LPTV---QHSQTVLNQLRYPSVLLLVCQDSDQNKPDIHFFHCDEVEAELVQEDIESALAD 173

  Fly   168 ----SKGTPVTVDRNKTPI-----LLPKPERP-----QNQ-----QAKDQYGIAAAV-------- 205
                .|..|.|:..::..|     :||.|:.|     |.|     |||::.|:...|
Mouse   174 YRLGKKMRPQTLKGHQEKIRQRQSILPPPQSPAPIPFQRQPGDSPQAKNRVGLPLPVPFSEPGYR 238

  Fly   206 --AGIAAEKNAIDKEQTERDVQVINHCFEDIERFMARLHYAAEALNELKLRK--EQHNPHG--EG 264
              .....|..|:..::.|::.|::|...:|||.|:|||..||||..:|..||  ::.|..|  ||
Mouse   239 RRESQDEEPRAVLAQRIEKETQILNCTLDDIEWFVARLQKAAEAFKQLNQRKKGKKKNKKGPAEG 303

  Fly   265 LLVLRSRPPIESEFHDILAKAKLALIYSVRLQNQFTKP--ADPVHNVFISLKSIVTVCNDIYVDA 327
            :|.||:|||.|.||.|...|.|||:....:||.....|  |:.||.:|..|..|:..|.    ..
Mouse   304 VLTLRARPPSEGEFVDCFQKTKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIINTCG----SP 364

  Fly   328 GLPQAVLNPLLRRETIAFLNGTLDSNEMQLWQSLGPNWTVPKDQF--KDHKSSYHPIFYDDWSPD 390
            .:.::|.:|||..:.::||.|.|...||.||:|||..|..|:.::  :.....|.|.|...|.|.
Mouse   365 DIARSVSSPLLSTDAVSFLRGHLVPKEMTLWESLGETWMRPRSEWPREPQVPLYVPKFRSGWEPP 429

  Fly   391 WVVDEEVPY----LAPALKKSTTP-------------------SPVPVPMPPSPGLGNRTWLSRL 432
            ..|.:|.|:    ||.......||                   :|..:..|.|....||.:  :.
Mouse   430 LDVLQEAPWEVEGLASVPSDQLTPKNRLSVRHSPKHSLSSESQAPEDIAPPGSSPHANRGY--QP 492

  Fly   433 ESRNVKIAEVTFNKSATNDKELKVTKGEYLEIIDDSRNWWKARNSYGNIGYVPHTVLTPYNFEPG 497
            .....|..::.::.:|.|..||.|.|.|.||:::|.|.|||.||..|..||||..:|
Mouse   493 TPAMTKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRNRSGQAGYVPCNIL-------- 549

  Fly   498 VNGRDTESLASMALTENGGEEAIPPPLYRNTMAMYTAPVEQ-------PAANGKAMQRTFSMPNV 555
                      :.|..|:.|                 ||:||       ||:           |..
Mouse   550 ----------AEARQEDVG-----------------APLEQSGQKYWGPAS-----------PTH 576

  Fly   556 PVPPPMPPPSDSQTPTPSGTLKRNMAAAGALAAMRARNDCEADDQLYYMQGDVHDELRL----LQ 616
            .:||                             :.|.|    .::|.:...:|:|||..    ::
Mouse   577 KLPP-----------------------------IFAGN----KEELIHHMDEVNDELMKKISHIK 608

  Fly   617 QQRERRKDLEILKTPEIFITQNSKPSEVEEWLRGKGFSDIIIKRLHTLSGEEIFALSPHTIESYF 681
            .|.:|...:|..:...:.:|..|.|.||..||..|.||..|::.|..|:|.::|:|:...::...
Mouse   609 TQPQRNFRVERSQPVHLPLTFESGPDEVRAWLEAKAFSARIVENLGILTGPQLFSLNKEELKKVC 673

  Fly   682 GRRESRRLISQIVLQKNFCEYKTIRSSELSAKLARARQKAD---------QSNGNPN 729
            | .|..|:.||:.:||.|.| |....|||...:::.|:..|         :|.|.|:
Mouse   674 G-EEGSRVYSQLTVQKAFLE-KQQSGSELEKLMSKIRRAEDSYTSQHTSPESEGAPH 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921	33/140 (24%)
		SH3_Eps8	439..492	CDD:212698	22/52 (42%)
		SAM_3	630..693	CDD:436214	20/62 (32%)
Eps8l2	NP_573454.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		PTB_EPS8	48..178	CDD:269921	31/133 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..247		14/64 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..492		7/44 (16%)
		SH3_Eps8	499..549	CDD:212698	21/49 (43%)
		SAM_EPS8-like	626..691	CDD:188939	23/65 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	695..729		8/34 (24%)