DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8907 and eps8l2

DIOPT Version :9

Sequence 1:	NP_001247146.1	Gene:	CG8907 / 42050	FlyBaseID:	FBgn0038466	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_002666818.2	Gene:	eps8l2 / 798252	ZFINID:	ZDB-GENE-131121-340	Length:	670	Species:	Danio rerio

Alignment Length:	736	Identity:	187/736 - (25%)
Similarity:	303/736 - (41%)	Gaps:	178/736 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 YALEHLATFKL-KNE--AEVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLDSDMK-EIE 107
            |.::||:||.: |.|  |.|....:|:|||...:|   ||..:|.:....:.:.:||.:.| |:|
Zfish    46 YHVQHLSTFVMDKTEAIATVDDAIKKLKLLDSKDK---IWTQEMLLQVTDKSIKLLDCETKEELE 107

  Fly   108 NFPGSLITEPTAFISDHPQESFNNILIFSVPGISLGNTEMHIFQVADVSSVLLVEDLKTL----- 167
            |||.:.:......::   |..:.::|:...........::|.|...:|.:.::..|:.:.
Zfish   108 NFPLATVHHCQTLLN---QTRYPSVLLLVCQDNEQHKPDIHFFYCDEVEAEMVHADIDSALGDNA 169

  Fly   168 --SKGTPVTVDRNKTPI------LLPKPERPQNQQAKDQYGIAAAVAGI---------AAEKNAI 215
              .|..|.|:..|:..:      ::| |..|....     |:...||..         ..|.|..
Zfish   170 RGKKMRPQTLKLNQEKMKHQRESIIP-PSEPSPGP-----GVKGRVAATDMKDELSMQDPESNMK 228

  Fly   216 DKEQTERDVQVINHCFEDIERFMARLHYAAEALNELKLR----KEQHNPHGEGLLVLRSRPPIES 276
            ..::.|:|||::|...:|||.|:||||.||||..:|..|    |.:.....||:|.||::||.|.
Zfish   229 LAQRIEKDVQILNCSLDDIEIFVARLHKAAEAFAQLNQRNRSKKNKKRGPAEGMLTLRAKPPSEV 293

  Fly   277 EFHDILAKAKLALIYSVRLQNQFTKP--ADPVHNVFISLKSIVTVCNDIYVDAGLPQAVLNPLLR 339
            ||.|.|.|.||:.....:|:.....|  ::.:|.:|..|:.|:....    ...||:||::|.|.
Zfish   294 EFVDCLQKLKLSFNLLAKLKKHIQNPNASELIHFLFGPLELILQSSG----SPDLPRAVISPHLS 354

  Fly   340 RETIAFLNGTLDSNEMQLWQSLGPNWTVPK-DQFKDHKSS-YHPIFYDDWSPDWVVDEEVPY--- 399
            |:.:.||.|.|...||.:::.||..||.|: |..||..:. |.|.|.:.|.|...:....|:
Zfish   355 RDAVDFLRGHLTPKEMTIFELLGDGWTRPRADWPKDQCAPLYVPKFRNGWEPPVELFRTSPWETE 419

  Fly   400 ----------------------LAPALKKSTTPSPVPVPMPPSPGLGNRTWLSRLESRNVKIAEV 442
                                  .:|:...|..|||.|                      .|.|::
Zfish   420 SIGMPKSPVQSEYRSKEFFGSQSSPSSNGSYPPSPAP----------------------RKYAKI 462

  Fly   443 TFNKSATNDKELKVTKGEYLEIIDDSRNWWKARNSYGNIGYVPHTVLTPYNFEPGVNGRDTESLA 507
            .::..|.|..||.|.:.|.||:::|.:.|||.||..|..||||:.:|.....|.
Zfish   463 RYHFVARNANELSVLQDEILEVLEDGKQWWKLRNRSGQAGYVPYNILDVIKLED----------- 516

  Fly   508 SMALTENGGEEAIPPPLYRNTMAMYTAPVEQPAANGKAMQRTFSMPNVPVPPPMPPPSDSQTPTP 572
                                                         |...:.||..|....|:|:.
Zfish   517 ---------------------------------------------PQAMIDPPYSPSYRGQSPSG 536

  Fly   573 SGTLKRNMAAAGALAAMRARNDCEADDQLYYMQGDVHDELRLL---QQQRERRKDLEILKTPEIF 634
            |                   ...:.|..|..|. .|:|||.:|   .:..:..::.::::.....
Zfish   537 S-------------------QGSDKDSHLQQMD-KVNDELLMLITSNKIHQPTRNFKVVRQSAGP 581

  Fly   635 ITQNSKPSEVEEWLRGKGFSDIIIKRLHTLSGEEIFALSPHTIESYFGRRESRRLISQIVLQKNF 699
            :|..|.|:||..||..||||...::||..|:|.::|:|:...:::..| .|..|:.|||.:||:.
Zfish   582 LTFESSPAEVTSWLNAKGFSKPTVERLGILTGAQLFSLNKDHLKAVCG-DEGSRVYSQITVQKSQ 645

  Fly   700 CEYKTIRSSELSAKLARARQK 720
            .| |:...|||...:.|.::|
Zfish   646 LE-KSRGVSELEEIMIRQQEK 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921	33/138 (24%)
		SH3_Eps8	439..492	CDD:212698	21/52 (40%)
		SAM_superfamily	635..699	CDD:301707	25/63 (40%)
eps8l2	XP_002666818.2	PTB_EPS8	42..172	CDD:269921	31/131 (24%)
		SH3_Eps8	459..510	CDD:212698	20/50 (40%)
		SAM_EPS8-like	581..646	CDD:188939	25/65 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5861
eggNOG	1	0.900	-	-		E1_KOG3557
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	283	1.000	Inparanoid score	I2853
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	1	1.000	-	-		FOG0001461
OrthoInspector	1	1.000	-	-		otm26368
orthoMCL	1	0.900	-	-		OOG6_106655
Panther	1	1.100	-	-	O	PTHR12287
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4036
SonicParanoid	1	1.000	-	-		X1022
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.860